neurobeachin

English Journal

Neurobeachin Regulates Glutamate- and GABA-Receptor Targeting to Synapses via Distinct Pathways.

Farzana F1, Zalm R1, Chen N2, Li KW2, Grant SG3, Smit AB2, Toonen RF1, Verhage M4,5.
Molecular neurobiology.Mol Neurobiol.2016 May;53(4):2112-23. doi: 10.1007/s12035-015-9164-8. Epub 2015 May 2.
Neurotransmission and synaptic strength depend on expression of post-synaptic receptors on the cell surface. Post-translational modification of receptors, trafficking to the synapse through the secretory pathway, and subsequent insertion into the synapse involves interaction of the receptor with A-k
PMID 25934101

Nuclear Localization of the Autism Candidate Gene Neurobeachin and Functional Interaction with the NOTCH1 Intracellular Domain Indicate a Role in Regulating Transcription.

Tuand K1,2, Stijnen P1, Volders K1,2, Declercq J1, Nuytens K1,2, Meulemans S1, Creemers J1.
PloS one.PLoS One.2016 Mar 21;11(3):e0151954. doi: 10.1371/journal.pone.0151954. eCollection 2016.
BACKGROUND: Neurobeachin (NBEA) is an autism spectrum disorders (ASD) candidate gene. NBEA deficiency affects regulated secretion, receptor trafficking, synaptic architecture and protein kinase A (PKA)-mediated phosphorylation. NBEA is a large multidomain scaffolding protein. From N- to C-terminus,
PMID 26999814

Genome wide association study identifies variants in NBEA associated with migraine in bipolar disorder.

Jacobsen KK, Nievergelt CM, Zayats T, Greenwood TA, Anttila V, Akiskal HS; BiGS Consortium; IHG Consortium, Haavik J, Bernt Fasmer O, Kelsoe JR, Johansson S, Oedegaard KJ.
Journal of affective disorders.J Affect Disord.2015 Feb 1;172:453-61. doi: 10.1016/j.jad.2014.10.004. Epub 2014 Oct 12.
BACKGROUND: Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background of bipolar patients with and without migraine.METHODS: We performed a geno
PMID 25451450