| Neonatal sepsis |
| Classification and external resources |
| Specialty |
pediatrics |
| ICD-10 |
P36 |
| ICD-9-CM |
771.81 |
| MedlinePlus |
007303 |
| eMedicine |
article/978352 |
Neonatal sepsis specifically refers to the presence in a newborn baby of a bacterial blood stream infection (BSI) (such as meningitis, pneumonia, pyelonephritis, or gastroenteritis) in the setting of fever. Older textbooks may refer to neonatal sepsis as "sepsis neonatorum". Criteria with regards to hemodynamic compromise or respiratory failure are not useful clinically because these symptoms often do not arise in neonates until death is imminent and unpreventable. Neonatal sepsis is divided into two categories: early-onset sepsis (EOS) and late-onset sepsis (LOS). EOS refers to sepsis presenting in the first 7 days of life (although some refer to EOS as within the first 72 hours of life), with LOS referring to presentation of sepsis after 7 days (or 72 hours, depending on the system used). neonatal sepsis is the single most important cause of neonatal death in hospital as well as community in developing country.
It is difficult to clinically exclude sepsis in newborns less than 90 days old that have fever (defined as a temperature > 38°C (100.4°F). Except in the case of obvious acute viral bronchiolitis, the current practice in newborns less than 30 days old is to perform a complete workup including complete blood count with differential, blood culture, urinalysis, urine culture, and cerebrospinal fluid (CSF) studies and CSF culture, admit the newborn to the hospital, and treat empirically for serious bacterial infection for at least 48 hours until cultures are demonstrated to show no growth. Attempts have been made to see whether it is possible to risk stratify newborns in order to decide if a newborn can be safely monitored at home without treatment despite having a fever. One such attempt is the Rochester criteria.
Contents
- 1 Signs and symptoms
- 2 Risk factors
- 3 Diagnosis
- 4 Treatment
- 5 References
Signs and symptoms
The signs of sepsis are non-specific and include:[1]
- Body temperature changes
- Breathing problems
- Diarrhea
- Low blood sugar
- Reduced movements
- Reduced sucking
- Seizures
- Bradycardia
- Swollen belly area
- Vomiting
- Yellow skin and whites of the eyes (jaundice)
A heart rate above 160 can also be an indicator of sepsis, this tachycardia can present up to 24 hours before the onset of other signs.
Risk factors
A study performed at Strong Memorial Hospital in Rochester, New York, showed that infants ≤ 60 days old meeting the following criteria were at low-risk for having a serious bacterial illness:[2]
- generally well-appearing
- previously healthy
- full term (at ≥37 weeks gestation)
- no antibiotics perinatally
- no unexplained hyperbilirubinemia that required treatment
- no antibiotics since discharge
- no hospitalizations
- no chronic illness
- discharged at the same time or before the mother
- no evidence of skin, soft tissue, bone, joint, or ear infection
- WBC count 5,000-15,000/mm3
- absolute band count ≤ 1,500/mm3
- urine WBC count ≤ 10 per high power field (hpf)
- stool WBC count ≤ 5 per high power field (hpf) only in infants with diarrhea
Those meeting these criteria likely do not require a lumbar puncture, and are felt to be safe for discharge home without antibiotic treatment, or with a single dose of intramuscular antibiotics, but will still require close outpatient follow-up.
One risk for Group B streptococcal infection (GBS) is Preterm rupture of membranes. Screening women for GBS (via vaginal and rectal swabbing) and treating culture positive women with intrapartum chemoprophylaxis is reducing the number of neonatal sepsis caused by GBS.
Diagnosis
Neonatal sepsis screening:
- DLC (differential leukocyte count) showing increased numbers of polymorphs.
- DLC: band cells > 20%.
- increased haptoglobins.
- micro ESR (Erythrocyte Sedimentation Rate) titer > 55mm.
- gastric aspirate showing > 5 polymorphs per high power field.
- newborn CSF (Cerebrospinal fluid) screen: showing increased cells and proteins.
- suggestive history of chorioamnionitis, PROM (Premature rupture of membranes), etc...
Culturing for microorganisms from a sample of CSF, blood or urine, is the gold standard test for definitive diagnosis of neonatal sepsis. This can give false negatives due to the low sensitivity of culture methods and because of concomitant antibiotic therapy. Lumbar punctures should be done when possible as 10-15% presenting with sepsis also have meningitis, which warrants an antibiotic with a high CSF penetration.[citation needed]
CRP is not very accurate in picking up cases.[3]
Treatment
Note that, in neonates, sepsis is difficult to diagnose clinically. They may be relatively asymptomatic until hemodynamic and respiratory collapse is imminent, so, if there is even a remote suspicion of sepsis, they are frequently treated with antibiotics empirically until cultures are sufficiently proven to be negative. In addition to fluid resuscitation and supportive care, a common antibiotic regimen in infants with suspected sepsis is a beta-lactam antibiotic (usually ampicillin) in combination with an aminoglycoside (usually gentamicin) or a third-generation cephalosporin (usually cefotaxime—ceftriaxone is generally avoided in neonates due to the theoretical risk of kernicterus.) The organisms which are targeted are species that predominate in the female genitourinary tract and to which neonates are especially vulnerable to, specifically Group B Streptococcus, Escherichia coli, and Listeria monocytogenes (This is the main rationale for using ampicillin versus other beta-lactams.) Of course, neonates are also vulnerable to other common pathogens that can cause meningitis and bacteremia such as Streptococcus pneumoniae and Neisseria meningitidis. Although uncommon, if anaerobic species are suspected (such as in cases where necrotizing enterocolitis or intestinal perforation is a concern, clindamycin is often added.
Granulocyte-macrophage colony stimulating factor (GM-CSF) is sometimes used in neonatal sepsis. However, a 2009 study found that GM-CSF corrects neutropenia if present but it has no effect on reducing sepsis or improving survival.[4]
References
- ^ pmhdev. "Updating PubMed Health". PubMed Health.
- ^ Dagan R, Powell KR, Hall CB, Menegus MA (Dec 1985). "Identification of infants unlikely to have serious bacterial infection although hospitalized for suspected sepsis". J. Pediatr. 107 (6): 855–60. doi:10.1016/S0022-3476(85)80175-X. PMID 4067741.
- ^ Delanghe, JR; Speeckaert, MM (4 February 2015). "Translational research and biomarkers in neonatal sepsis.". Clinica chimica acta; international journal of clinical chemistry. PMID 25661089.
- ^ Carr R, Brocklehurst P, Doré CJ, Modi N (January 2009). "Granulocyte-macrophage colony stimulating factor administered as prophylaxis for reduction of sepsis in extremely preterm, small for gestational age neonates (the PROGRAMS trial): a single-blind, multicentre, randomised controlled trial". Lancet 373 (9659): 226–33. doi:10.1016/S0140-6736(09)60071-4. PMID 19150703.
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Certain conditions originating in the perinatal period / fetal disease (P, 760–779)
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Maternal factors and
complications of pregnancy,
labour and delivery |
| placenta: |
- Placenta praevia
- Placental insufficiency
- Twin-to-twin transfusion syndrome
|
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| chorion/amnion: |
|
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| umbilical cord: |
- Umbilical cord prolapse
- Nuchal cord
- Single umbilical artery
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Length of gestation
and fetal growth |
- Small for gestational age/Large for gestational age
- Preterm birth/Postmature birth
- Intrauterine growth restriction
|
|
| Birth trauma |
- scalp
- Cephalhematoma
- Chignon
- Caput succedaneum
- Subgaleal hemorrhage
- Brachial plexus lesion
- Erb's palsy
- Klumpke paralysis
|
|
| By system |
| Respiratory |
- Intrauterine hypoxia
- Infant respiratory distress syndrome
- Transient tachypnea of the newborn
- Meconium aspiration syndrome
- pleural disease
- Pneumothorax
- Pneumomediastinum
- Wilson–Mikity syndrome
- Bronchopulmonary dysplasia
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| Cardiovascular |
- Pneumopericardium
- Persistent fetal circulation
|
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Haemorrhagic and
hematologic disease |
- Vitamin K deficiency
- Haemorrhagic disease of the newborn
- HDN
- ABO
- Anti-Kell
- Rh c
- Rh D
- Rh E
- Hydrops fetalis
- Hyperbilirubinemia
- Kernicterus
- Neonatal jaundice
- Velamentous cord insertion
- Intraventricular hemorrhage
- Germinal matrix hemorrhage
- Anemia of prematurity
|
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| Digestive |
- Ileus
- Necrotizing enterocolitis
- Meconium peritonitis
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Integument and
thermoregulation |
- Erythema toxicum
- Sclerema neonatorum
|
|
| Nervous system |
- Periventricular leukomalacia
|
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| Musculoskeletal |
- Gray baby syndrome
- muscle tone
- Congenital hypertonia
- Congenital hypotonia
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| Infectious |
- Vertically transmitted infection
- Congenital rubella syndrome
- Neonatal herpes simplex
- Mycoplasma hominis infection
- Omphalitis
- Neonatal sepsis
- Group B streptococcal infection
- Neonatal conjunctivitis
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| Other |
- Perinatal mortality
- Stillbirth
- Infant mortality
- Neonatal withdrawal
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Index of developmental medicine
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| Description |
- Embryology
- Cell lines
- Stem cells
- endoderm
- mesoderm
- ectoderm
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| Disease |
- Due to toxins
- Syndromes
- Chromosomal
- Neonate
- Twins
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Index of obstetrics
|
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| Description |
- Pregnancy
- Development
- Anatomy
|
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| Disease |
- Pregnancy and childbirth
- Placenta and neonate
- Infections
- Symptoms and signs
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| Treatment |
- Procedures
- Drugs
- oxytocins
- labor repressants
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Vertically transmitted infections (P35–P39, 771)
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| Gestational |
- Viruses
- Congenital rubella syndrome
- Congenital cytomegalovirus infection
- Neonatal herpes simplex
- Hepatitis B
- Congenital varicella syndrome
- HIV
- Fifth disease
- Bacteria
- Other
- transplacental
- TORCH complex
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| During birth |
- transcervical
- Candidiasis
- Gonorrhea
- Listeriosis
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| Late pregnancy |
- Listeriosis
- Congenital cytomegalovirus infection
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| By breastfeeding |
- Breastfeeding
- Tuberculosis
- HIV
|
|
|
Index of obstetrics
|
|
| Description |
- Pregnancy
- Development
- Anatomy
|
|
| Disease |
- Pregnancy and childbirth
- Placenta and neonate
- Infections
- Symptoms and signs
|
|
| Treatment |
- Procedures
- Drugs
- oxytocins
- labor repressants
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