olvanil

English Journal

Kobata K1, Takemura I, Tago G, Moriya T, Kubota K, Nakatani S, Wada M, Watanabe T.
Bioscience, biotechnology, and biochemistry.Biosci Biotechnol Biochem.2014;78(7):1242-5. doi: 10.1080/09168451.2014.912118. Epub 2014 May 28.
Long-chain N-vanillyl-acylamides (LCNVAs) were generated from plant oils and vanillylamine (VA) by nucleophilic amidation without any catalytic reagents. The resulting LCNVAs varied according to the fatty acid composition of the plant oil used. Therefore, the LCNVAs contained in Capsicum oleoresins
PMID 25229865

Fatty acid amide hydrolase-dependent generation of antinociceptive drug metabolites acting on TRPV1 in the brain.

Barrière DA1, Mallet C, Blomgren A, Simonsen C, Daulhac L, Libert F, Chapuy E, Etienne M, Högestätt ED, Zygmunt PM, Eschalier A.
PloS one.PLoS One.2013 Aug 5;8(8):e70690. doi: 10.1371/journal.pone.0070690. Print 2013.
The discovery that paracetamol is metabolized to the potent TRPV1 activator N-(4-hydroxyphenyl)-5Z,8Z,11Z,14Z-eicosatetraenamide (AM404) and that this metabolite contributes to paracetamol's antinociceptive effect in rodents via activation of TRPV1 in the central nervous system (CNS) has provided a
PMID 23940628

Inhibition by capsaicin and its related vanilloids of compound action potentials in frog sciatic nerves.

Tomohiro D1, Mizuta K, Fujita T, Nishikubo Y, Kumamoto E.
Life sciences.Life Sci.2013 Mar 14;92(6-7):368-78. doi: 10.1016/j.lfs.2013.01.011. Epub 2013 Jan 24.
AIMS: Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1) channels but also inhibits nerve conduction, the latter action has not yet been fully examined. The purpose of the present study was to know whether various vanilloids have an inhibitory action similar to th
PMID 23352977