針生検

関: aspiration biopsy

WordNet

have or feel a need for; "always needing friends and money"
a condition requiring relief; "she satisfied his need for affection"; "God has no need of men to accomplish His work"; "there is a demand for jobs" (同)demand
anything that is necessary but lacking; "he had sufficient means to meet his simple needs"; "I tried to supply his wants" (同)want
prick with a needle
a sharp pointed implement (usually steel)
a slender pointer for indicating the reading on the scale of a measuring instrument
goad or provoke,as by constant criticism; "He needled her with his sarcastic remarks" (同)goad
examination of tissues or liquids from the living body to determine the existence or cause of a disease
of trees whose leaves are acerate

PrepTutorEJDIC

〈U〉《時にa~》『必要』,入用 / 〈C〉《しばしば複数形で》『必要なもの』,(…の)必要品《+『for』+『名』》 / 〈C〉(…に対する)欲求,切望《+『for』+『名』》 / 〈U〉(…の)『困窮』,欠乏,不足《+『of』(『for』)+『名』》 / 〈U〉『困った時』(『事態』),まさかの時 / …‘を'必要とする,要する / 《疑問文・否定文,また疑問・否定の内容を表す文で》…『する必要がある』,しなければならない / 《need not have doneの形で》…する必要はなかったのに
『針』,縫い針;(編物用の)かぎ針,編み棒 / (レコードプレーヤーの)針;(磁石・らしん盤など各種計器の)針 / 外科用の針(縫合針など);注射針 / 針状のもの;小尖塔(しょうせんとう);とがった山頂 / (マツ・モミなどの)針葉 / …‘を'針で縫う(編む);…‘に'針を通す / (…のことで)〈人〉‘をいじめる,脳ます《+『名』+『about』+『名』(do『ing』)》;〈人〉‘を'いじめて(…)させる《『名』+『into』do『ing』》 / 縫い物(編物)をする

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/18 15:36:33」(JST)

wiki en

[Wiki en表示]

Fine-needle aspiration biopsy (FNAB, FNA or NAB), or fine-needle aspiration cytology (FNAC), is a diagnostic procedure used to investigate lumps or masses. In this technique, a thin, hollow needle is inserted into the mass for sampling of cells that, after being stained, will be examined under a microscope. There could be cytology exam of aspirate (cell specimen evaluation, FNAC) or histological (biopsy - tissue specimen evaluation, FNAB).^[1] Fine-needle aspiration biopsies are very safe, minor surgical procedures. Often, a major surgical (excisional or open) biopsy can be avoided by performing a needle aspiration biopsy instead. In 1981, the first fine-needle aspiration biopsy in the United States was done at Maimonides Medical Center,^[2] eliminating the need for surgery and hospitalization. Today, this procedure is widely used in the diagnosis of cancer and inflammatory conditions.

A needle aspiration biopsy is safer and less traumatic than an open surgical biopsy, and significant complications are usually rare, depending on the body site. Common complications include bruising and soreness. There is a risk, because the biopsy is very small (only a few cells), that the problematic cells will be missed, resulting in a false negative result. There is also a risk that the cells taken will not enable a definitive diagnosis.

Applications

This type of sampling is performed for one of two reasons:

A biopsy is performed on a lump or a tissue mass when its nature is in question.
For known tumors, this biopsy is performed to assess the effect of treatment or to obtain tissue for special studies.

When the lump can be felt, the biopsy is usually performed by a cytopathologist or a surgeon. In this case, the procedure is usually short and simple. Otherwise, it may be performed by an interventional radiologist, a doctor with training in performing such biopsies under x-ray or ultrasound guidance. In this case, the procedure may require more extensive preparation and take more time to perform.

Also, fine-needle aspiration is the main method used for chorionic villus sampling,^[3] as well as for many types of body fluid sampling.

It is also used for ultrasound-guided aspiration of breast abscess,^[4] of breast cysts, and of seromas.^[5]

Preparation

Several preparations may be necessary before this procedure.

No use of aspirin or non-steroidal anti-inflammatory medications (e.g. ibuprofen, naproxen) for one week before the procedure;
No food intake a few hours before the procedure;
Routine blood tests (including clotting profile) must be completed two weeks before the biopsy;
Suspension of blood anticoagulant medications;
Antibiotic prophylaxis may be instituted.

Before the procedure is started, vital signs (pulse, blood pressure, temperature, etc.) may be taken. Then, depending on the nature of the biopsy, an intravenous line may be placed. Very anxious patients may want to be given sedation through this line. For patients with less anxiety, oral medication (Valium) can be prescribed to be taken before the procedure.

Procedure

A physician's hands are seen performing a needle biopsy to determine nature of lump either fluid-filled cyst or solid tumor.

The skin above the area to be biopsied is swabbed with an antiseptic solution and draped with sterile surgical towels. The skin, underlying fat, and muscle may be numbed with a local anesthetic, although this is often not necessary with superficial masses. After locating the mass for biopsy, using x-rays or palpation, a special needle of very fine diameter is passed into the mass. The needle may be inserted and withdrawn several times. There are many reasons for this:

One needle may be used as a guide, with the other needles placed along it to achieve a more precise position.
Sometimes, several passes may be needed to obtain enough cells for the intricate tests which the cytopathologists perform.

After the needles are placed into the mass, cells are withdrawn by aspiration with a syringe and spread on a glass slide. The patient's vital signs are taken again, and the patient is removed to an observation area for about 3 to 5 hours.

For biopsies in the breast, ultrasound-guided fine needle biopsy is the most common.

Post-operative care and complications

FNA of pancreatic tissue. An adenocarcinoma is seen on the left, normal ductal epithelium on the right.

As with any surgical procedure, complications are possible, but major complications due to thin needle aspiration biopsies are fairly uncommon, and when complications do occur, they are generally mild. The kind and severity of complications depend on the organs from which a biopsy is taken or the organs gone through to obtain cells.

After the procedure, mild analgesics are used to control post-operative pain. Aspirin or aspirin substitutes should not be taken for 48 hours after the procedure (unless aspirin is prescribed for a cardiac or neurological condition). Since sterility is maintained throughout the procedure, infection is rare. But should an infection occur, it will be treated with antibiotics. Bleeding is the most common complication of this procedure. A slight bruise may also appear. If a lung or kidney biopsy has been performed, it is very common to see a small amount of blood in sputum or urine after the procedure. Only a small amount of bleeding should occur. During the observation period after the procedure, bleeding should decrease over time. If more bleeding occurs, this will be monitored until it subsides. Rarely, major surgery will be necessary to stop the bleeding.

Other complications depend upon the body part on which the biopsy takes place:

Lung biopsies are frequently complicated by pneumothorax (collapsed lung). This complication can also accompany biopsies in the upper abdomen near the base of the lung. About one-quarter to one-half of patients having lung biopsies will develop pneumothorax. Usually, the degree of collapse is small and resolves on its own without treatment. A small percentage of patients will develop a pneumothorax serious enough to require hospitalization and placement of a chest tube for treatment. Although it is impossible to predict in whom this will occur, collapsed lungs are more frequent and more serious in patients with severe emphysema and in patients in whom the biopsy is difficult to perform.
For biopsies of the liver, bile leakages may occur, but these are quite rare.
Pancreatitis (inflammation of the pancreas) may occur after biopsies in the area around the pancreas.
In biopsies in the area of the breast, bleeding and bruising may occur, less frequently also infection (rarely) or (very rarely, and only if performed near the chest wall) pneumothorax.
Deaths have been reported from needle aspiration biopsies, but such outcomes are extremely rare.

Criticism

A recent study showed that in one case a needle biopsy of a liver tumor resulted in spread of the cancer along the path of the needle, and concluded that needle aspiration was dangerous and unnecessary. The conclusions drawn from this paper were strongly criticized subsequently.^[6]

References

^ http://www.indepreviews.com/article/2011/vol-13-no-1/006-084-FINE-NEEDLE-ASPIRATION-CYTOLOGY-%28F-N-A-C%29.pdf
^ http://www.maimonidesmed.org/Main/CultureofInnovation.aspx, First US Procedure
^ Chorionic villus sampling and amniocentesis: information for you from Royal College of Obstetricians and Gynaecologists. Date published: 01/06/2006
^ Trop I, Dugas A, David J, El Khoury M, Boileau JF, Larouche N, Lalonde L (October 2011). "Breast abscesses: evidence-based algorithms for diagnosis, management, and follow-up". Radiographics : a Review Publication of the Radiological Society of North America, Inc (review). 31 (6): 1683–99. doi:10.1148/rg.316115521. PMID 21997989.
^ Department of Pathology University of Massachusetts Medical School (Emeritus) Guido Majno Professor; Department of Pathology University of Massachusetts Medical School (Emerita) Isabelle Joris Associate Professor (12 August 2004). Cells, Tissues, and Disease : Principles of General Pathology: Principles of General Pathology. Oxford University Press. p. 435. ISBN 978-0-19-974892-1.
^ "bmj.com". Retrieved 2010-03-14.

Originally adapted from Preparing for a needle aspiration biopsy (634 KB). Public domain text of the National Institutes of Health Warren Magnuson Grant Clinical Center.
Video showing ultrasound-guided fine needle biopsy

External links

Aspiration Biopsy, Fine-Needle at the US National Library of Medicine Medical Subject Headings (MeSH)

Breast

-462749619 at GPnotebook - "fine needle aspiration cytology (breast)"

Lung

MedlinePlus Encyclopedia 003860 - "Lung needle biopsy"

Neck

ent/561 at eMedicine - "Fine-Needle Aspiration of Neck Masses"
MedlinePlus Encyclopedia 003899 - "Thyroid nodule fine needle aspirate"

Bone

MedlinePlus Encyclopedia 003658 - "Bone marrow aspiration"
med/2971 at eMedicine - "Bone Marrow Aspiration and Biopsy"

Risk

Risk of tumor cell seeding through biopsy and aspiration cytology 2014

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 乳房生検 breast biopsy
2. 超音波内視鏡ガイド下での tru-cut針を使用した生検 endoscopic ultrasound guided trucut biopsy
3. 甲状腺生検 thyroid biopsy
4. 胸腺神経内分泌（カルチノイド）腫瘍 thymic neuroendocrine carcinoid tumors
5. 先天性代謝異常：個々の障害の発見 inborn errors of metabolism identifying the specific disorder

English Journal

Accuracy and complications of CT-guided core needle biopsy of peripheral nerve sheath tumours.

Pianta M1, Chock E, Schlicht S, McCombe D.
Skeletal radiology.Skeletal Radiol.2015 Oct;44(9):1341-9. doi: 10.1007/s00256-015-2185-6. Epub 2015 Jun 16.
OBJECTIVE: This single-centre study retrospectively reviews the complications in patients that have occurred following peripheral nerve sheath tumour biopsy, and assesses whether there is an association with biopsy technique or underlying lesion characteristics.MATERIALS AND METHODS: 41 consecutive
PMID 26078215

Vacuum-assisted breast biopsy with 7-gauge, 8-gauge, 9-gauge, 10-gauge, and 11-gauge needles: how many specimens are necessary?

Preibsch H1, Baur A2, Wietek BM2, Krämer B3, Staebler A4, Claussen CD2, Siegmann-Luz KC2.
Acta radiologica (Stockholm, Sweden : 1987).Acta Radiol.2015 Sep;56(9):1078-84. doi: 10.1177/0284185114549224. Epub 2014 Sep 17.
BACKGROUND: Published national and international guidelines and consensus meetings on the use of vacuum-assisted biopsy (VAB) give different recommendations regarding the required numbers of tissue specimens depending on needle size and imaging method.PURPOSE: To evaluate the weights of specimens ob
PMID 25232187

The ultrasonography features of hyalinizing trabecular tumor of the thyroid gland and the role of fine needle aspiration cytology and core needle biopsy in its diagnosis.

Choi WJ1, Baek JH2, Ha EJ3, Choi YJ1, Hong MJ1, Song DE4, Sung JY5, Yoo H6, Jung SL7, Lee HY8, Lee JH1.
Acta radiologica (Stockholm, Sweden : 1987).Acta Radiol.2015 Sep;56(9):1113-8. doi: 10.1177/0284185114549225. Epub 2014 Sep 17.
BACKGROUND: Hyalinizing trabecular tumor (HTT) of the thyroid gland is a rare, benign neoplasm of follicular cell origin. Misdiagnosis of HTT as either papillary or medullary thyroid carcinoma after fine-needle aspiration (FNA) may lead to unnecessary surgery.PURPOSE: To evaluate the ultrasonography
PMID 25232186

Japanese Journal

Ectopic Cervical Thymoma:A Case Report with <sup>18</sup>F-fluorodeoxyglucose Positron Emission Tomography Findings

Shien Kazuhiko,Shien Tadahiko,Soh Junichi,Ikeda Hirokuni,Nogami Tomohiro,Taira Naruto,Doihara Hiroyoshi,Miyoshi Shinichiro
Acta Medica Okayama 66(4), 357-361, 2012-08
… A preoperative needle biopsy of the mass did not yield a definitive diagnosis. …
NAID 120004622485

精嚢腺癌と鑑別を要した嚢胞形成を伴うPSA低値前立腺癌の1例

伊丹祥隆,永井康晴,小林泰之 [他]
泌尿器科紀要 58(7), 349-353, 2012-07
… Transperineal needle biopsy of the prostate and cystic tumor of the seminal vesicle revealed adenocarcinoma of the prostate and seminal vesicle, but immunostaining for PSA was negative, so we diagnosed the case as primary adenocarcinoma of the seminal vesicle. …
NAID 40019362542

Related Pictures

★リンクテーブル★

リンク元	「生検」「aspiration biopsy」「針生検」
関連記事	「need」「needle」「needling」

「生検」

Fine-needle aspiration
	Diagnostics
	Micrograph of a needle aspiration biopsy specimen of a salivary gland showing adenoid cystic carcinoma. Pap stain.
MeSH	D044963
	[edit on Wikidata]

　　[★]

英: biopsy
同: バイオプシー、診査切除術 exploratory excision、試験切除術
関

管腔臓器に対しては内視鏡を用いて鉗子で病変を採取

針生検 needle biopsy

体内臓器を穿刺する。肝、腎、前立腺

ストリップバイオプシー strip biopsy

施行

前立腺癌

条件付き

リンパ節腫脹：感染によるリンパ節腫脹は自然消退しうるので一ヶ月以上経過観察してから。

禁忌

悪性黒色腫：転移しやすいため
精巣腫瘍：血行転移のおそれ　　　→　　ゆえに精巣腫瘍を否定できない陰嚢腫脹に対しては診断を兼ねた高位精巣摘除が標準的治療

「aspiration biopsy」

　　[★]

吸引生検、吸引細胞診

関: needle biopsy

「針生検」

　　[★]

英: needle biopsy
関: 吸引生検、生検

「need」

　　[★]

助詞(否定・疑問文で)

(英正式)～する必要がある
[need not have done](主に英)～する必要はなかったのに(実際にはした)
(英正式)[need not do]必ずしも～でない

furthermore, aneurysms need not always be present, and angiographic findings may be limited to stenotic segments and obliteration of vessels.(HIM.2125)(さらに、動脈瘤はいつも存在するわけでないし、血管造影所見は血管の狭窄や閉塞に限られるかもしれない。)

vt.
vi.
n.

関: ask for, call, claim, demand, desire, entail, essential, fundamental, necessary, necessitate, necessity, order, prerequisite, request, require, requirement

「needle」

　　[★]

n.

針、ニードル、針状晶、針葉

関: needle crystal

「needling」

　　[★]

穿刺

関: paracentesis、prick、pricking、puncture、stab

[1] ttp://www.indepreviews.com/article/2011/vol-13-no-1/006-084-FINE-NEEDLE-ASPIRATION-CYTOLOGY-%28F-N-A-C%29.pdf

[2] ttp://www.maimonidesmed.org/Main/CultureofInnovation.aspx, First US Procedure

[3] Chorionic villus sampling and amniocentesis: information for you from Royal College of Obstetricians and Gynaecologists. Date published: 01/06/2006

[trop-etal-2013-4] Trop I, Dugas A, David J, El Khoury M, Boileau JF, Larouche N, Lalonde L (October 2011). "Breast abscesses: evidence-based algorithms for diagnosis, management, and follow-up". Radiographics : a Review Publication of the Radiological Society of North America, Inc (review). 31 (6): 1683–99. doi:10.1148/rg.316115521. PMID 21997989.

[5] Department of Pathology University of Massachusetts Medical School (Emeritus) Guido Majno Professor; Department of Pathology University of Massachusetts Medical School (Emerita) Isabelle Joris Associate Professor (12 August 2004). Cells, Tissues, and Disease : Principles of General Pathology: Principles of General Pathology. Oxford University Press. p. 435. ISBN 978-0-19-974892-1.

[6] "bmj.com". Retrieved 2010-03-14.

v t e Operations/surgeries and other procedures of the breast (ICD-9-CM V3 85, ICD-10-PCS 0H)

Breast surgery	Breast-conserving surgery Lumpectomy Mastectomy Radical mastectomy Mammoplasty Breast implant Breast reduction plasty SPAIR Mastopexy Breast reconstruction Breast biopsy Fine-needle aspiration Interventions on the Lactiferous ducts Ductal lavage Ductoscopy Microdochectomy Central duct excision

Breast imaging	Mammography Positron emission mammography Tomosynthesis Xeromammography Galactography Breast MRI Breast ultrasound Automated whole-breast ultrasound Scintimammography Tactile imaging

Other	Breast cancer screening Breast self-examination

匿名

検索

案内

案内

needle biopsy