oncocytoma

オンコサイトーマ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/06/09 11:19:43」(JST)

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Oncocytoma
Classification and external resources
Micrograph of a parotid gland oncocytoma (right of image). Normal parotid gland is also present (left of image). H&E stain.
ICD-O:	M8290/0
DiseasesDB	31956
MeSH	D018249

Gross appearance of the cut surface of a nephrectomy specimen containing a renal oncocytoma. Note the rounded contour, the mahogany colour and the central scar.

An oncocytoma is a tumor made up of oncocytes, epithelial cells characterized by an excessive amount of mitochondria, resulting in an abundant acidophilic, granular cytoplasm. The cells and the tumor that they compose are often benign but sometimes may be premalignant or malignant.

Presentation

An oncocytoma is an epithelial tumor composed of oncocytes, large eosinophilic cells having small, round, benign-appearing nuclei with no nucleoli.

Oncocytoma can arise in a number of organs.

Renal oncocytoma

Main article: renal oncocytoma

Salivary gland oncocytoma

Oncocytoma of the Salivary Gland. This lesion presented as a lateral anterior neck mass. At surgery, it was found to be a soft 3.0 x 2.1 x 1.8 cm tumor of the submandibular salivary gland. The photo shows the characteristic dark color of an oncocytoma, a rare type of benign neoplasm, at the left side of the image (the normal lobulated salivary gland tissue is to the right).

The salivary gland oncocytoma is a well-circumscribed, benign neoplastic growth also called an oxyphilic adenoma. It comprises about 1% of all salivary gland tumors. The histopathology is marked by sheets of large swollen polyhedral epithelial oncocytes, which are granular acidophilic parotid cells with centrally located nuclei. The granules are created by the mitochondria.

Symptoms

Salivary gland oncocytomas are most common in ages 70–80, females, the parotid gland (85-90%), and are firm, slowly growing, painless masses of < 4 cm. They may be bilateral.

Thyroid oncocytoma

Thyroid oncocytomas can be benign (adenomas) or malignant (carcinomas). Grossly, oncocytic adenomas are encapsulated, solid nodules with a characteristic brown cut surface. The gross appearance of a minimally invasive oncocytic carcinoma is indistinguishable to that of an adenoma, while widely invasive oncocytic carcinomas are obviously invasive macroscopically and display pervasive vascular invasion with multifocal involvement of the thyroid gland. There are no reliable cytologic features which distinguish oncocytic adenomas from carcinomas and the only criteria for a diagnosis of malignancy is the identification of transcapsular and/or vascular invasion.

Symptoms

Patients with thyroid oncocytomas present with a thyroid nodule, usually with normal thyroid function. If the tumor is big or invasive, there may be other symptoms such as difficulty swallowing or talking.

See also

• Kidney
• Renal cell carcinoma
• Hurthle cell

Additional images

• Micrograph of a renal oncocytoma. H&E stain.

• Micrograph of a renal oncocytoma. H&E stain.

References

UpToDate Contents

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• 1. 腎細胞癌の疫学、病理、および病因 epidemiology pathology and pathogenesis of renal cell carcinoma
• 2. 腎の小腫瘤の診断的アプローチ、鑑別診断、および治療 diagnostic approach differential diagnosis and treatment of a small renal mass
• 3. 腎血管筋脂肪腫 renal angiomyolipomas
• 4. 慢性苔癬状粃糠疹 pityriasis lichenoides chronica
• 5. 結節性硬化症の腎症状 renal manifestations of tuberous sclerosis complex

English Journal

• Laparoscopic Partial Nephrectomy.

• Caceres F, Nunez-Mora C, Cabrera PM, Garcia-Mediero JM, Garcia-Tello A, Angulo JC.SourceServicio de Urologia, Hospital Universitario de Getafe, Madrid, Espana.
• Actas urologicas espanolas.Actas Urol Esp.2011 Sep;35(8):487-493.
• OBJETIVES: To analyze the surgical and oncologic outcome of prospective experience with laparoscopic partial nephrectomy. We describe the surgical technique and mid term oncological results achieved.MATERIAL AND METHODS: 60 patients were operated with this technique between June 2005 and June 2009.
• PMID 21641090

• Cathepsin K expression in the spectrum of perivascular epithelioid cell (PEC) lesions of the kidney.

• Martignoni G, Bonetti F, Chilosi M, Brunelli M, Segala D, Amin MB, Argani P, Eble JN, Gobbo S, Pea M.SourceDepartment of Pathology and Diagnostics, University of Verona, Verona, Italy.
• Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.Mod Pathol.2011 Aug 26. doi: 10.1038/modpathol.2011.136. [Epub ahead of print]
• The perivascular epithelioid cell (PEC) is a unique cell type coexpressing contractile proteins (mainly α-smooth muscle actin), melanocytic markers, including microphthalmia-associated transcription factor (MITF), and estrogen and progesterone receptors. It is constantly present in a group of tumor
• PMID 21874011

Japanese Journal

• Immunohistochemical application of S100A1 in renal oncocytoma, oncocytic papillary renal cell carcinoma, and two variants of chromophobe renal cell carcinoma

• KURODA Naoto,KANOMATA Naoki,YAMAGUCHI Tadanori,IMAMURA Yoshiaki,OHE Chisato,SAKAIDA Noriko,HES Ondrej,MICHAL Michal,SHUIN Taro,LEE Gang-Hong
• Medical molecular morphology : official journal of the Japanese Society for Clinical Molecular Morphology 44(2), 111-115, 2011-06-01
• NAID 10029036907

• Renal mass sampling : An enlightened perspective

• SAMPLASKI Mary K,ZHOU Ming,LANE Brian R,HERTS Brian,CAMPBELL Steve C
• International journal of urology 18(1), 5-19, 2011-01-01
• NAID 10027901630

• Editorial Comment from Dr Picken to Molecular pathology of renal oncocytoma : A review

• PICKEN Maria M
• International journal of urology 17(7), 613-614, 2010-07-01
• NAID 10027259251

Related Links

• Renal Oncocytoma Imaging: Overview, Radiography ...

Oncocytoma is the most common benign solid renal tumor (see the images below). First described by Zippel in 1942, this tumor represents a distinct pathologic entity. ... Epidemiology In most reviews, oncocytomas ...

• Renal oncocytoma | Radiology Reference Article ...

Renal oncocytoma is a type of relatively benign renal tumour. The main clinical importance of this lesion is the difficulty in pre-operatively distinguishing it from renal cell carcinomas, as epidemiology, presentation, imaging and even ...

Related Pictures

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★リンクテーブル★

リンク元	「オンコサイトーマ」「eosinophilic adenoma」「好酸性顆粒細胞腺腫」「Hurthle cell tumor」「acidophil adenoma」
拡張検索	「renal oncocytoma」

「オンコサイトーマ」

　　[★]

英

oncocytoma

同

膨大細胞腫 膨大細胞腺腫 oncocytic adenoma、好酸性腺腫 oxyphilic adenoma

関

好酸性顆粒細胞腺腫

「eosinophilic adenoma」

　　[★]

好酸性腺腫、エオシン好性腺腫

関

acidophil adenoma、Hurthle cell tumor、oncocytoma、oxyphilic adenoma

「好酸性顆粒細胞腺腫」

　　[★]

英

oncocytoma

関

オンコサイトーマ、好酸性腺腫、膨大細胞腫、甲状腺好酸性細胞腫瘍

「Hurthle cell tumor」

　　[★]

甲状腺好酸性細胞腫瘍

関

acidophil adenoma、eosinophilic adenoma、oncocytoma、oxyphilic adenoma

「acidophil adenoma」

　　[★]

好酸性腺腫

関

eosinophilic adenoma、Hurthle cell tumor、oncocytoma、oxyphilic adenoma

「renal oncocytoma」

　　[★]

腎膨大細胞腫、腎オンコサイトーマ