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- 関
WordNet
- of or relating to or designating narcotics; "narcotic addicts"; "narcotic stupor"
- a drug that produces numbness or stupor; often taken for pleasure or to reduce pain; extensive use can lead to addiction
- inducing stupor or narcosis; "narcotic drugs" (同)narcotizing, narcotising
- inducing mental lethargy; "a narcotic speech" (同)soporiferous, soporific
- a drug that neutralizes or counteracts the effects of another drug
- a muscle that relaxes while another contracts; "when bending the elbow the triceps are the antagonist"
- absence of the sense of pain without loss of consciousness
PrepTutorEJDIC
- 麻酔性の / 《名詞の前にのみ用いて》麻薬の / 麻酔剤,麻薬
- 対立する人,敵対者,競争相手(opponent)
- 無痛覚[症]
UpToDate Contents
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English Journal
- The mu opioid receptor: A new target for cancer therapy?
- Singleton PA1,2, Moss J2, Karp DD3,4, Atkins JT3, Janku F3.
- Cancer.Cancer.2015 Aug 15;121(16):2681-8. doi: 10.1002/cncr.29460. Epub 2015 Jun 4.
- Mu opioids are among the most widely used drugs for patients with cancer with both acute and chronic pain as well as in the perioperative period. Several retrospective studies have suggested that opioid use might promote tumor progression and as a result negatively impact survival in patients with a
- PMID 26043235
- Mediation of opioid analgesia by a truncated 6-transmembrane GPCR.
- Lu Z, Xu J, Rossi GC, Majumdar S, Pasternak GW, Pan YX.
- The Journal of clinical investigation.J Clin Invest.2015 Jul 1;125(7):2626-30. doi: 10.1172/JCI81070. Epub 2015 May 26.
- The generation of potent opioid analgesics that lack the side effects of traditional opioids may be possible by targeting truncated splice variants of the μ-opioid receptor. μ-Opioids act through GPCRs that are generated from the Oprm1 gene, which undergoes extensive alternative splicing. The most
- PMID 26011641
- Structure-Activity Relationships of (+)-Naltrexone-Inspired Toll-like Receptor 4 (TLR4) Antagonists.
- Selfridge BR1, Wang X2,3, Zhang Y2, Yin H3, Grace PM2, Watkins LR2, Jacobson AE1, Rice KC1.
- Journal of medicinal chemistry.J Med Chem.2015 Jun 25;58(12):5038-52. doi: 10.1021/acs.jmedchem.5b00426. Epub 2015 Jun 5.
- Activation of Toll-like receptors has been linked to neuropathic pain and opioid dependence. (+)-Naltrexone acts as a Toll-like receptor 4 (TLR4) antagonist and has been shown to reverse neuropathic pain in rat studies. We designed and synthesized compounds based on (+)-naltrexone and (+)-noroxymorp
- PMID 26010811
Japanese Journal
- 中枢性鎮痛薬Buprenorphineと中枢神経作用薬との相互作用 鎮痛作用およびHalothane麻酔増強作用による検討
Related Links
- Morphine and Codeine Morphine exerts a narcotic action manifested by analgesia, drowsiness, changes in mood, and mental clouding. The major medical action of morphine sought in the CNS is analgesia. Opiates suppress the ...
- analgesic [an″al-je´zik] 1. relieving pain. 2. pertaining to analgesia. 3. an agent that relieves pain without causing loss of consciousness. narcotic analgesic opioid analgesic. nonsteroidal antiinflammatory analgesic (NSAIA ...
Related Pictures
★リンクテーブル★
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- 関
- drug、narcotic drug、narcotics
[★]
- 関
- analgesic, pain relief, pain management