関: African sleeping sickness、African trypanosomiasis

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/08/03 12:11:44」(JST)

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Cachectic dog infested with Trypanosoma congolense after travel in West Africa

Animal African trypanosomiasis, also known as nagana and nagana pest, is a disease of vertebrate animals. The disease is caused by trypanosomes of several species in the genus Trypanosoma such as Trypanosoma brucei. Trypanosoma vivax causes nagana mainly in West Africa, although it has spread to South America.^[1] The trypanosomes infect the blood of the vertebrate host, causing fever, weakness, and lethargy, which lead to weight loss and anemia; in some animals the disease is fatal unless treated. The trypanosomes are transmitted by tsetse flies.^[2]

An interesting feature is the remarkable tolerance to nagana pathology shown by some breeds of cattle, notably the N'Dama – a West African Bos taurus breed. This contrasts with the susceptibility shown by East African Bos indicus cattle such as the zebu.^[3]

This disease is the nonhuman animal counterpart of human African trypanosomiasis, also known as sleeping sickness.

References

^ Batista JS, Rodrigues CM, García HA, Bezerra FS, Olinda RG, Teixeira MM, Soto-Blanco B (2011). "Association of Trypanosoma vivax in extracellular sites with central nervous system lesions and changes in cerebrospinal fluid in experimentally infected goats". Veterinary Research 42 (63): 1–7. doi:10.1186/1297-9716-42-63. PMC 3105954. PMID 21569364.
^ "Human African trypanosomiasis (sleeping sickness)". WHO.
^ Courtin D, Berthier D, Thevenon S, Dayo GK, Garcia A, Bucheton B (May 2008). "Host genetics in African trypanosomiasis". Infect. Genet. Evol. 8 (3): 229–38. doi:10.1016/j.meegid.2008.02.007. PMID 18394971.

English Journal

Molecular mechanisms of endocrine and metabolic disruption: An in silico study on antitrypanosomal natural products and some derivatives.

Hu Z1, Wahl J1, Hamburger M1, Vedani A2.
Toxicology letters.Toxicol Lett.2016 Jun 11;252:29-41. doi: 10.1016/j.toxlet.2016.04.013. Epub 2016 Apr 16.
The VirtualToxLab is an in silico technology for estimating the toxic potential - endocrine and metabolic disruption, as well as aspects of carcinogenicity and cardiotoxicity - of drugs, chemicals and natural products. The technology is based on an automated protocol that simulates and quantifies th
PMID 27091077

Synthesis of novel amide and urea derivatives of thiazol-2-ethylamines and their activity against Trypanosoma brucei rhodesiense.

Patrick DA1, Wenzler T2, Yang S3, Weiser PT1, Wang MZ3, Brun R2, Tidwell RR4.
Bioorganic & medicinal chemistry.Bioorg Med Chem.2016 Jun 1;24(11):2451-65. doi: 10.1016/j.bmc.2016.04.006. Epub 2016 Apr 2.
2-(2-Benzamido)ethyl-4-phenylthiazole (1) was one of 1035 molecules (grouped into 115 distinct scaffolds) found to be inhibitory to Trypanosoma brucei, the pathogen causing human African trypanosomiasis, at concentrations below 3.6μM and non-toxic to mammalian (Huh7) cells in a phenotypic high-thro
PMID 27102161

Neemazal ® as a possible alternative control tool for malaria and African trypanosomiasis?

Yerbanga RS1, Rayaisse JB2, Vantaux A3,4, Salou E2, Mouline K3,4, Hien F3,4, Habluetzel A5, Dabiré RK3, Ouédraogo JB3, Solano P2,6, Lefèvre T7,8.
Parasites & vectors.Parasit Vectors.2016 May 4;9(1):263. doi: 10.1186/s13071-016-1538-x.
BACKGROUND: Research efforts to identify possible alternative control tools for malaria and African trypanosomiasis are needed. One promising approach relies on the use of traditional plant remedies with insecticidal activities.METHODS: In this study, we assessed the effect of blood treated with dif
PMID 27146309

Japanese Journal

Application of crude and recombinant ELISAs and immunochromatographic test for serodiagnosis of animal trypanosomosis in the Umkhanyakude district of KwaZulu-Natal province, South Africa