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1. ST上昇型心筋梗塞における血栓溶解療法の特性および臨床試験 characteristics of fibrinolytic thrombolytic agents and clinical trials in acute st elevation myocardial infarction
2. 組換え造血成長因子の概要 introduction to recombinant hematopoietic growth factors
3. 血小板産生因子の臨床応用 clinical applications of thrombopoietic growth factors
4. 妊娠中や授乳中の女性のリウマチ性疾患に用いる抗炎症薬と免疫抑制剤の安全性 safety of antiinflammatory and immunosuppressive drugs in rheumatic diseases during pregnancy and lactation

English Journal

Culbertson AT1, Chou YH1, Smith AL1, Young ZT1, Tietze AA1, Cottaz S1, Fauré R1, Zabotina OA2.
Plant physiology.Plant Physiol.2016 Jul;171(3):1893-904. doi: 10.1104/pp.16.00361. Epub 2016 May 20.
Xyloglucan, the most abundant hemicellulosic component of the primary cell wall of flowering plants, is composed of a β-(1,4)-glucan backbone decorated with d-xylosyl residues. Three xyloglucan xylosyltransferases (XXTs) participate in xyloglucan biosynthesis in Arabidopsis (Arabidopsis thaliana).
PMID 27208276

N-Glycosylation of Human R-Spondin 1 Is Required for Efficient Secretion and Stability but Not for Its Heparin Binding Ability.

Chang CF1, Hsu LS2,3, Weng CY4, Chen CK5, Wang SY6, Chou YH7, Liu YY8, Yuan ZX9, Huang WY10, Lin H11, Chen YH12, Tsai JN13,14.
International journal of molecular sciences.Int J Mol Sci.2016 Jun 14;17(6). pii: E937. doi: 10.3390/ijms17060937.
R-spondin 1 (Rspo1) plays an essential role in stem cell biology by potentiating Wnt signaling activity. Despite the fact that Rspo1 holds therapeutic potential for a number of diseases, its biogenesis is not fully elucidated. All Rspo proteins feature two amino-terminal furin-like repeats, which ar
PMID 27314333

Production in Pichia pastoris of complementary protein-based polymers with heterodimer-forming WW and PPxY domains.

Domeradzka NE1,2, Werten MW3, de Vries R2, de Wolf FA1.
Microbial cell factories.Microb Cell Fact.2016 Jun 10;15(1):105. doi: 10.1186/s12934-016-0498-3.
BACKGROUND: Specific coupling of de novo designed recombinant protein polymers for the construction of precisely structured nanomaterials is of interest for applications in biomedicine, pharmaceutics and diagnostics. An attractive coupling strategy is to incorporate specifically interacting peptides
PMID 27286861

Molecular Cloning and Characterization of Cystatin, a Cysteine Protease Inhibitor, from Bufo melanostictus

, , [他], , ,
Bioscience, Biotechnology, and Biochemistry 77(10), 2077-2081, 2013
… The single nonglycosylated polypeptide chain of Cystatin-X consisted of 102 amino acid residues, including seven cysteines. …
NAID 130003381890

KONDO Jun,SHIBATA Hiroyuki,MIURA Shigenori,YAMAKAWA Akira,SATO Koji,HIGUCHI Yoshiki,SHUKUNAMI Chisa,HIRAKI Yuji
Journal of bone and mineral metabolism 29(1), 23-30, 2011-01-30
… We generated a nonglycosylated recombinant human ChM-I (NG-hChM-I) and compared its bioactivity with that of the glycosylated form of human ChM-I (G-hChM-I) expressed in Chinese hamster ovary cells in vitro. …
NAID 10029023545

Cysteine-to-serine shuffling using a Saccharomyces cerevisiae expression system improves protein secretion: case of a nonglycosylated mutant of miraculin, a taste-modifying protein.

Ito Keisuke,Sugawara Taishi,Koizumi Ayako,Nakajima Ken-ichiro,Shimizu-Ibuka Akiko,Shiroishi Mitsunori,Asada Hidetsugu,Yurugi-Kobayashi Takami,Shimamura Tatsuro,Asakura Tomiko,Misaka Takumi,Iwata So,Kobayashi Takuya,Abe Keiko
Biotechnology letters 33(1), 103-107, 2011-01
… In the case of a nonglycosylated mutant of the taste-modifying protein miraculin (MCL), which was used here as a model protein, 25% of all constructs obtained from CS shuffling expressed MCL mutant, and serine mutations were found at Cys47 or Cys92, which are involved in the formation of the disulfide bond. …
NAID 120002723145