osteopetrotic

WordNet

an inherited disorder characterized by an increase in bone density; in severe forms the bone marrow cavity may be obliterated (同)Albers-Schonberg_disease, marble bones disease

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1. 骨格の正常な発達および骨形成ならびに骨吸収の調節 normal skeletal development and regulation of bone formation and resorption

Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo.

Frara N1, Abdelmagid SM2, Sondag GR3,4, Moussa FM3,4, Yingling VR5, Owen TA6, Popoff SN1, Barbe MF1, Safadi FF3,4.
Journal of cellular physiology.J Cell Physiol.2016 Jan;231(1):72-83. doi: 10.1002/jcp.25020.
Initial identification of osteoactivin (OA)/glycoprotein non-melanoma clone B (gpnmb) was demonstrated in an osteopetrotic rat model, where OA expression was increased threefold in mutant bones, compared to normal. OA mRNA and protein expression increase during active bone regeneration post-fracture
PMID 25899717

Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass.

Decker CE1, Yang Z2, Rimer R3, Park-Min KH4, Macaubas C5, Mellins ED5, Novack DV3, Faccio R6.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2015 Dec 22;112(51):15654-9. doi: 10.1073/pnas.1511285112. Epub 2015 Dec 7.
Phospholipase C gamma-2 (PLCγ2)-dependent calcium (Ca(2+)) oscillations are indispensable for nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1) activation and downstream gene transcription driving osteoclastogenesis during skeletal remodeling and pathological bone loss. Here we describe,
PMID 26644563

Nango N1, Kubota S2, Hasegawa T3, Yashiro W4, Momose A5, Matsuo K6.
Bone.Bone.2015 Dec 17. pii: S8756-3282(15)00428-7. doi: 10.1016/j.bone.2015.12.006. [Epub ahead of print]
The mammalian skeleton stores calcium and phosphate ions in bone matrix. Numerous osteocytes in osteocyte lacunae extend a large number of dendrites into canaliculi that are less than a micron in diameter and distributed throughout bone matrix. Although osteoclasts are the primary bone-resorbing cel
PMID 26709236

Sanefuji K.,Zeredo J. L.,Kurose M.,Tanaka M.,Koga Y.,Yamada Y.,Yoshida N.
日本顎口腔機能学会雑誌 14(2), 89-95, 2008-02-28
… For this purpose, we recorded the jaw movement trajectory in the three dimensions and electromyographic (EMG) activity of MAS and DIG muscles in freely behaving osteopetrotic (op/op) and normal mice. …
NAID 110006666072