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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/25 23:53:15」(JST)

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Neoendorphins are a class of naturally occurring opioid peptides derived from the proteolytic cleavage of prodynorphin.^[1] They include α-neoendorphin and β-neoendorphin.

References[edit]

^ Seizinger BR, Grimm C, Höllt V, Herz A (February 1984). "Evidence for a selective processing of proenkephalin B into different opioid peptide forms in particular regions of rat brain and pituitary". Journal of Neurochemistry 42 (2): 447–57. PMID 6141221.

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English Journal

Spinal astrocytes produce and secrete dynorphin neuropeptides.

Wahlert A, Funkelstein L, Fitzsimmons B, Yaksh T, Hook V.SourceSkaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA, USA.
Neuropeptides.Neuropeptides.2013 Apr;47(2):109-15. doi: 10.1016/j.npep.2012.10.006. Epub 2013 Jan 3.
Dynorphin peptide neurotransmitters (neuropeptides) have been implicated in spinal pain processing based on the observations that intrathecal delivery of dynorphin results in proalgesic effects and disruption of extracellular dynorphin activity (by antisera) prevents injury evoked hyperalgesia. Howe
PMID 23290538

Neuropeptide alterations in the tree shrew hypothalamus during volatile anesthesia.

Fouillen L, Petruzziello F, Veit J, Bhattacharyya A, Kretz R, Rainer G, Zhang X.SourceVisual Cognition Laboratory, Department of Medicine, University of Fribourg, Chemin du Musée 5, Fribourg, CH-1700, Switzerland.
Journal of proteomics.J Proteomics.2013 Mar 27;80:311-9. doi: 10.1016/j.jprot.2012.11.002. Epub 2012 Dec 8.
Neuropeptides are critical signaling molecules, involved in the regulation of diverse physiological processes including energy metabolism, pain perception and brain cognitive state. Prolonged general anesthesia has an impact on many of these processes, but the regulation of peptides by general anest
PMID 23228960

Acute cocaine treatment increases thimet oligopeptidase in the striatum of rat brain.

Dalio FM, Visniauskas B, Bicocchi ES, Perry JC, Freua R, Gesteira TF, Nader HB, Machado MF, Tufik S, Ferro ES, Andersen ML, Toledo CA, Chagas JR, Oliveira V.SourceDepartamento de Biofísica, Universidade Federal de São Paulo, SP, Brazil.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2012 Mar 23;419(4):724-7. doi: 10.1016/j.bbrc.2012.02.088. Epub 2012 Feb 24.
Many studies indicate that thimet oligopeptidase (EC3.4.24.15; TOP) can be implicated in the metabolism of bioactive peptides, including dynorphin 1-8, α-neoendorphin, β-neoendorphin and GnRH. Furthermore, the higher levels of this peptidase are found in neuroendocrine tissue and testis. In the pr
PMID 22387539

Japanese Journal

中枢移行性アンジオテンシン変換酵素阻害剤投与によるラット脳内ペプチド性物質のプロファイリング

金澤佐知子,細井一広,照井一史,下山律子,中川潤一,板垣史郎,早狩誠
弘前医学 65(1), 95-103, 2014-04-15
… 量数3,000以下であった．なお，これらの質量数はすべて一価イオンとして検出されたことから，すべて物質固有の質量数を反映していた．検出した質量数は，ACE が分解する脳内ペプチド（LH-RH,substance P, β-neoendorphin, neuromedin B, LVV-hemorphin-7, amyloid β-protein）やinsulin-regulated aminopeptidase（IRAP）の基質と考えられているvasopressin とは異なる値を示した．脳内にはACE やIRAP 以外にも活性中心にZn2+を有するメタロプロテアーゼが …
NAID 120005429846

Substrate specificity of carp hepatopancreatic cathepsin S for peptides and myofibrillar proteins.

, , , , ,
Fisheries science 66(6), 1138-1143, 2000
… The bond specificity of cathepsin S for α-neoendorphin and neurotensin was 6Arg-7Lys and 3Tyr-4Glu, respectively. …
NAID 130003903546

Substrate Specificity of Rabbit Liver Metalloendopeptidase and Its New Fluorogenic Peptide Substrates.

, , , ,
The Journal of Biochemistry 118(4), 855-861, 1995
… MEP degraded oligopeptides, including bradykinin, α-neoendorphin, bovine adrenal medulla dodecapeptide, substance P, bombesin, neurotensin, and α-endorphin, but not polypeptides such as reduced lysozyme and histone H4, hence, MEP probably belongs to the family of endo-oligopeptidases. …
NAID 130003532679