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Influence of particle size and reactive oxygen species on cobalt chrome nanoparticle-mediated genotoxicity.

Raghunathan VK, Devey M, Hawkins S, Hails L, Davis SA, Mann S, Chang IT, Ingham E, Malhas A, Vaux DJ, Lane JD, Case CP.SourceBristol Implant Research Centre, Avon Orthopaedic Centre, Southmead Hospital, Bristol BS10 5NB, UK. Electronic address: vraghunathan@ucdavis.edu.
Biomaterials.Biomaterials.2013 May;34(14):3559-70. doi: 10.1016/j.biomaterials.2013.01.085. Epub 2013 Feb 20.
Patients with cobalt chrome (CoCr) metal-on-metal (MOM) implants may be exposed to a wide size range of metallic nanoparticles as a result of wear. In this study we have characterised the biological responses of human fibroblasts to two types of synthetically derived CoCr particles [(a) from a tribo
PMID 23433773

Oct-1 recruitment to the nuclear envelope in adult-onset autosomal dominant leukodystrophy.

Columbaro M, Mattioli E, Maraldi NM, Ortolani M, Gasparini L, D'Apice MR, Postorivo D, Nardone AM, Avnet S, Cortelli P, Liguori R, Lattanzi G.SourceRizzoli Orthopaedic Institute, Laboratory of Musculoskeletal Cell Biology, RAMSES, and Laboratory for Orthopaedic Pathophysiology and Regenerative Medicine, Bologna, Italy.
Biochimica et biophysica acta.Biochim Biophys Acta.2013 Mar;1832(3):411-20. doi: 10.1016/j.bbadis.2012.12.006. Epub 2012 Dec 20.
Adult-onset autosomal dominant leukodystrophy (ADLD) is a slowly progressive neurological disorder characterised by pyramidal, cerebellar, and autonomic disturbances. Duplication of the LMNB1 gene is the genetic cause of ADLD, yet the pathogenetic mechanism is not defined. In this study, we analysed
PMID 23261988

Assessment of exposure to organochlorine pesticides and levels of DNA damage in mother-infant pairs of an agrarian community.

Alvarado-Hernandez DL, Montero-Montoya R, Serrano-García L, Arellano-Aguilar O, Jasso-Pineda Y, Yáñez-Estrada L.SourceDepartamento de Toxicología Ambiental, Facultad de Medicina, Laboratorio de Género, Salud y Ambiente, Universidad Autónoma de San Luis Potosí, San Luis Potosí, S.L.P., México.
Environmental and molecular mutagenesis.Environ Mol Mutagen.2013 Mar;54(2):99-111. doi: 10.1002/em.21753. Epub 2013 Jan 28.
Exposure to organochlorine pesticides was studied in a group of mother-infant pairs living in a rural area where agriculture is the main economic activity. Fumigation in this zone is performed with airplanes, thus affecting the inhabited areas around them, including schools. Heparinized venous blood
PMID 23355095

Drosophila GTPase Nucleostemin 2 Changes Cellular Distribution during Larval Development and the GTP-Binding Motif Is Essential to Nucleoplasmic Localization

Matsuo Eriko,Nagamine Toshihiro,Matsumoto Shogo [他],TSUNEIZUMI Kazuhide
Bioscience, biotechnology, and biochemistry 75(8), 1511-1515, 2011-08-23
Nucleostemin (NS), a nucleolar guanosine triphosphate (GTP)-binding protein, plays significant roles in cell cycle progression and ribosomal biogenesis. <I>Drosophila</I> Nucleostemin 2 (N …
NAID 10029591473

Dedifferentiation of Human Terminally Differentiating Keratinocytes into Their Precursor Cells Induced by Basic Fibroblast Growth Factor

Sun Xiaoyan,Fu Xiaobing,Han Weidong [他],Zhao Yali,Liu Huiling,Sheng Zhiyong
Biological and Pharmaceutical Bulletin 34(7), 1037-1045, 2011
… Moreover, these dedifferentiation-derived KSCs (dKSCs) showed an ability for high colony formation correlated with cell cycle analysis showing a marked accumulation in S phases, acquired a similar regional distribution of both α6-integrin and CD71 expression at the ultrastructural level, and had a increased proliferative capacity by releasing telomerase from nucleolar sites to nucleoplasmic distribution. …
NAID 130000738093

Micronuclei, nucleoplasmic bridges and nuclear buds induced in folic acid deficient human lymphocytes-evidence for breakage-fusion-bridge cycles in the cytokinesis-block micronucleus assay