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1. 蚊に刺されることで生じるアレルギー反応allergic reactions to mosquito bites [show details]
…Prevention of large local reactions consists of mosquito avoidance and prophylaxis with an oral nonsedating H1 antihistamine. Written information about insect repellents and environmental control measures …
2. アレルギー性結膜炎：マネージメントallergic conjunctivitis management [show details]
…used in the management of allergic conjunctivitis that is associated with nonocular symptoms. Nonsedating over-the-counter or prescription oral H1 antihistamines may be helpful for patients who also report …
3. 寒冷蕁麻疹cold urticaria [show details]
…frequency and severity of urticaria/angioedema episodes, as with other forms of chronic urticaria . Nonsedating second-generation H1 antihistamines are preferred for chronic treatment, although some of these …
4. 新規発症の蕁麻疹new onset urticaria [show details]
…fruit juices. There are additional nonsedating antihistamines that are available in many countries, although not in the United States: Ebastine – Ebastine is a nonsedating antihistamine that is licensed for …
5. 慢性特発性蕁麻疹：標準的なマネージメントおよび患者教育chronic spontaneous urticaria standard management and patient education [show details]
…clinical history to detect and minimize aggravating factors, followed by initial treatment with nonsedating, second-generation H1 antihistamines. If symptoms persist, most guidelines suggest increasing the …

English Journal

Cholinergic urticaria with anaphylaxis: hazardous duty of a deployed US marine.

Handfield KS1, Dolan CK, Kaplan M.
Cutis.Cutis.2015 Apr;95(4):241-3.
Cholinergic urticaria (CU) is triggered by a rise in body temperature and can be complicated by bronchial hyperresponsiveness and anaphylaxis. It primarily affects young adults who actively engage in strenuous exercise, such as servicemen and servicewomen. If the patient reports a history of wheezin
PMID 25942027

A long-standing mystery solved: the formation of 3-hydroxydesloratadine is catalyzed by CYP2C8 but prior glucuronidation of desloratadine by UDP-glucuronosyltransferase 2B10 is an obligatory requirement.

Kazmi F1, Barbara JE2, Yerino P2, Parkinson A2.
Drug metabolism and disposition: the biological fate of chemicals.Drug Metab Dispos.2015 Apr;43(4):523-33. doi: 10.1124/dmd.114.062620. Epub 2015 Jan 16.
Desloratadine (Clarinex), the major active metabolite of loratadine (Claritin), is a nonsedating long-lasting antihistamine that is widely used for the treatment of allergic rhinitis and chronic idiopathic urticaria. For over 20 years, it has remained a mystery as to which enzymes are responsible fo
PMID 25595597

Long-Term Antihyperalgesic and Opioid-Sparing Effects of 5-Day Ketamine and Morphine Infusion ("Burst Ketamine") in Diabetic Neuropathic Rats.

Mak P1, Broadbear JH, Kolosov A, Goodchild CS.
Pain medicine (Malden, Mass.).Pain Med.2015 Mar 20. doi: 10.1111/pme.12735. [Epub ahead of print]
BACKGROUND: "Burst ketamine" (BK) is the long-term infusion of subanesthetic ketamine in combination with an opioid. It is used clinically with mixed success to provide long-term pain relief and improve opioid response in patients. BK has not been simulated preclinically, therefore, its effectivenes
PMID 25800174