ヌクレオチダーゼ
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/09/13 21:52:58」(JST)
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A nucleotidase is a hydrolytic enzyme that catalyzes the hydrolysis of a nucleotide into a nucleoside and a phosphate. For example, it converts adenosine monophosphate to adenosine, and guanosine monophosphate to guanosine.
Nucleotidases have an important function in digestion in that they break down consumed nucleic acids.
They can be divided into two categories, based upon the end that is hydrolyzed:
- EC 3.1.3.5: 5'-nucleotidase - NT5C, NT5C1A, NT5C1B, NT5C2, NT5C3
- EC 3.1.3.6: 3'-nucleotidase - NT3
5'-Nucleotidases cleave off the phosphate from the 5' end of the sugar moiety. They can be classified into various kinds depending on their substrate preferences and subcellular localization. Membrane-bound 5'-nucleotidases display specificity toward adenosine monophosphates and are involved predominantly in the salvage of preformed nucleotides and in signal transduction cascades involving purinergic receptors. Soluble 5'-nucleotidases are all known to belong to the haloacid dehalogenase superfamily of enzymes, which are two domain proteins characterised by a modified Rossman fold as the core and variable cap or hood. The soluble forms are further subclassified based on the criterion mentioned above. mdN and cdN are mitochondrial and cytosolic 5'-3'-pyrimidine nucleotidases. cN-I is a cytosolic nucleotidase(cN) characterized by its affinity toward AMP as its substrate. cN-II is identified by its affinity toward either IMP or GMP or both. cN-III is a pyrimidine 5'-nucleotidase. 5'-Nucleotidases are involved in varied functions like cell-cell communication, nucleic acid repair, purine salvage pathway for the synthesis of nucleotides, signal transduction, membrane transport, etc.
References
- Hunsucker, S. A., Mitchell, B. S. and Spychala, J. (2005). "The 5'-nucleotidases as regulators of nucleotide and drug metabolism". Pharmacol. Ther. 107, 1–30.
External links
- Nucleotidases at the US National Library of Medicine Medical Subject Headings (MeSH)
Hydrolase: esterases (EC 3.1)
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3.1.1: Carboxylic
ester hydrolases |
- Cholinesterase
- Acetylcholinesterase
- Butyrylcholinesterase
- Pectinesterase
- 6-phosphogluconolactonase
- PAF acetylhydrolase
- Lipase
- Bile salt-dependent
- Gastric/Lingual
- Pancreatic
- Lysosomal
- Hormone-sensitive
- Endothelial
- Hepatic
- Lipoprotein
- Monoacylglycerol
- Diacylglycerol
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3.1.2: Thioesterase |
- Palmitoyl protein thioesterase
- Ubiquitin carboxy-terminal hydrolase L1
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3.1.3: Phosphatase |
- Alkaline phosphatase
- Acid phosphatase (Prostatic)/Tartrate-resistant acid phosphatase/Purple acid phosphatases
- Nucleotidase
- Glucose 6-phosphatase
- Fructose 1,6-bisphosphatase
- Protein phosphatase
- OCRL
- Pyruvate dehydrogenase phosphatase
- Fructose 6-P,2-kinase:fructose 2,6-bisphosphatase
- PTEN
- Phytase
- Inositol-phosphate phosphatase
- Protein phosphatase: Protein tyrosine phosphatase
- Protein serine/threonine phosphatase
- Dual-specificity phosphatase
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3.1.4: Phosphodiesterase |
- Autotaxin
- Phospholipase
- Sphingomyelin phosphodiesterase
- PDE1
- PDE2
- PDE3
- PDE4A/PDE4B
- PDE5
- Lecithinase (Clostridium perfringens alpha toxin)
- Cyclic nucleotide phosphodiesterase
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3.1.6: Sulfatase |
- arylsulfatase
- Arylsulfatase A
- Arylsulfatase B
- Arylsulfatase E
- Steroid sulfatase
- Galactosamine-6 sulfatase
- Iduronate-2-sulfatase
- N-acetylglucosamine-6-sulfatase
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Nuclease (includes
deoxyribonuclease and
ribonuclease) |
3.1.11-16: Exonuclease |
Exodeoxyribonuclease |
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Exoribonuclease |
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3.1.21-31: Endonuclease |
Endodeoxyribonuclease |
- Deoxyribonuclease I
- Deoxyribonuclease II
- Deoxyribonuclease IV
- Restriction enzyme
- UvrABC endonuclease
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Endoribonuclease |
- RNase III
- RNase H
- RNase P
- RNase A
- RNase T1
- RNA-induced silencing complex
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either deoxy- or ribo- |
- Aspergillus nuclease S1
- Micrococcal nuclease
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- Biochemistry overview
- Enzymes overview
- By EC number: 1.1
- 2
- 3
- 4
- 5
- 6
- 7
- 8
- 10
- 11
- 13
- 14
- 15-18
- 2.1
- 3.1
- 4.1
- 5.1
- 6.1-3
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UpToDate Contents
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English Journal
- Periodontal disease and high doses of inhaled corticosteroids alter NTPDase activity in the blood serum of rats.
- Scarabelot VL1, Cavagni J2, Medeiros LF1, Detânico B1, Rozisky JR1, de Souza A1, Daudt LD2, Gaio EJ2, Ferreira MB3, Rösing CK2, Battastini AM4, Torres IL5.
- Archives of oral biology.Arch Oral Biol.2014 Aug;59(8):841-7. doi: 10.1016/j.archoralbio.2014.05.004. Epub 2014 May 14.
- BACKGROUND: Certain drugs such as glucocorticoids may interfere with the modulation of periodontal disease. In contrast, corticosteroid treatment has been associated with a protective effect with regard to periodontal breakdown, depending on the dose, pathway, and exposure time. Considering the pote
- PMID 24863659
- Involvement of P2Y11 receptor in silica nanoparticles 30-induced IL-6 production by human keratinocytes.
- Nagakura C1, Negishi Y1, Tsukimoto M1, Itou S2, Kondo T2, Takeda K3, Kojima S4.
- Toxicology.Toxicology.2014 Aug 1;322:61-8. doi: 10.1016/j.tox.2014.03.010. Epub 2014 May 2.
- We have previously reported that P2Y11 receptor mediates IFN-γ-induced IL-6 production in human keratinocytes, suggesting the importance of purinergic signaling in skin inflammatory diseases. In this study, the involvement of various P2 receptors in IL-6 production induced by silica nanoparticle 30
- PMID 24793913
- NT5C3 polymorphisms and outcome of first induction chemotherapy in acute myeloid leukemia.
- Cheong HS1, Koh Y, Ahn KS, Lee C, Shin HD, Yoon SS.
- Pharmacogenetics and genomics.Pharmacogenet Genomics.2014 Jul 3. [Epub ahead of print]
- AIMS: The cytosolic 5'-nucleotidase-III (NT5C3) is involved in the metabolism of the nucleoside analog, cytosine arabinose (AraC), and the expression level of NT5C3 is correlated with sensitivity to AraC in acute myeloid leukemia (AML) patients. The current study examined whether the NT5C3 polymorph
- PMID 25000516
Japanese Journal
- Effect of Scutia buxifolia Reissek in nucleotidase activities and inhibition of platelet aggregation
- Boligon Aline Augusti,Pimentel Victor Camera,Bagatini Margarete Dulce [他]
- Journal of natural medicines 69(1), 46-54, 2015
- NAID 40020304954
- Immunosuppression via adenosine receptor activation by adenosine monophosphate released from apoptotic cells.
- Yamaguchi Hiroshi,Maruyama Toshihiko,Urade Yoshihiro,Nagata Shigekazu
- eLife 3, 2014-03-25
- … A nucleotidase inhibitor and A2a adenosine receptor antagonist inhibited the apoptotic supernatant-induced gene expression, suggesting AMP was metabolized to adenosine by an ecto-5'-nucleotidase expressed on macrophages, to activate the macrophage A2a adenosine receptor. …
- NAID 120005439169
- 移植片対宿主病と移植片対腫瘍効果における細胞外アデノシン産生系の機能解析とその薬学的制御に関する研究
Related Links
- nucleotidase nu·cle·o·ti·dase (nōō'klē-ə-tī'dās, -dāz, nyōō'-) n. An enzyme that catalyzes the hydrolysis of a nucleotide to a nucleoside and phosphoric acid.
- ヒト血清・血漿試料中の5'-nucleotidase(5'-NT)活性を,比色法により簡便かつ短時間で測定できるキットです。5'-NTによるイノシン-5'-モノリン酸(5'-IMP)の加水分解反応を,酵素カップリングにより生成するキノン色素の発色で検出します。
Related Pictures
![Bioinformatyka 5'-nucleotidase; EC 3.1.3.5](https://1mg.info/0/1/v/0483.jpg)
![Pyrimidine 5-Nucleotidase Superactivity](https://1mg.info/0/1/v/0484.jpg)
![Mouse 5'‑Nucleotidase/CD73 Antibody](https://1mg.info/0/1/v/0485.jpg)
![Extracellular 5′- nucleotidase](https://1mg.info/0/1/v/0486.jpg)
![cytosolic 5'- nucleotidase](https://1mg.info/0/1/v/0487.jpg)
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