びまん性膵ラ氏島細胞増殖症、膵島細胞増殖症
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/09/25 17:05:04」(JST)
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Nesidioblastosis |
Classification and external resources |
ICD-9 |
251.9 |
OMIM |
601820 256450 |
DiseasesDB |
8922 |
eMedicine |
ped/1565 |
MeSH |
D046768 |
Nesidioblastosis is a controversial medical term for hyperinsulinemic hypoglycemia attributed to excessive function of pancreatic beta cells with an abnormal microscopic appearance. The term was coined in the first half of the 20th century. The abnormal histologic aspects of the tissue included the presence of islet cell enlargement, islet cell dysplasia, beta cells budding from ductal epithelium, and islets in apposition to ducts.
By the 1970s, nesidioblastosis was primarily used to describe the pancreatic dysfunction associated with persistent congenital hyperinsulinism and in most cases from the 1970s until the 1980s, it was used as a synonym for what is now referred to as congenital hyperinsulinism. Most congenital hyperinsulinism is caused by different mechanisms than excessive proliferation of beta cells in a fetal pattern and the term fell into disfavor after it was recognized in the late 1980s that the characteristic tissue features were sometimes seen in pancreatic tissue from normal infants and even adults, and is not consistently associated with hyperinsulinemic hypoglycemia.
However, the term has been resurrected in recent years to describe a form of acquired hyperinsulinism with beta cell hyperplasia found in adults, especially after gastrointestinal surgery.[1][2][3] Evidence of physiologic mechanisms purporting that weight loss surgery conveys the ability to induce a more contemporary presentation of nesidioblastosis remains elusive and is of intense interest to diabetes researchers.
See also
- Congenital hyperinsulinism
- Neonatal hypoglycemia
References
- ^ Raffel A, Krausch M M, Anlauf M, Wieben D, Braunstein S, Klöppel G, Röher H, Knoefel W (2007). "Diffuse nesidioblastosis as a cause of hyperinsulinemic hypoglycemia in adults: a diagnostic and therapeutic challenge". Surgery 141 (2): 179–84; discussion 185–6. doi:10.1016/j.surg.2006.04.015. PMID 17263973.
- ^ Clancy T, Moore F, Zinner M (2006). "Post-gastric bypass hyperinsulinism with nesidioblastosis: subtotal or total pancreatectomy may be needed to prevent recurrent hypoglycemia". J Gastrointest Surg 10 (8): 1116–9. doi:10.1016/j.gassur.2006.04.008. PMID 16966030.
- ^ Raffel A, Anlauf M, Hosch S, Krausch M, Henopp T, Bauersfeld J, Klofat R, Bach D, Eisenberger C, Kloppel G, Knoefel W (2006). "Hyperinsulinemic hypoglycemia due to adult nesidioblastosis in insulin-dependent diabetes". World J Gastroenterol 12 (44): 7221–4. PMID 17131493.
External links
- Hyperinsulinemic Hypoglycemia with Nesidioblastosis after Gastric-Bypass Surgery
- Pancreatic nesidioblastosis in adults
- Nesidioblastosis
- I Used To Fear Death But Now It's Life That Scares Me...Part 8
UpToDate Contents
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English Journal
- Ghrelin and Obestatin in Human Neuroendocrine Tumors: Expression and Effect on Obestatin Levels after Food Intake.
- Grönberg M, Tsolakis AV, Holmbäck U, Stridsberg M, Grimelius L, Janson ET.SourceSection of Endocrine Oncology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
- Neuroendocrinology.Neuroendocrinology.2012 Dec 8. [Epub ahead of print]
- Background: Ghrelin and obestatin are derived from the same peptide hormone precursor and are mainly produced by the gastric mucosa. Ghrelin is involved in many biological processes, whereas the physiological function of obestatin needs further investigation. The aims of the present study were to es
- PMID 23147274
- Glucagon-like peptide-1 receptor imaging with [Lys(40)(Ahx-HYNIC- (99m)Tc/EDDA)NH (2)]-exendin-4 for the detection of insulinoma.
- Sowa-Staszczak A, Pach D, Mikołajczak R, Mäcke H, Jabrocka-Hybel A, Stefańska A, Tomaszuk M, Janota B, Gilis-Januszewska A, Małecki M, Kamiński G, Kowalska A, Kulig J, Matyja A, Osuch C, Hubalewska-Dydejczyk A.SourceDepartment of Endocrinology, Jagiellonian University Medical College, Kopernika 17, 31-501, Cracow, Poland, sowiana@gmail.com.
- European journal of nuclear medicine and molecular imaging.Eur J Nucl Med Mol Imaging.2012 Dec 7. [Epub ahead of print]
- PURPOSE: The objective of this article is to present a new method for the diagnosis of insulinoma with the use of [Lys(40)(Ahx-HYNIC-(99m)Tc/EDDA)NH(2)]-exendin-4.METHODS: Studies were performed in 11 patients with negative results of all available non-isotopic diagnostic methods (8 with symptoms of
- PMID 23224740
Japanese Journal
- Histopathology of Incidental Findings in Beagles Used in Toxicity Studies
- Sato Junko,Doi Takuya,Wako Yumi,Hamamura Masao,Kanno Takeshi,Tsuchitani Minoru,Narama Isao
- Journal of Toxicologic Pathology 25(1), 103-134, 2012
- … Nesidioblastosis is seen rarely in the pancreas of beagles. …
- NAID 130001884591
- インスリノーマとの鑑別が困難であった膵島細胞症の1例
- 中山 雄介,大江 秀明,松林 潤,余語 覚匡,鬼頭 祥悟,花本 浩一,北口 和彦,浦 克明,平良 薫,吉川 明,石上 俊一,田村 淳,白瀬 智之,土井 隆一郎
- 膵臓 = The Journal of Japan Pancreas Society 26(5), 613-618, 2011-10-25
- NAID 10030473953
Related Links
- 膵島細胞症(nesidioblastosis)はインスリン過剰症の中の一つであり、低血糖を伴う 乳幼児に見られる膵臓の形態異常とされ、発生 ... 膵島細胞症(nesidioblastosis)は膵 内分泌細胞、主としてB細胞のび慢性異常増殖を示す疾患であり、膵外分泌領域周辺に ...
- Nesidioblastosis is a controversial medical term for hyperinsulinemic hypoglycemia attributed to excessive function of pancreatic beta cells with an abnormal microscopic appearance. The term was coined in the first half of the 20th century.
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