オルトレオウイルス

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/11/05 21:20:06」(JST)

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Orthoreoviruses are members of the Reoviridae virus family. They have double stranded RNA genomes and are therefore group III viruses. These viruses infect vertebrates (including humans) but no disease symptoms are normally seen. In some cases however, orthoreovirus infection can lead to complications, especially in mice and birds.

The structure of the virus particles is complex. The virus is non-enveloped and has icosahedral symmetry with a triangulation number of 13. It can be compared to a wheel with spokes radiating out of it. The virus has a double protein shell. The outer shell is approximately 80 nm in diameter and the inner shell is 60 nm in diameter.

The genome can be divided into three main classes: L (large), M (medium) and S (small). The L genes encode λ proteins, the M genes encode μ proteins and the S genes encode σ proteins. σ1, σ3, λ2 and μ1c proteins make up in the outer capsid. Proteins λ1, λ3, σ2 and μ2 make up the inner capsid.

Replication of the virus takes place in the host cell cytoplasm.

Like other members of the Reoviridae family, the reoviruses are non-enveloped and characterized by concentric capsid shells that encapsidate a segmented dsRNA genome. A reovirus has eight structural proteins and ten segments of dsRNA. A series of uncoating steps and conformational changes accompany cell entry and replication. High-resolution structures are known for almost all of the proteins of mammalian reovirus (MRV), which is the best-studied genotype. Electron cryo-microscopy (cryoEM) and X-ray crystallography have provided a wealth of structural information about two specific MRV strains, type 1 Lang (T1L) and type 3 Dearing (T3D).^[1]

References

^ Dryden et al. (2008). "The Structure of Orthoreoviruses". Segmented Double-stranded RNA Viruses: Structure and Molecular Biology. Caister Academic Press. ISBN 978-1-904455-21-9.

External links

MicrobiologyBytes - Reoviruses
Viralzone: Orthoreovirus

English Journal

The E3 ubiquitin ligase TRIM21 negatively regulates the innate immune response to intracellular double-stranded DNA.

Zhang Z, Bao M, Lu N, Weng L, Yuan B, Liu YJ.SourceBaylor Institute for Immunology Research, Baylor Research Institute, Dallas, Texas, USA.
Nature immunology.Nat Immunol.2013 Feb;14(2):172-8. doi: 10.1038/ni.2492. Epub 2012 Dec 9.
DDX41 is a sensor of intracellular double-stranded DNA (dsDNA) in myeloid dendritic cells (mDCs) that triggers a type I interferon response via the signaling adaptor STING. We identified the E3 ligase TRIM21 as a DDX41-interacting protein and found that knockdown of or deficiency in TRIM21 resulted
PMID 23222971

Identification of Mammalian orthoreovirus type 3 in Italian bats.

Lelli D, Moreno A, Lavazza A, Bresaola M, Canelli E, Boniotti MB, Cordioli P.SourceIstituto Zooprofilattico Sperimentale della Lombardia e dell'Emilia Romagna, IZSLER, Brescia, Italy. davide.lelli@izsler.it
Zoonoses and public health.Zoonoses Public Health.2013 Feb;60(1):84-92. doi: 10.1111/zph.12001. Epub 2012 Aug 30.
Summary This study describes the isolation and molecular characterization of Mammalian orthoreovirus (MRV) in microbats. Faecal samples and dead individuals available from rehabilitation centres or collected from known roost sites were virologically tested. In total, 112 carcasses of bats found dead
PMID 22931153

Piscine Reovirus Encodes a Cytotoxic, Nonfusogenic, Integral Membrane Protein and Previously Unrecognized Virion Outer-Capsid Proteins.

Key T, Read J, Nibert ML, Duncan R.SourceDalhousie University;
The Journal of general virology.J Gen Virol.2013 Jan 23. [Epub ahead of print]
Piscine reovirus (PRV) is a new member of the family Reoviridae and has been linked to heart and skeletal muscle inflammation in farmed Atlantic salmon (Salmo salar L.). Recent sequence-based evidence suggests PRV is about equally related to both genus Orthoreovirus and genus Aquareovirus. Sequence
PMID 23343626

Japanese Journal

オルソレオウイルス

ウイルス 64(2), 191-202, 2014
NAID 130005103365

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拡張検索	「mammalian orthoreovirus 3」「mammalian orthoreovirus」

「mammalian orthoreovirus 3」

Orthoreovirus
Virus classification
Group:	Group III (dsRNA)
Order:	Unassigned
Family:	Reoviridae
Subfamily:	Spinareovirinae
Genus:	Orthoreovirus
Type species
	Mammalian orthoreovirus;
Species
	Avian orthoreovirus; Baboon orthoreovirus; Kampar virus; Mammalian orthoreovirus; Melaka virus; Nelson Bay virus; Pulau virus; Reptilian orthoreovirus; Steller sea lion reovirus Tvärminne avian virus; Xi River virus