nociceptin

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/09/03 12:28:20」(JST)

wiki en

[Wiki en表示]

Nociceptin
Other names Orphanin FQ
Identifiers
CAS number	170713-75-4 Y
PubChem	16131448
MeSH	nociceptin
ChEMBL	CHEMBL396460 Y
IUPHAR ligand	1681
Properties
Molecular formula	C79H129N27O22
Molar mass	1809.04
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Y (verify) (what is: Y/N?)
Infobox references

prepronociceptin
Identifiers
Symbol	PNOC
Entrez	5368
HUGO	9163
OMIM	601459
RefSeq	NM_006228
UniProt	Q13519
Other data
Locus	Chr. 8 p21

Nociceptin or orphanin FQ, a 17-amino acid neuropeptide, is the endogenous ligand for the nociceptin receptor (NOP, ORL-1). It is derived from the prepronociceptin protein, as are a further 2 peptides, nocistatin & NocII. The gene coding for prepronociceptin is located on Ch8p21 in humans.

Nociceptin is an opioid-related peptide, but it does not act at the classic opioid receptors (namely, mu, kappa, and delta opioid receptors), and its actions are not antagonized by the opioid antagonist naloxone. Nociceptin is a potent anti-analgesic. Nociceptin is widely distributed in the CNS; it is found in many regions of the hypothalamus, brainstem, and forebrain, as well as in the ventral horn and dorsal horn of the spinal cord. Nociceptin acts at the Nociceptin receptor (NOP1), formerly known as ORL-1. The receptor is also widely distributed in the brain, including in the cortex, anterior olfactory nucleus, lateral septum, hypothalamus, hippocampus, amygdala, central gray, pontine nuclei, interpeduncular nucleus, substantia nigra, raphe complex, locus coeruleus, and spinal cord.

The N/OFQ-NOP system is found in central and peripheral nervous tissue, where it is well placed to modulate nociception. Indeed, there is some evidence that nociceptin may be involved in the phenomenon of opioid-induced hyperalgesia.

References

External links

• nociceptin at the US National Library of Medicine Medical Subject Headings (MeSH)
• prepronociceptin at the US National Library of Medicine Medical Subject Headings (MeSH)

English Journal

• Cebranopadol : a first-in-class potent analgesic agent with agonistic activity at nociceptin/orphanin FQ and opioid receptors.

• Sałat K1, Jakubowska A, Kulig K.
• Expert opinion on investigational drugs.Expert Opin Investig Drugs.2015 Jun;24(6):837-44. doi: 10.1517/13543784.2015.1036985. Epub 2015 Apr 12.
• INTRODUCTION: Pain is a syndrome of various clinical disorders, which arises from various pathological conditions and which presents significant challenges in both its diagnosis and treatment. There is currently a strong medical demand to develop new therapies with a higher efficacy and a better tol
• PMID 25865744

• Low-dose Nociceptin/Orphanin FQ reduces anxiety-like performance in alcohol-withdrawn, but not alcohol-naïve, Male Wistar rats.

• Aujla H1, Nedjadrasul D2.
• Neuropharmacology.Neuropharmacology.2015 Jun;93:1-6. doi: 10.1016/j.neuropharm.2015.01.006. Epub 2015 Jan 21.
• Alcohol withdrawal is associated with neuroadaptation of stress-regulatory systems, including transmission of neuropeptides that have been implicated in anxiety-like performance. Nociceptin/Orphanin FQ (N/OFQ), an endogenous neuropeptide ligand at the NOP receptor, has been implicated in stress and
• PMID 25617519

• Three Homology Models of PAR2 Derived from Different Templates: Application to Antagonist Discovery.

• Perry SR1, Xu W1, Wirija A1, Lim J1, Yau MK1, Stoermer MJ1, Lucke AJ1, Fairlie DP1.
• Journal of chemical information and modeling.J Chem Inf Model.2015 May 22. [Epub ahead of print]
• Protease activated receptor 2 (PAR2) is an unusual G-protein coupled receptor (GPCR) involved in inflammation and metabolism. It is activated through cleavage of its N-terminus by proteases. The new N-terminus functions as a tethered ligand that folds back and intramolecularly activates PAR2, initia
• PMID 26000704

Japanese Journal

• 痛覚と鎮痛の研究39年を振り返って

• 倉石 泰
• YAKUGAKU ZASSHI 134(11), 1125-1142, 2014
• … We have demonstrated that nitric oxide, prostaglandin E2, and galectin-3 are involved in herpetic allodynia, that risk factors associated with postherpetic allodynia include severe herpetic pain, nociceptin, and major histocompatibility complex, and that deafferentation and nitric oxide are involved in postherpetic allodynia. …
• NAID 130004712975

• The effect of serotonergic system on nociceptin/orphanin FQ induced food intake in chicken

• ZENDEHDEL Morteza,MOKHTARPOURIANI Kasra,BABAPOUR Vahab,BAGHBANZADEH Ali,POURRAHIMI Maryam,HASSANPOUR Shahin
• The journal of physiological sciences : JPS 63(4), 271-277, 2013-07-01
• NAID 10031184280

• The effect of serotonergic system on nociceptin/orphanin FQ induced food intake in chicken

• Zendehdel Morteza,Mokhtarpouriani Kasra,Babapour Vahab [他]
• The journal of physiological sciences 63(4), 271-277, 2013-07
• NAID 40019680212

Related Links

• 痛みと鎮痛の基礎知識 - Pain Relief

ノシセプチン/オーファニンFQ nociceptin/orphanin FQ : N/OFQ 17個のアミノ酸から構成されるオピオイド様新規ペプチド Phe-Gly-Gly-Phe-Thr-Gly-Ala-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln-OH ノシセプチンの発見の前に、まず受容体が ...

• Structure of the nociceptin/orphanin FQ receptor in complex ...

Members of the opioid receptor family of G-protein-coupled receptors (GPCRs) are found throughout the peripheral and central nervous system, where they have key roles in nociception and analgesia. Unlike the /`classical/' opioid ...

Related Pictures

---

★リンクテーブル★

リンク元

「ノシセプチン」

「ノシセプチン」

　　[★]

英

nociceptin

• オピオイド受容体類似受容体が見つかり、そのアゴニストとしてノシセプチンが単離された。
• ノシセプチンは1995 年に発見された17 個のアミノ酸から構成されるオピオイド様新規ペプチドであり、痛覚過敏反応という他のオピオイドとは相反する作用を引き起こすことが最初に報告された。

http://www.banyuzaidan.or.jp/symp/about/symposium_2002/symp_yakuri/pages/yaluri_pdf/poster_presentation01.pdf より