naphthylvinylpyridine

Naphthylvinylpyridine
Names
	IUPAC name 4-[(E)-2-naphthalen-1-ylethenyl]pyridine
Identifiers
CAS Number	16375-56-7
ECHA InfoCard	100.203.347
Jmol 3D model	Interactive image
PubChem	5475238
	SMILES C1=CC=C2C(=C1)C=CC=C2/C=C/C3=CC=NC=C3 ;
Properties
Chemical formula	C17H13N
Molar mass	231.29 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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	Infobox references

ナフチルビニルピリジン

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/10/15 21:26:04」(JST)

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Naphthylvinylpyridine (NVP) is a naphthalene derivative that possesses anticholinergic activity similar to that of atropine. However, NVP's method of acetylcholine (ACh) antagonism involves inhibiting the enzyme choline acetyltransferase.^[1]

Several NVP derivatives have been synthesized and evaluated for their ability to inhibit choline acetyltransferase and protect against nerve toxins.^[2]^[3]

References

^ Haubrich, DR; Goldberg, ME (1975). "Homovanillic acid concentration in the rat brain: Effect of a choline acetyltransferase inhibitor and comparison with cholinergic and dopaminergic agents". Neuropharmacology. Squibb Institute for Medical Research. 14 (3): 211–214. doi:10.1016/0028-3908(75)90007-6. PMID 1134625. Retrieved July 2011. Check date values in: |access-date= (help)
^ Cozzari, Costantino; Hartman, BK (1983). "Synthesis of a naphthylvinylpyridine derivative and its use for affinity chromatography of choline acetyltransferase". Analytical Biochemistry. Department of Psychiatry and Neurobiology, Washington University School of Medicine. 133 (1): 120–125. doi:10.1016/0003-2697(83)90231-2. Retrieved July 2011. Check date values in: |access-date= (help)
^ Gray, AP; Henderson, TR (1988). "Approaches to protection against nerve agent poisoning". J Med Chem. Dynamac Corporation. 31 (4): 807–814. doi:10.1021/jm00399a022. PMID 3351860.

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English Journal

Novel naphthylstyryl-pyridium potentiometric dyes offer advantages for neural network analysis.

Obaid AL1, Loew LM, Wuskell JP, Salzberg BM.
Journal of neuroscience methods.J Neurosci Methods.2004 Apr 30;134(2):179-90.
The submucous plexus of the guinea pig intestine is a quasi-two-dimensional mammalian neural network that is particularly amenable to study using multiple site optical recording of transmembrane voltage (MSORTV) [Biol. Bull. 183 (1992) 344; J. Neurosci. 19 (1999) 3073]. For several years the potenti
PMID 15003384

Molecular modeling of (E)-1-alkyl-4(3)-[2-(1H-azolyl)vinyl]-pyridinium salts and evaluation of their behavior towards choline acetyltransferase.

Alcalde E1, Barat A, Goya P, Martinez A, Ramirez G, Roca T, Rozas I.
Bioorganic & medicinal chemistry.Bioorg Med Chem.1997 May;5(5):949-54.
A new type of extended pi-system aza-analogue of (E)-4-[2-(1-naphthylvinyl)]-1-substituted pyridinium salts (NVP+) has been designed and its inhibitory activity towards choline acetyltransferase (ChAT) has been evaluated in vitro. Among the several examples of the title quaternary salts synthesized
PMID 9208104