ナフチドロフリル、ナフロニル
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/23 21:58:57」(JST)
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Naftidrofuryl
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| Systematic (IUPAC) name |
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(RS)-2-(diethylamino)ethyl 3-(1-naphthyl)-2-(tetrahydrofuran-2-ylmethyl)propanoate
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| Clinical data |
| Trade names |
Praxilene |
| AHFS/Drugs.com |
International Drug Names |
| Legal status |
- UK: Prescription-only (POM)
|
Routes of
administration |
Oral |
| Pharmacokinetic data |
| Metabolism |
Hepatic |
| Biological half-life |
1 - 3.5 hours |
| Identifiers |
| CAS Registry Number |
31329-57-4 Y |
| ATC code |
C04AX21 |
| PubChem |
CID: 4417 |
| ChemSpider |
4264 Y |
| UNII |
42H8PQ0NMJ Y |
| ChEMBL |
CHEMBL1620794 |
| Chemical data |
| Formula |
C24H33NO3 |
| Molecular mass |
383.524 g/mol |
SMILES
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O=C(OCCN(CC)CC)C(Cc2c1ccccc1ccc2)CC3OCCC3
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InChI
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InChI=1S/C24H33NO3/c1-3-25(4-2)14-16-28-24(26)21(18-22-12-8-15-27-22)17-20-11-7-10-19-9-5-6-13-23(19)20/h5-7,9-11,13,21-22H,3-4,8,12,14-18H2,1-2H3 Y
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Key:KBAFPSLPKGSANY-UHFFFAOYSA-N Y
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| Y (what is this?) (verify) |
Naftidrofuryl (INN, also known as nafronyl or as the oxalate salt naftidrofuryl oxalate or nafronyl oxalate) is a drug used in the management of peripheral and cerebral vascular disorders as a vasodilator. It is also claimed to enhance cellular oxidative capacity, and may also be a 5-HT2 receptor antagonist.[1] It is also licenced for the treatment of intermittent claudication due to peripheral arterial disease.
Naftidrofuryl is marketed under the trade names Artocoron; Azunaftil; Di-Actane; Dusodril; Enelbin; Frilix; Gevatran; Iridus; Iridux; Luctor; Nafti; Naftoling; Naftodril; Nafoxal; Praxilene; Sodipryl retard; Vascuprax.
Historically, it has been used to treat sudden idiopathic hearing loss and acute tinnitus.[2]
Naftidrofuryl may be effective for relieving the pain of muscle cramps.[3]
Synthesis
Prepn: Szarvasi, Bayssat,
FR 1363948 corresp to
U.S. Patent 3,334,096 (1964, 1967 both to LIPHA);
[4] eidem
[5]
Adverse Effects
Naftidrofuryl has been associated with nausea, abdominal pain and rash. Rarely, hepatitis and liver failure have been reported.[1]
References
- ^ a b Brayfield, A, ed. (14 January 2014). "Naftidrofuryl Oxalate". Martindale: The Complete Drug Reference. Pharmaceutical Press. Retrieved 6 August 2014.
- ^ http://www.der-arzneimittelbrief.de/Jahrgang2004/Ausgabe12Seite89.htm
- ^ Katzberg HD, Khan AH, So YT (February 2010). "Assessment: Symptomatic treatment for muscle cramps (an evidence-based review): Report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology". Neurology 74 (8): 691–6. doi:10.1212/WNL.0b013e3181d0ccca. PMID 20177124.
- ^ Szarvasi et al., Compt. Rend. 260, 3095 (1965).
- ^ Bull. Soc. Chim. Fr. 1966, 1838.
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Peripheral vasodilators (C04)
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|
| Phenylethanolamine derivatives |
- Isoxsuprine
- Buphenine
- Bamethan
|
|
Imidazoline derivatives/
Alpha blockers |
|
|
| Niacin and derivatives |
- Niacin
- Nicotinyl alcohol
- Inositol nicotinate
- Ciclonicate
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|
| Purine derivatives |
- Pentifylline
- Xantinol nicotinate
- Pentoxifylline
- Etofylline nicotinate
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| Ergot alkaloids |
- Ergoloid
- Nicergoline
- Dihydroergocristine
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| Other peripheral vasodilators |
- Cyclandelate
- Phenoxybenzamine
- Vincamine
- Moxisylyte
- Bencyclane
- Vinburnine
- Sulcotidil
- Buflomedil
- Naftidrofuryl
- Butalamine
- Visnadine
- Cetiedil
- Cinepazide
- Ifenprodil
- Azapetine
- Fasudil
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|
|
Index of the circulatory system
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|
| Description |
- Anatomy
- Arteries
- head and neck
- arms
- chest
- abdomen
- legs
- Veins
- head and neck
- arms
- chest
- abdomen and pelvis
- legs
- Development
- Cells
- Physiology
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|
| Disease |
- Congenital
- Neoplasms and cancer
- Lymphatic vessels
- Injury
- Vasculitis
- Other
- Symptoms and signs
|
|
| Treatment |
- Procedures
- Drugs
- beta blockers
- channel blockers
- diuretics
- nonsympatholytic vasodilatory antihypertensives
- peripheral vasodilators
- renin–angiotensin system
- sympatholytic antihypertensives
- vasoprotectives
|
|
|
English Journal
- Non-Invasive Therapy of Peripheral Arterial Disease.
- Marcial JM, Pérez R, Vargas P, Franqui-Rivera H.
- Boletín de la Asociación Médica de Puerto Rico.Bol Asoc Med P R.2015 Jul-Sep;107(3):52-7.
- Peripheral arterial disease (PAD) is a significant cause of morbidity and mortality worldwide. Lifestyle changes, like the cessation of the use of tobacco as well as a modification of dietary and exercise habits, can be the most cost-effective interventions in patients with PAD. Smocking cessation i
- PMID 26742197
- Incidentally diagnosed melorheostosis of upper limb: case report.
- Vyskocil V1, Koudela K Jr2, Pavelka T3, Stajdlova K4, Suchy D5.
- BMC musculoskeletal disorders.BMC Musculoskelet Disord.2015 Jan 31;16:2. doi: 10.1186/s12891-015-0455-z.
- BACKGROUND: Melorheostosis is quite a rare bone disease with still unclear ethiology. Although multifocal affection is highly debilitating with unfavorable prognosis, there is no clear consensus about therapeutical approach. There is still insufficient evidence in the literature for almost a century
- PMID 25637225
- A case of acute bilateral retrocochlear hearing loss as an initial symptom of unilateral thalamic hemorrhage.
- Park MJ1, Yoon SW1, Kim KH1, Kim YJ1.
- Korean journal of audiology.Korean J Audiol.2014 Sep;18(2):80-4. doi: 10.7874/kja.2014.18.2.80. Epub 2014 Sep 16.
- A speech discrimination test is a test using a list of 25 phonetically balanced monosyllables. It is often overlooked but significant enough for pure tone audiometry. Many physicians have performed pure tone audiometry but without a speech discrimination test. A 73-year-old woman visited our clinic
- PMID 25279230
Japanese Journal
- Acute kidney injury associated with nafronyl oxalate overdose
- Clinical and experimental nephrology 17(3), 437-438, 2013-06-01
- NAID 10031184253
- Treatment of Intermittent Claudication With Physical Training, Smoking Cessation, Pentoxifylline, or Nafronyl
Related Links
- Definition of Nafronyl in the Definitions.net dictionary. Meaning of Nafronyl. What does Nafronyl mean? Information and translations of Nafronyl in the most comprehensive dictionary definitions resource on the web.
- Buy Nafronyl (CAS 31329-57-4), a vasodilator, from Santa Cruz Biotechnology. Molecular Formula: C24H33NO3 ... 試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
Related Pictures
★リンクテーブル★
[★]
- 英
- naftidrofuryl
- 関
- ナフロニル nafronyl
- 末梢性血管弛緩薬;5-HT2遮断薬
- 日本では発売されていない。
参考
[★]
- 英
- nafronyl
- 関
- ナフチドロフリル