English Journal

Effectiveness of activated carbon and Egyptian montmorillonite in the protection against deoxynivalenol-induced cytotoxicity and genotoxicity in rats.

Abdel-Wahhab MA1, El-Kady AA2, Hassan AM3, Abd El-Moneim OM4, Abdel-Aziem SH4.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.Food Chem Toxicol.2015 Sep;83:174-82. doi: 10.1016/j.fct.2015.06.015. Epub 2015 Jun 24.
This study was conducted to prepare and characterize activated carbon (AC) and to evaluate its protective effect against deoxynivalenol (DON) toxicity in rats compared to Egyptian montmorillonite (EM). AC was prepared using a single-step chemical activation with phosphoric acid (H3PO4). The resulted
PMID 26115597

Dietary folic acid protects against genotoxicity in the red blood cells of mice.

MacFarlane AJ1, Behan NA2, Field MS3, Williams A4, Stover PJ3, Yauk CL4.
Mutation research.Mutat Res.2015 Sep;779:105-11. doi: 10.1016/j.mrfmmm.2015.06.012. Epub 2015 Jun 29.
Folate is an essential B vitamin required for the de novo synthesis of purines, thymidylate and methionine. Folate deficiency can lead to mutations and genome instability, and has been shown to exacerbate the genotoxic potential of environmental toxins. We hypothesized that a folic acid (FA) deficie
PMID 26177356

Selective inhibition by aspirin and naproxen of mainstream cigarette smoke-induced genotoxicity and lung tumors in female mice.

Balansky R1, Ganchev G2, Iltcheva M3, Micale RT4, La Maestra S5, D'Oria C6, Steele VE7, De Flora S8.
Archives of toxicology.Arch Toxicol.2015 Jun 24. [Epub ahead of print]
The role of nonsteroidal anti-inflammatory drugs (NSAIDs) in smoke-related lung carcinogenesis is still controversial. We have developed and validated a murine model for evaluating the tumorigenicity of mainstream cigarette smoke (MCS) and its modulation by chemopreventive agents. In the present stu
PMID 26104855