English Journal
- A synthetic 18-norsteroid distinguishes between two neuroactive steroid binding sites on GABAA receptors.
- Evers AS, Chen ZW, Manion BD, Han M, Jiang X, Darbandi-Tonkabon R, Kable T, Bracamontes J, Zorumski CF, Mennerick S, Steinbach JH, Covey DF.SourceDepartment of Anesthesiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA. eversa@wustl.edu
- The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2010 May;333(2):404-13. Epub 2010 Feb 2.
- In the absence of GABA, neuroactive steroids that enhance GABA-mediated currents modulate binding of [35S]t-butylbicyclophosphorothionate in a biphasic manner, with enhancement of binding at low concentrations (site NS1) and inhibition at higher concentrations (site NS2). In the current study, compo
- PMID 20124410
- Hydrogen bonding between the 17beta-substituent of a neurosteroid and the GABA(A) receptor is not obligatory for channel potentiation.
- Li P, Bandyopadhyaya AK, Covey DF, Steinbach JH, Akk G.SourceDepartment of Anesthesiology, Washington University in St Louis, St Louis, MO 63110, USA.
- British journal of pharmacology.Br J Pharmacol.2009 Nov;158(5):1322-9. Epub 2009 Aug 20.
- BACKGROUND AND PURPOSE: Potentiating neurosteroids are some of the most efficacious modulators of the mammalian GABA(A) receptor. One of the crucial interactions may be between the C20 ketone group (D-ring substituent at C17) of the neurosteroid, and the N407 and Y410 residues in the M4 domain of th
- PMID 19702782
Related Links
- Therapeutically useful A-nor-androsta-3(5),16-dien-2-one ...
Related Pictures
