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1. T細胞受容体の遺伝学 t cell receptor genetics
2. 結核の自然史、微生物学、および病因 natural history microbiology and pathogenesis of tuberculosis
3. B型肝炎ウイルス感染の臨床症状および自然経過 clinical manifestations and natural history of hepatitis b virus infection

English Journal

Reduced Drug Uptake in Phenotypically Resistant Nutrient-Starved Nonreplicating Mycobacterium tuberculosis.

Sarathy J, Dartois V, Dick T, Gengenbacher M.SourceNovartis Institute for Tropical Diseases, Biopolis, Singapore.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Apr;57(4):1648-53. doi: 10.1128/AAC.02202-12. Epub 2013 Jan 18.
During active tuberculosis a spectrum of physiologically different Mycobacterium tuberculosis bacilli reside in human tissues. Subpopulations of the pathogen survive antibiotic treatment for a prolonged time in a dormant state of phenotypic drug resistance, a phenomenon independent of genetic mutati
PMID 23335744

Murphy AM, Rabkin SD.SourceBrain Tumor Research Center, Molecular Neurosurgery Laboratory, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, Mass.
Translational research : the journal of laboratory and clinical medicine.Transl Res.2013 Apr;161(4):339-54. doi: 10.1016/j.trsl.2012.11.003. Epub 2012 Dec 11.
Glioblastoma (GBM) is the most common and deadliest primary brain tumor in adults, with current treatments having limited impact on disease progression. Therefore the development of alternative treatment options is greatly needed. Gene therapy is a treatment strategy that relies on the delivery of g
PMID 23246627

Aminopyrazinamides: Novel and Specific GyrB Inhibitors that Kill Replicating and Nonreplicating Mycobacterium tuberculosis.

Shirude PS, Madhavapeddi P, Tucker JA, Murugan K, Patil V, Basavarajappa H, Raichurkar AV, Humnabadkar V, Hussein S, Sharma S, Ramya VK, Narayan CB, Balganesh TS, Sambandamurthy VK.SourceDepartment of Medicinal Chemistry and ‡Department of Biosciences, AstraZeneca India Pvt. Ltd. , Bellary Road, Hebbal, Bangalore 560024, India.
ACS chemical biology.ACS Chem Biol.2013 Mar 15;8(3):519-23. doi: 10.1021/cb300510w. Epub 2012 Dec 31.
Aminopyrazinamides originated from a high throughput screen targeting the Mycobacterium smegmatis (Msm) GyrB ATPase. This series displays chemical tractability, robust structure-activity relationship, and potent antitubercular activity. The crystal structure of Msm GyrB in complex with one of the am
PMID 23268609

PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release

Priming-boosting vaccination with recombinant Mycobacterium bovis bacillus Calmette-Guerin and a nonreplicating vaccinia virus recombinant leads to long-lasting and effective immunity