nitrosomethylurethane

English Journal

Characterization of the serotonin transporter knockout rat: a selective change in the functioning of the serotonergic system.

Homberg JR, Olivier JD, Smits BM, Mul JD, Mudde J, Verheul M, Nieuwenhuizen OF, Cools AR, Ronken E, Cremers T, Schoffelmeer AN, Ellenbroek BA, Cuppen E.SourceHubrecht Laboratory, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands.
Neuroscience.Neuroscience.2007 Jun 8;146(4):1662-76. Epub 2007 Apr 30.
Serotonergic signaling is involved in many neurobiological processes and disturbed 5-HT homeostasis is implicated in a variety of psychiatric and addictive disorders. Here, we describe the functional characterization of the serotonin transporter (SERT) knockout rat model, that is generated by N-ethy
PMID 17467186

Dosing and scheduling influence the antitumor efficacy of a phosphinic peptide inhibitor of matrix metalloproteinases.

Dive V, Andarawewa KL, Boulay A, Matziari M, Beau F, Guerin E, Rousseau B, Yiotakis A, Rio MC.SourceCEA, Departement d'Ingenierie et d'Etudes des Proteines, Gif/Yvette, France. vincent.dive@cea.fr <vincent.dive@cea.fr>
International journal of cancer. Journal international du cancer.Int J Cancer.2005 Feb 20;113(5):775-81.
The in vivo disposition and antitumor efficacy of a newly developed phosphinic matrix metalloproteinase inhibitor (RXP03) were examined. RXP03 potently inhibits MMP-11, MMP-8 and MMP-13, but not MMP-1 and MMP-7. Twenty-four hours after i.p. injection into mice, most of the RXP03 was recovered intact
PMID 15499617

Patent 6,949,645 [ 56 ] Chemical Structures - Structures Starting