English Journal

Dieb W1,2,3, Ouachikh O4, Alves S5, Boucher Y6,7, Durif F8,9, Hafidi A10.
The journal of headache and pain.J Headache Pain.2016 Dec;17(1):11. doi: 10.1186/s10194-016-0607-z. Epub 2016 Feb 17.
BACKGROUND: This study investigated mesencephalic dopamine depletion effects on static mechanical allodynia (SMA) elicited by chronic constriction of the infraorbitary nerve (CCI-IoN).METHODS: Dopamine depletion (6-OHDA administration into the medial forebrain bundle) effects on CCI-IoN-induced SMA
PMID 26885825

Substituted galacturonan from starfruit: Chemical structure and antinociceptive and anti-inflammatory effects.

Leivas CL1, Nascimento LF2, Barros WM2, Santos AR2, Iacomini M1, Cordeiro LM3.
International journal of biological macromolecules.Int J Biol Macromol.2016 Mar;84:295-300. doi: 10.1016/j.ijbiomac.2015.12.034. Epub 2015 Dec 17.
Starfruit (Averrhoa carambola L.) is an edible tropical fruit, which is usually consumed as a fresh table fruit or as fruit juice. It also exhibits various pharmacological activities. In this study, polysaccharides were extracted with boiling water and purified by freeze-thawing and Fehling treatmen
PMID 26706843

NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats.

Munro G1, Christensen JK1, Erichsen HK1, Dyhring T1,2, Demnitz J1, Dam E1, Ahring PK1,2,3.
CNS neuroscience & therapeutics.CNS Neurosci Ther.2016 Feb;22(2):135-45. doi: 10.1111/cns.12487. Epub 2015 Dec 10.
AIMS: Here, we investigate the pharmacology of NS383, a novel small molecule inhibitor of acid-sensing ion channels (ASICs).METHODS: ASIC inhibition by NS383 was characterized in patch-clamp electrophysiological studies. Analgesic properties were evaluated in four rat behavioral models of pain.RESUL
PMID 26663905

Japanese Journal

TRPM2 Contributes to Inflammatory and Neuropathic Pain through the Aggravation of Pronociceptive Inflammatory Responses in Mice.

Haraguchi Kayo,Kawamoto Ai,Isami Kouichi,Maeda Sanae,Kusano Ayaka,Asakura Kayoko,Shirakawa Hisashi,Mori Yasuo,Nakagawa Takayuki,Kaneko Shuji
The Journal of neuroscience : the official journal of the Society for Neuroscience 32(11), 3931-3941, 2012-03-14
… While wild-type and TRPM2 knock-out mice showed no difference in their basal sensitivity to mechanical and thermal stimulation, nocifensive behaviors in the formalin test were reduced in TRPM2 knock-out mice. …
NAID 120003987901

Central serotonin 3 receptors play an important role in the modulation of nociceptive neural activity of trigeminal subnucleus caudalis and nocifensive orofacial behavior in rats with persistent temporomandibular joint inflammation