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1. 固形臓器移植後の悪性腫瘍の発現 development of malignancy following solid organ transplantation

English Journal

Toll-like receptor 3 signaling enables human esophageal epithelial cells to sense endogenous danger signals released by necrotic cells.

Lim DM, Wang ML.SourceDivision of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, 902-E Abramson Research Bldg., 3615 Civic Center Blvd., Philadelphia, PA 19104 (email: wangm@email.chop.edu.
American journal of physiology. Gastrointestinal and liver physiology.Am J Physiol Gastrointest Liver Physiol.2011 Jul;301(1):G91-9. Epub 2011 Apr 7.
The mechanisms by which gastroesophageal reflux disease esophagitis develops are controversial. Although many support the notion that caustic injury leads to reflux esophagitis, others have proposed that reflux esophagitis is caused by esophageal epithelial cytokine-mediated inflammation. We previou
PMID 21474651

Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition.

Johnson N, Li YC, Walton ZE, Cheng KA, Li D, Rodig SJ, Moreau LA, Unitt C, Bronson RT, Thomas HD, Newell DR, D'Andrea AD, Curtin NJ, Wong KK, Shapiro GI.Source1] Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA. [2] Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Nature medicine.Nat Med.2011 Jun 26;17(7):875-82. doi: 10.1038/nm.2377.
Cells that are deficient in homologous recombination, such as those that lack functional breast cancer-associated 1 (BRCA1) or BRCA2, are hypersensitive to inhibition of poly(ADP-ribose) polymerase (PARP). However, BRCA-deficient tumors represent only a small fraction of adult cancers, which might r
PMID 21706030