- 関
- nitrergic
English Journal
- Central hemodynamics in prehypertension: effect of the β-adrenergic antagonist nebivolol.
- Davis JT1, Pasha DN, Khandrika S, Fung MM, Milic M, O'Connor DT.Author information 1Department of Medicine, VA San Diego Healthcare System and the University of California, San Diego, CA 92093, USA. jasontdavis18@gmail.comAbstractThe aim of the current study was to characterize the effects of the novel β-adrenergic antagonist nebivolol on central aortic blood pressures, arterial properties, and nitroxidergic activity in individuals with prehypertension. Prehypertension is emerging as a major risk factor for several adverse cardiovascular consequences. Increased pulse wave velocity, aortic augmentation index, and aortic blood pressures have been linked with augmented risk of cardiovascular disease and mortality. While the effects of antihypertensive drugs on these parameters in hypertensive patients have been studied, there are limited data so far in prehypertension. Fifty individuals with prehypertension were randomized to either nebivolol (5 mg per day) or placebo in a double-blind clinical trial. Patients underwent measurement of pulse wave velocity as well as aortic blood pressure and aortic augmentation index via pulse wave analysis at baseline and 8 weeks. Patients also had blood and urine biochemistries done at each visit. Nebivolol achieved significant reductions in central aortic systolic (P=.011), diastolic (P=.009), and mean arterial blood pressure (P=.002). Pulse wave velocity trended toward improvement but did not achieve significance (P=.088). Nitric oxide production, measured as urinary nitrite/nitrite excretion, also rose substantially in the nebivolol group (by approximately 60%, P=.030). Central blood pressures can be effectively lowered by β-blockade while patients are still in the prehypertension phase, and the effects may be coupled to improve nitric oxide release by the drug.
- Journal of clinical hypertension (Greenwich, Conn.).J Clin Hypertens (Greenwich).2013 Jan;15(1):69-74. doi: 10.1111/jch.12031. Epub 2012 Oct 26.
- The aim of the current study was to characterize the effects of the novel β-adrenergic antagonist nebivolol on central aortic blood pressures, arterial properties, and nitroxidergic activity in individuals with prehypertension. Prehypertension is emerging as a major risk factor for several adverse
- PMID 23282127
- Reticular groove of the domestic ruminants: histochemical and immunocytochemical study.
- Scala G1, Maruccio L.Author information 1Department of Biological Structures, Functions and Technologies, University of Naples Federico II, Italy. gaescala@unina.itAbstractThe reticular groove mucosa of adult cattle, buffalo and sheep was investigated by histochemical and immunocytochemical techniques. Intense NADPH-d staining was observed in the folds of the epithelium mucosa and at the bottom of the reticular groove in all domestic ruminants studied. The NADPH-d staining showed that the innervations of the tunica muscularis of the reticular groove lip were composed of nerve corpuscles, nerve fibres and nerve cells of the mucosa epithelium. SEM analysis showed an intense nitric oxide synthase (NOS) I immunoreactivity in deep and medium cellular layers. It is interesting to note that the same morphologies were observed in samples of the mucosa epithelium, and of the tunica muscularis processed by NADPH-d and in those processed by immunogold techniques. This study has demonstrated that nitric oxide (NO) is involved in the rumination activity and that it plays a double role in this activity in the reticular groove of all domestic ruminants studied: (1) NO plays a role similar to the one it has in the mucosa epithelium of all the other compartments of the ruminant forestomach, (2) The lip sections of the reticular groove has shown abundant innervations that may indirectly coordinate and control the forestomach motility through the direct activation of the nitrergic (nitroxidergic) nerve cells and nerve fibres.
- Anatomia, histologia, embryologia.Anat Histol Embryol.2012 Dec;41(6):428-35. doi: 10.1111/j.1439-0264.2012.01153.x. Epub 2012 Apr 17.
- The reticular groove mucosa of adult cattle, buffalo and sheep was investigated by histochemical and immunocytochemical techniques. Intense NADPH-d staining was observed in the folds of the epithelium mucosa and at the bottom of the reticular groove in all domestic ruminants studied. The NADPH-d sta
- PMID 22506730
- Enhancement of rostral ventrolateral medulla neuronal nitric-oxide synthase-nitric-oxide signaling mediates the central cannabinoid receptor 1-evoked pressor response in conscious rats.
- Ibrahim BM1, Abdel-Rahman AA.Author information 1Department of Pharmacology and Toxicology, Brody School of Medicine, East Carolina University, Greenville, NC 27834, USA.AbstractOur recent studies implicated brainstem GABAergic signaling in the central cannabinoid receptor 1 (CB(1)R)-mediated pressor response in conscious rats. Given the well established link between neuronal nitric-oxide synthase (nNOS)/nitric oxide (NO) signaling and GABAergic transmission in brainstem cardiovascular regulating areas, we elucidated the role of nNOS-generated NO in the central CB(1)R-elicited pressor response. Compared with vehicle, intracisternal (i.c.) microinjection of the CB(1)R agonist (R)-(+)-[2,3-dihydro-5-methyl-3[(4-morpholinyl)methyl]pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl) methanone mesylate (WIN55212-2) (15 μg/rat) significantly enhanced nNOS phosphorylation as well as the total nitrate and nitrite content in the rostral ventrolateral medulla (RVLM) at 5, 10, and 30 min, which paralleled the elicited pressor response. These findings were corroborated by: 1) the parallel dose-related increases in blood pressure and RVLM-NO levels, measured in real time by in vivo electrochemistry, elicited by intra-RVLM WIN55212-2 (100, 200, or 300 pmol /80 nl; n = 5) in conscious rats; and 2) the significantly higher phosphorylated nNOS (p-nNOS) levels in the WIN55212-2-injected RVLM compared with the contralateral RVLM. Subsequent neurochemical studies showed that WIN55212-2 (15 μg/rat i.c.) significantly increased the number and percentage of neurons immunostained for nNOS (nitroxidergic neurons) and c-Fos (marker of neuronal activity) within the RVLM. The increases in blood pressure and the neurochemical responses elicited by intracisternal WIN55212-2 were attenuated by prior central CB(1)R blockade by N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251; 30 μg/rat i.c.) or selective nNOS inhibition by N(ω)-propyl-(L)-arginine (1 μg/rat i.c.). These findings implicate RVLM p-nNOS/NO signaling as a molecular mechanism in the central CB(1)R-evoked pressor effect in conscious rats.
- The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2012 Jun;341(3):579-86. doi: 10.1124/jpet.112.192369. Epub 2012 Feb 24.
- Our recent studies implicated brainstem GABAergic signaling in the central cannabinoid receptor 1 (CB(1)R)-mediated pressor response in conscious rats. Given the well established link between neuronal nitric-oxide synthase (nNOS)/nitric oxide (NO) signaling and GABAergic transmission in brainstem ca
- PMID 22366659
Japanese Journal
- Altered nitroxidergic and NMDA receptor-mediated modulation of baroreflex-mediated heart rate in obese Zucker rats
- CHEN Jwo-Sheng,WANG Hui-Ju,CHANG Weng-Cheng,JAO Chin-Ci,WU Bor-Tsang,SHYU Woei-Cherng,LEE Shin-Da
- Hypertension research : clinical and experimental : official journal of the Japanese Society of Hypertension 33(9), 932-936, 2010-09-01
- NAID 10026711191
- Exposure to aluminium changes the NADPH-diaphorase/ NPY pattern in the rat cerebral cortex
- Rodella L. F.,Ricci F.,Borsani E.,Rezzani R.,Stacchiotti A.,Mariani C.,Bianchi R.
- Archives of Histology and Cytology 69(1), 13-21, 2006
- … Aluminium (Al) impairs the glutamate-nitric oxide-cGMP pathway and reduces the number of nitroxidergic neurons in the rat somatosensory cortex. … To understand better the effect of the time of exposure, we monitored the effect of aluminium administration on nitroxidergic neurons, identified by NADPH-diaphorase (NADPH-d) or by nitric oxide synthase (NOS) staining, after 0.5, 1, 2, 3, 6 and 12 months of aluminium administration. …
- NAID 130004462661
- Protection by Hypothermia of Hypoxia-Induced Ingibition of Neurogenin Vasodilation in Porcine Cerebral Arteries
- Tanaka Toshiki,Ayajiki Kazuhide,Fujioka Hideyuki [他],TODA Noboru,OKAMURA Tomio
- Journal of pharmacological sciences 92(2), 93-99, 2003-06-01
- … It is concluded that hypothermia augments vasodilatation associated with nitroxidergic (nitrergic) nerve activation possibly by increasing the production of NO from <sc><font size = -2>L</font></sc>-arginine and, in addition, prevents impairment of NO production by hypoxia. …
- NAID 10011232083
Related Links
- 15 Jan 1997 ... Modification by endogenous or exogenous acetylcholine and vasoactive intestinal polypeptide (VIP) of vasodilatation mediated by nitric oxide (NO) released from nitroxidergic nerves was studied in isolated monkey cerebral ...
★リンクテーブル★
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- 関
- nitroxidergic
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- 英
- nitrergic、nitroxidergic