WordNet
- someone who has announced they are not a candidate; especially a politician who has announced that he or she is not a candidate for some political office
English Journal
- Polymorphism at genes involved in salt tolerance in Arabidopsis thaliana (Brassicaceae).
- Puerma E1, Aguadé M.Author information 1Departament de Genètica, Facultat de Biologia, i Institut de Recerca de la Biodiversitat, Universitat de Barcelona, Diagonal 643, 08028 Barcelona, Spain.AbstractPREMISE OF THE STUDY: Genes involved in relevant functions for environmental adaptation can be considered primary candidates for their variation having been shaped by natural selection. Detecting recent selective events through their footprint on nucleotide variation constitutes a challenging task in species with a complex demographic history such as Arabidopsis thaliana. We have surveyed nucleotide variation in this species at nine genes involved in salt tolerance. The available genomewide information for this species has allowed us to contrast the levels and patterns of variation detected at the candidate genes with empirical distributions obtained from noncandidate regions.
- American journal of botany.Am J Bot.2013 Feb;100(2):384-90. doi: 10.3732/ajb.1200332. Epub 2013 Jan 23.
- PREMISE OF THE STUDY: Genes involved in relevant functions for environmental adaptation can be considered primary candidates for their variation having been shaped by natural selection. Detecting recent selective events through their footprint on nucleotide variation constitutes a challenging task i
- PMID 23345415
- Identification of novel biomarkers of abdominal aortic aneurysms by 2D-DIGE and MALDI-MS from AAA-thrombus-conditioned media.
- Martinez-Pinna R1, Lopez JA, Ramos-Mozo P, Blanco-Colio LM, Camafeita E, Calvo E, Meilhac O, Michel JB, Egido J, Martin-Ventura JL.Author information 1Vascular Research Lab IIS-Fundación Jiménez Díaz, Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz (IIS-FJD), Universidad Autónoma de Madrid, Madrid, Spain.AbstractIn the search for novel biomarkers, noncandidate-based proteomic strategies open up new opportunities to gain a deeper insight into disease processes regarding their molecular mechanisms, the risk factors involved, and the monitoring of disease progression. To carry out these complex analyses, the combined use of gel electrophoresis with mass spectrometry (MS) represents a powerful choice. In addition, the introduction of protein dye labeling has notably improved the reliability of differential expression studies by increasing the statistical significance of the protein candidates. Here, we describe a strategy where different layers (luminal/abluminal) from the intraluminal thrombus (ILT) of human abdominal aortic aneurysm (AAA) patients were incubated in protein-free medium. Then, the levels of the proteins released were compared by two-dimensional differential in-gel electrophoresis (2D-DIGE) and the proteins of interest identified by MS. We consider that the use of tissue-conditioned media could offer a substantial advantage in the analytical study of biological fluids, as they provide a source of proteins to be released to the bloodstream, which could serve as potential circulating biomarkers.
- Methods in molecular biology (Clifton, N.J.).Methods Mol Biol.2013;1000:91-101. doi: 10.1007/978-1-62703-405-0_8.
- In the search for novel biomarkers, noncandidate-based proteomic strategies open up new opportunities to gain a deeper insight into disease processes regarding their molecular mechanisms, the risk factors involved, and the monitoring of disease progression. To carry out these complex analyses, the c
- PMID 23585087
- Large-scale candidate gene scan reveals the role of chemoreceptor genes in host plant specialization and speciation in the pea aphid.
- Smadja CM1, Canbäck B, Vitalis R, Gautier M, Ferrari J, Zhou JJ, Butlin RK.Author information 1Centre National de la Recherche Scientifique CNRS-Institut des Sciences de l'Evolution UMR 5554, cc065 Université Montpellier 2, 34095 Montpellier, France. carole.smadia@univ-montp2.frAbstractUnderstanding the drivers of speciation is critical to interpreting patterns of biodiversity. The identification of the genetic changes underlying adaptation and reproductive isolation is necessary to link barriers to gene flow to the causal origins of divergence. Here, we present a novel approach to the genetics of speciation, which should complement the commonly used approaches of quantitative trait locus mapping and genome-wide scans for selection. We present a large-scale candidate gene approach by means of sequence capture, applied to identifying the genetic changes underlying reproductive isolation in the pea aphid, a model system for the study of ecological speciation. Targeted resequencing enabled us to scale up the candidate gene approach, specifically testing for the role of chemosensory gene families in host plant specialization. Screening for the signature of divergence under selection at 172 candidate and noncandidate loci, we revealed a handful of loci that show high levels of differentiation among host races, which almost all correspond to odorant and gustatory receptor genes. This study offers the first indication that some chemoreceptor genes, often tightly linked together in the genome, could play a key role in local adaptation and reproductive isolation in the pea aphid and potentially other phytophagous insects. Our approach opens a new route toward the functional genomics of ecological speciation.
- Evolution; international journal of organic evolution.Evolution.2012 Sep;66(9):2723-38. doi: 10.1111/j.1558-5646.2012.01612.x. Epub 2012 Apr 12.
- Understanding the drivers of speciation is critical to interpreting patterns of biodiversity. The identification of the genetic changes underlying adaptation and reproductive isolation is necessary to link barriers to gene flow to the causal origins of divergence. Here, we present a novel approach t
- PMID 22946799
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- Noncandidate definition, a person who has not yet announced his or her availability for election to a political office or who has declared himself or herself not a candidate. See more. Dictionary.com Word of the Day Translate Games ...
- Definition of NONCANDIDATE: a person who is not a candidate; especially: one who has refused to be a candidate for a particular political office — non · can · di · da · cy \-də-sē\ noun ADVERTISEMENT First Known Use of NONCANDIDATE
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