noggin

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/12/25 14:22:47」(JST)

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Recombinant human bone morphogenetic protein-9 potently induces osteogenic differentiation of human periodontal ligament fibroblasts.

Fuchigami S1, Nakamura T1, Furue K1, Sena K1, Shinohara Y1, Noguchi K1,2.
European journal of oral sciences.Eur J Oral Sci.2016 Apr;124(2):151-7. doi: 10.1111/eos.12249. Epub 2016 Feb 16.
To accomplish effective periodontal regeneration for periodontal defects, several regenerative methods using growth and differentiation factors, including bone morphogenetic proteins (BMPs), have been developed. Bone morphogenetic protein-9 exhibits the most potent osteogenic activity of this growth
PMID 26879145

Noggin4 is a long-range inhibitor of Wnt8 signalling that regulates head development in Xenopus laevis.

Eroshkin FM1, Nesterenko AM1,2, Borodulin AV1, Martynova NY1, Ermakova GV1, Gyoeva FK3, Orlov EE1, Belogurov AA1, Lukyanov KA1, Bayramov AV1, Zaraisky AG1.
Scientific reports.Sci Rep.2016 Mar 14;6:23049. doi: 10.1038/srep23049.
Noggin4 is a Noggin family secreted protein whose molecular and physiological functions remain unknown. In this study, we demonstrate that in contrast to other Noggins, Xenopus laevis Noggin4 cannot antagonise BMP signalling; instead, it specifically binds to Wnt8 and inhibits the Wnt/β -catenin pa
PMID 26973133

Comparison of newly developed anti-bone morphogenetic protein 4 llama-derived antibodies with commercially available BMP4 inhibitors.

Calpe S1, Correia AC1, Sancho-Serra MD1, Krishnadath KK1,2.
mAbs.MAbs.2016 Mar 11:0. [Epub ahead of print]
Due to improved understanding of the role of bone morphogenetic protein 4 (BMP4) in an increasing number of diseases, the development of selective inhibitors of BMP4 is an attractive therapeutic option. The currently available BMP4 inhibitors are not suitable as therapeutics because of their low spe
PMID 26967714

Transplantation of Motor Neurons Derived from Human iPS Cells into Total Transection Model of Spinal Cord Injury in Mice

Shamma Awad,Suzuki Misa,Hayashi Naoyuki,Kobayashi Masahiko,Sasaki Nobunari,Nishiuchi Takumi,Doki Yuichiro,Okamoto Takahiro,Kohno Susumu,Muranaka Hayato,Kitajima Shunsuke,Yamamoto Ken-ichi,Takahashi Chiaki
Molecular biology of the cell 33(16), 3113-3124, 2013-08
… Here we report that the genetic interaction of Rb and ATM regulates DNMT1 protein stability and hence controls the DNA methylation status in the promoters of at least the Ink4a, Shc2, FoxO6, and Noggin genes. …
NAID 120005312327