骨硬化性

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/15 13:29:25」(JST)

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Osteosclerosis is an elevation in bone density.^[1] It can be a pathology, normally detected on a radiograph as an area of increased opacity; that is, where more mineral is present in the bone to absorb or deflect the X-ray beam. Localized osteosclerosis can be caused by injuries that compress the bone, by osteoarthritis, and osteoma.

It is associated with:

Melorheostosis
Osteopetrosis
Osteopoikilosis
Chronic idiopathic myelofibrosis
Skeletal fluorosis

It can also be associated with Hepatitis C.^[2]

In the animal kingdom there also exists a non-pathological form of osteosclerosis, resulting in unusually solid bone structure with little to no marrow. It is often seen in in aquatic vertebrates, especially those living in shallow waters,^[3] providing ballast as an adaptation for an aquatic existence. It makes bones more heavy, but also more fragile. In those animal groups osteosclerosis often occurs together with bone thickening (pachyostosis). This joint occurrence is called pachyosteosclerosis.

References

^ "Medcyclopaedia - Osteosclerosis". Archived from the original on 2012-02-05. Retrieved 2007-12-23.
^ Fiore CE, Riccobene S, Mangiafico R, Santoro F, Pennisi P (2005). "Hepatitis C-associated osteosclerosis (HCAO): report of a new case with involvement of the OPG/RANKL system". Osteoporos Int 16 (12): 2180–4. doi:10.1007/s00198-005-1858-8. PMID 15983730.
^ Houssaye, A. (2009). "Pachyostosis" in aquatic amniotes: a review. Integrative Zoology 4(4): 325-340.

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English Journal

Osteosclerotic bone dysplasia in siblings with a Fam20C mutation.

Fradin M, Stoetzel C, Muller J, Koob M, Christmann D, Debry C, Kohler M, Isnard M, Astruc D, Desprez P, Zorres C, Flori E, Dollfus H, Doray B.SourceService de Genetique Medicale, CHU Strasbourg, Hopital de Hautepierre, Avenue Moliere, Strasbourg, France Laboratoire de Genetique Medicale EA3949, Equipe AVENIR-Inserm, Faculte de Medecine, Universite de Strasbourg, Strasbourg, France Laboratoire de Diagnostic Genetique, CHU Strasbourg, Nouvel Hopital Civil, Strasbourg, France Institut de Genetique et de Biologie Moleculaire et Cellulaire (IGBMC), CNRS, INSERM, Universite de Strasbourg, Illkirch-Graffenstaden, France Service de Radiologie 2, CHU Strasbourg, Hopital de Hautepierre, Strasbourg, France Service d'Oto-Rhino-Laryngologie, CHU Strasbourg, Hopital de Hautepierre, Avenue Moliere, Strasbourg, France Departement d'Echographie et de Medecine F?tale, CMCO-SIHCUS, Schiltigheim, France Service de Gynecologie Obstetrique, Hopital de Belfort-Montbeliard, Belfort, France Service de Reanimation Pediatrique Specialisee-Surveillance Continue, Pediatrie 2, CHU Strasbourg, Hopital de Hautepierre, Avenue Moliere, Strasbourg, France Service de Cytogenetique, CHU Strasbourg, Hopital de Hautepierre, Avenue Moliere, Strasbourg, France.
Clinical genetics.Clin Genet.2011 Aug;80(2):177-183. doi: 10.1111/j.1399-0004.2010.01516.x. Epub 2010 Jul 23.
Fradin M, Stoetzel C, Muller J, Koob M, Christmann D, Debry C, Kohler M, Isnard M, Astruc D, Desprez P, Zorres C, Flori E, Dollfus H, Doray B. Osteosclerotic bone dysplasia in siblings with a Fam20C mutation. Raine syndrome is an autosomal recessive disorder caused by mutations in the FAM20C gene. F
PMID 20825432

Early gastric cancer combined with multiple metachronous osteosclerotic bone and bone marrow metastases that responded to chemoradiotherapy.

Saito M, Kiyozaki H, Chiba F, Takata O, Yoshida T, Shuto C, Yamada S, Konishi F.SourceDepartment of Surgery, Jichi Medical University Saitama Medical Center, Amanuma-cho 1-847, Omiya-ku, Saitama, Japan, msaito@jichi.ac.jp.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association.Gastric Cancer.2011 Aug;14(3):295-9. Epub 2011 Jun 14.
We report a 75-year-old woman who suffered multiple metachronous osteosclerotic bone metastases 4?years after a distal gastrectomy for early gastric cancer (EGC). The primary tumor was a poorly differentiated adenocarcinoma, which had invaded the submucosal layer, and only one lymph node metastasis
PMID 21671047

Japanese Journal

症例多発性の硬化性骨転移を来した小脳髄芽腫の1例

松山直弘,岩野文彦,浦崎永一郎 [他]
臨床放射線 56(5), 653-656, 2011-05
NAID 40018839750

変形性肩鎖関節症における画像評価

間中智哉,伊藤陽一,松本一伸,大戎直人,中村信之,中村博亮
肩関節 34(2), 503-506, 2010
… X-ray images were assessed by the following 3 items: joint space narrowing, osteophyte formation and osteosclerotic change. … X-ray images evaluation revealed joint space narrowing in 27 shoulders (67.5%), osteophyte formation in 28 shoulders (70%) and osteosclerotic change in 20 shoulders (50%). …
NAID 130000339502