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English Journal

Suppression of Breast Cancer Cell Migration by Small Interfering RNA Delivered by Polyethylenimine-Functionalized Graphene Oxide.

Huang YP1, Hung CM2, Hsu YC3,4, Zhong CY5, Wang WR5, Chang CC6, Lee MJ7,8.
Nanoscale research letters.Nanoscale Res Lett.2016 Dec;11(1):247. doi: 10.1186/s11671-016-1463-0. Epub 2016 May 12.
The carbon-based nanomaterial graphene can be chemically modified to associate with various molecules such as chemicals and biomolecules and developed as novel carriers for drug and gene delivery. In this study, a nonviral gene transfection reagent was produced by functionalizing graphene oxide (GO)
PMID 27173676

Prolonged Three-Dimensional Co-Delivery of Yamanaka Factors for Cell Reprogramming.

Deng W1, Cao X1, Wang Q1, Wang Y1, Chen J1, Yu Q1, Zhang Z2, Zhou J1, Xu W1, Du P1, Chen J1, Gao X3, Yu J1, Xu X1.
ACS applied materials & interfaces.ACS Appl Mater Interfaces.2016 Aug 10;8(31):19916-27. doi: 10.1021/acsami.6b05825. Epub 2016 Jul 26.
Reprogramming somatic cells into a pluripotent state has been widely investigated in two-dimensional (2D) systems but not described in the more biologically faithful three-dimensional (3D) scaffolds. Here, we devise a 3D porous tissue engineering scaffold that could achieve successful and efficient
PMID 27428246

Incorporation of a Nuclear Localization Signal in pH Responsive LAH4-L1 Peptide Enhances Transfection and Nuclear Uptake of Plasmid DNA.

Xu Y1, Liang W1, Qiu Y1, Cespi M2, Palmieri GF2, Mason AJ3, Lam JK1.
Molecular pharmaceutics.Mol Pharm.2016 Aug 9. [Epub ahead of print]
The major intracellular barriers associated with DNA delivery using nonviral vectors are inefficient endosomal/lysosomal escape and poor nuclear uptake. LAH4-L1, a pH responsive cationic amphipathic peptide, is an efficient DNA delivery vector that promotes the release of nucleic acid into cytoplasm
PMID 27458925