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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/26 16:47:15」(JST)

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Nifekalant (INN) is a class III antiarrhythmic agent approved in Japan for the treatment of arrhythmias and ventricular tachycardia.^[1] It has the brand name Shinbit.

References

^ Oyabe A, Sano H (February 2002). "[Pharmacological and clinical profile of nifekalant (shinbit injection), a class III antiarrhythmic drug]" (^{[dead link]} – ^{Scholar search}). Nippon Yakurigaku Zasshi (in Japanese) 119 (2): 103–9. doi:10.1254/fpj.119.103. PMID 11862758.

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1. QT短縮症候群 short qt syndrome

English Journal

Usefulness of ablation of complex fractionated atrial electrograms using nifekalant in persistent atrial fibrillation.

Kumagai K, Toyama H.SourceHeart Rhythm Center, Fukuoka Sanno Hospital, Fukuoka, Japan. Electronic address: kumagai@kouhoukai.or.jp.
Journal of cardiology.J Cardiol.2013 Jan;61(1):44-8. doi: 10.1016/j.jjcc.2012.08.015. Epub 2012 Oct 22.
BACKGROUND: Additional ablation of complex fractionated atrial electrograms (CFAE) after pulmonary vein isolation (PVI) has been shown to improve the success of ablation of persistent atrial fibrillation (AF). However, extensive ablation is often necessary to eliminate all CFAE or to terminate AF. W
PMID 23088936

Development of a reentrant arrhythmia model in human pluripotent stem cell-derived cardiac cell sheets.

Kadota S, Minami I, Morone N, Heuser JE, Agladze K, Nakatsuji N.SourceInstitute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University, iCeMS Research Building, Yoshida Honmachi, Sakyo-ku, Kyoto 606-8501, Japan.
European heart journal.Eur Heart J.2012 Nov 30. [Epub ahead of print]
AimsDevelopment of a human cell-derived reentrant arrhythmia model is needed for studying the mechanisms of disease and accurate drug response.Methods and resultsWe differentiated human pluripotent stem cells (hPSCs) into cardiomyocytes, and then re-plated them into cell sheets that proved capable o
PMID 23201623

Japanese Journal

Effects of pH on Nifekalant-Induced Electrophysiological Change Assessed in the Langendorff Heart Model of Guinea Pigs

Kazusa Katsuyuki,Nakamura Yuji,Watanabe Yudai [他]
Journal of pharmacological sciences 124(2), 153-159, 2014-02
NAID 40019992563

人工心肺離脱時の難治性心室頻拍（VT ストーム）に対しニフェカラントが著効した症例

松川志乃,石井久成,福田和彦
Cardiovascular Anesthesia 18(1), 25-28, 2014
心室頻拍（VT）を頻発する狭心症に対し緊急冠動脈バイパスならびに僧帽弁形成術を施行された症例の麻酔を経験した。アミオダロンを投与中であったが，人工心肺（CPB）離脱中に再度 VT となった。頻回の電気的除細動を行ったが回復せず，難治性心室頻拍（VT ストーム）となり，CPB 離脱困難となった。ニフェカラントの投与により，一時的に心静止しその後洞調律に復帰した。心房ペーシングを行い，安定した循環動 …
NAID 130004701455

Effects of pH on Nifekalant-Induced Electrophysiological Change Assessed in the Langendorff Heart Model of Guinea Pigs

Kazusa Katsuyuki,Nakamura Yuji,Watanabe Yudai,Ando Kentaro,Sugiyama Atsushi
Journal of Pharmacological Sciences 124(2), 153-159, 2014
… Since information regarding the effects of pH on the extent of nifekalant-induced repolarization delay and torsades de pointes remains limited, we assessed it with a Langendorff heart model of guinea pigs. …
NAID 130003391474

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★リンクテーブル★

リンク元	「ニフェカラント」
拡張検索	「nifekalant hydrochloride」

「ニフェカラント」

Nifekalant
Systematic (IUPAC) name
	6-[(2-{(2-hydroxyethyl)[3-(4-nitrophenyl)propyl]amino}ethyl)amino]-1,3-dimethylpyrimidine-2,4(1H,3H)-dione
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only
Routes	IV
Identifiers
CAS number	130636-43-0
ATC code	None
PubChem	CID 4486
UNII	5VZ7GZM43E
Chemical data
Formula	C19H27N5O5
Mol. mass	405.44 g/mol
	SMILES CN1C(=CC(=O)N(C1=O)C)NCCN(CCCC2=CC=C(C=C2)[N+](=O)[O-])CCO;
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