naphthylvinylpyridine

Naphthylvinylpyridine
Names
	IUPAC name 4-[(E)-2-naphthalen-1-ylethenyl]pyridine
Identifiers
CAS Number	16375-56-7
ECHA InfoCard	100.203.347
Jmol 3D model	Interactive image
PubChem	5475238
	SMILES C1=CC=C2C(=C1)C=CC=C2/C=C/C3=CC=NC=C3 ;
Properties
Chemical formula	C17H13N
Molar mass	231.29 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

ナフチルビニルピリジン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/15 21:26:04」(JST)

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Naphthylvinylpyridine (NVP) is a naphthalene derivative that possesses anticholinergic activity similar to that of atropine. However, NVP's method of acetylcholine (ACh) antagonism involves inhibiting the enzyme choline acetyltransferase.^[1]

Several NVP derivatives have been synthesized and evaluated for their ability to inhibit choline acetyltransferase and protect against nerve toxins.^[2]^[3]

References

^ Haubrich, DR; Goldberg, ME (1975). "Homovanillic acid concentration in the rat brain: Effect of a choline acetyltransferase inhibitor and comparison with cholinergic and dopaminergic agents". Neuropharmacology. Squibb Institute for Medical Research. 14 (3): 211–214. doi:10.1016/0028-3908(75)90007-6. PMID 1134625. Retrieved July 2011. Check date values in: |access-date= (help)
^ Cozzari, Costantino; Hartman, BK (1983). "Synthesis of a naphthylvinylpyridine derivative and its use for affinity chromatography of choline acetyltransferase". Analytical Biochemistry. Department of Psychiatry and Neurobiology, Washington University School of Medicine. 133 (1): 120–125. doi:10.1016/0003-2697(83)90231-2. Retrieved July 2011. Check date values in: |access-date= (help)
^ Gray, AP; Henderson, TR (1988). "Approaches to protection against nerve agent poisoning". J Med Chem. Dynamac Corporation. 31 (4): 807–814. doi:10.1021/jm00399a022. PMID 3351860.

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English Journal

Novel naphthylstyryl-pyridium potentiometric dyes offer advantages for neural network analysis.

Obaid AL1, Loew LM, Wuskell JP, Salzberg BM.
Journal of neuroscience methods.J Neurosci Methods.2004 Apr 30;134(2):179-90.
The submucous plexus of the guinea pig intestine is a quasi-two-dimensional mammalian neural network that is particularly amenable to study using multiple site optical recording of transmembrane voltage (MSORTV) [Biol. Bull. 183 (1992) 344; J. Neurosci. 19 (1999) 3073]. For several years the potenti
PMID 15003384

Molecular modeling of (E)-1-alkyl-4(3)-[2-(1H-azolyl)vinyl]-pyridinium salts and evaluation of their behavior towards choline acetyltransferase.

Alcalde E1, Barat A, Goya P, Martinez A, Ramirez G, Roca T, Rozas I.
Bioorganic & medicinal chemistry.Bioorg Med Chem.1997 May;5(5):949-54.
A new type of extended pi-system aza-analogue of (E)-4-[2-(1-naphthylvinyl)]-1-substituted pyridinium salts (NVP+) has been designed and its inhibitory activity towards choline acetyltransferase (ChAT) has been evaluated in vitro. Among the several examples of the title quaternary salts synthesized
PMID 9208104

The presynaptic component of a cholinergic mechanism in the carotid body chemotransduction of hypoxia in the cat.

Fitzgerald RS1, Shirahata M, Ishizawa Y.
Advances in experimental medicine and biology.Adv Exp Med Biol.1996;410:245-52.
PMID 9030306

Related Pictures

乙烯基吡啶 - CAS号查询 Naphthylvinylpyridine - Wikipedia, the Polychlorinated naphthalene Acene IMAGES VIDEOS Naphthalene is a valuable Naphthalenes File:Naphthylvinylpyridine.png - Wikimedia

[1] Haubrich, DR; Goldberg, ME (1975). "Homovanillic acid concentration in the rat brain: Effect of a choline acetyltransferase inhibitor and comparison with cholinergic and dopaminergic agents". Neuropharmacology. Squibb Institute for Medical Research. 14 (3): 211–214. doi:10.1016/0028-3908(75)90007-6. PMID 1134625. Retrieved July 2011. Check date values in: |access-date= (help)

[2] Cozzari, Costantino; Hartman, BK (1983). "Synthesis of a naphthylvinylpyridine derivative and its use for affinity chromatography of choline acetyltransferase". Analytical Biochemistry. Department of Psychiatry and Neurobiology, Washington University School of Medicine. 133 (1): 120–125. doi:10.1016/0003-2697(83)90231-2. Retrieved July 2011. Check date values in: |access-date= (help)

[3] Gray, AP; Henderson, TR (1988). "Approaches to protection against nerve agent poisoning". J Med Chem. Dynamac Corporation. 31 (4): 807–814. doi:10.1021/jm00399a022. PMID 3351860.

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