Journal of virology.J Virol.2015 Nov 1;89(21):11169-73. doi: 10.1128/JVI.01781-15. Epub 2015 Aug 26.
It is well known that plasmid DNA transfection, prior to virus infection, negatively affects infection efficiency. Here, we show that cytosolic plasmid DNA activates the cGAS/STING signaling pathway, which ultimately leads to the induction of an antiviral state of the cells. Using a transient one-pl
Aberrantly regulated dysadherin and B-cell lymphoma 2/B-cell lymphoma 2-associated X enhances tumorigenesis and DNA targeting drug resistance of liver cancer stem cells.
Jiang N1, Chen W2, Zhang JW1, Li Y1, Zeng XC1, Zhang T1, Fu BS1, Yi HM1, Zhang Q1.
Molecular medicine reports.Mol Med Rep.2015 Sep 25. doi: 10.3892/mmr.2015.4363. [Epub ahead of print]
Cancer stem cells (CSCs) in hepatocellular carcinoma (HCC) are frequently resistant to current therapeutic regimens and therefore responsible for tumor recurrence. Previous studies have reported that expression levels of dysadherin in CSCs may be used as a prognostic indicator, which is also respons
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2015 Aug;59(8):4770-81. doi: 10.1128/AAC.04880-14. Epub 2015 Jun 1.
Cysteine metabolism is considered essential for the crucial maintenance of a reducing environment in trypanosomatids due to its importance as a precursor of trypanothione biosynthesis. Expression, activity, functional rescue, and overexpression of cysteine synthase (CS) and cystathionine β-synthase
Production of Transgenic Pigs Harboring the Human Erythropoietin (hEPO) Gene Using Somatic Cell Nuclear Transfer
CHO Seong-Keun,HWANG Kyu-Chan,CHOI Yun-Jung,BUI Hong-Thuy,NGUYEN Van Thuan,PARK ChangKyu,KIM Jae-Hwan,KIM Jin-Hoi
Journal of Reproduction and Development 55(2), 128-136, 2009
… The production of transgenic pigs using somatic cell nuclear transfer (scNT) has been widely described, but a technique for removing nontransfected donor cells and for creating different founder animals has not yet been fully elucidated. …
Radiation-Inducible TNF-α Gene Expression under Stress-Inducible Promoter gadd 153 for Cancer Therapy
Ito Akira,Shinkai Masashige,Hakamada Kazumi [他],HONDA HIROYUKI,KOBAYASHI TAKESHI
Journal of bioscience and bioengineering 92(6), 598-601, 2001-12-25
… The cytotoxicities against the transfected cells 5 d after irradiation with 10 and 20 Gy were 79% or 91%, respectively, which are much higher than those against the nontransfected cells that were irradiated at the same dose(43% and 78%, respectively). …
Nuclear transfer in cattle with non-transfected and transfected fetal or cloned transgenic fetal and postnatal fibroblasts. Zakhartchenko V, Mueller S, Alberio R, Schernthaner W, Stojkovic M, Wenigerkind H, Wanke R, Lassnig C, Mueller M, Wolf ...