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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/10/24 16:10:08」(JST)
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Nisoldipine
|
|
Systematic (IUPAC) name |
isobutyl methyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
|
Clinical data |
Trade names |
Sular |
AHFS/Drugs.com |
Monograph |
MedlinePlus |
a696009 |
Pregnancy
category |
- US: C (Risk not ruled out)
|
Routes of
administration |
Oral |
Legal status |
Legal status |
|
Pharmacokinetic data |
Protein binding |
99% |
Biological half-life |
7-12 hours |
Identifiers |
CAS Number |
63675-72-9 Y |
ATC code |
C08CA07 (WHO) |
PubChem |
CID 4499 |
IUPHAR/BPS |
2524 |
DrugBank |
DB00401 N |
ChemSpider |
4343 N |
UNII |
4I8HAB65SZ N |
KEGG |
D00618 Y |
ChEBI |
CHEBI:7577 N |
ChEMBL |
CHEMBL1726 N |
Chemical data |
Formula |
C20H24N2O6 |
Molar mass |
388.414 g/mol |
NY (what is this?) (verify) |
Nisoldipine (INN) is a calcium channel blocker of the dihydropyridine class. It sold in the United States under the proprietary name Sular. Nisoldipine has tropism for cardiac blood vessels.[1]
External links
- Mielcarek J, Grobelny P, Szamburska O (2005). "The effect of beta-carotene on the photostability of nisoldipine.". Methods Find Exp Clin Pharmacol. 27 (3): 167–71. doi:10.1358/mf.2005.27.3.890873. PMID 15834448.
- Missan S, Zhabyeyev P, Dyachok O, Jones SE, McDonald TF (November 2003). "Block of cardiac delayed-rectifier and inward-rectifier K+ currents by nisoldipine". Br. J. Pharmacol. 140 (5): 863–70. doi:10.1038/sj.bjp.0705518. PMC 1574108. PMID 14530219.
- Hamilton S, Houle L, Thadani U (1999). "Rapid-release and coat-core formulations of nisoldipine in treatment of hypertension, angina, and heart failure.". Heart Dis. 1 (5): 279–88. PMID 11720635.
References
- ^ "Why is nisoldipine a specific agent in ischemic left ventricular dysfunction?". The American Journal of Cardiology. 75: E36–E40. doi:10.1016/S0002-9149(99)80446-9.
UpToDate Contents
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English Journal
- Evaluation of the chiral recognition properties and the column performances of three chiral stationary phases based on cellulose for the enantioseparation of six dihydropyridines by high-performance liquid chromatography.
- Yu J1, Tang J2, Yuan X1, Guo X1, Zhao L1.
- Chirality.Chirality.2017 Mar;29(3-4):147-154. doi: 10.1002/chir.22690. Epub 2017 Mar 28.
- PMID 28349560
- Polymeric behavior evaluation of PVP K30-poloxamer binary carrier for solid dispersed nisoldipine by experimental design.
- Kyaw Oo M1, Mandal UK1, Chatterjee B1.
- Pharmaceutical development and technology.Pharm Dev Technol.2017 Feb;22(1):2-12. doi: 10.3109/10837450.2015.1116568. Epub 2015 Nov 29.
- PMID 26616399
- The L-type Ca(2+) channel facilitates abnormal metabolic activity in the cTnI-G203S mouse model of hypertrophic cardiomyopathy.
- Viola H1, Johnstone V1, Cserne Szappanos H1, Richman T2, Tsoutsman T3,4, Filipovska A2, Semsarian C3,4,5, Hool L1,6.
- The Journal of physiology.J Physiol.2016 Jul 15;594(14):4051-70. doi: 10.1113/JP271681. Epub 2016 Jun 12.
- PMID 27062056
Japanese Journal
- Molecular Mechanism of the Urate-lowering Effects of Calcium Channel Blockers
- Simultaneous determination of m-nisoldipine and its three metabolites in rat plasma by liquid chromatography-mass spectrometry
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 878(29), 2989-2996, 2010-11-01
- NAID 10028043343
- nteractions between Grapefruit Juice and Calcium Channel Antagonists
Related Links
- Nisoldipine is a yellow crystalline substance, practically insoluble in water but soluble in ethanol. It has a molecular weight of 388.4. Pharmacodynamics Hemodynamic Effects Administration of a single dose of nisoldipine leads to ...
- Nisoldipine official prescribing information for healthcare professionals. Includes: indications, dosage, adverse reactions, pharmacology and more. ... Pharmacokinetics and Metabolism Nisoldipine pharmacokinetics are independent of ...
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