WordNet
- sarcoma of fat cells
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/08 13:52:25」(JST)
[Wiki en表示]
| Myxoid liposarcoma |
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Histopathologic image of myxoid liposarcoma arising in the deep soft tissue of the thigh. H & E stain.
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| Classification and external resources |
| ICD-O |
8852/3 |
| OMIM |
613488 |
| MeSH |
D018208 |
A myxoid liposarcoma is a malignant adipose tissue neoplasm.
It is associated with a fusion between DDIT3 or "CHOP" (at 12q13.1-q13.2) and FUS or "TLS" (at 16p11.2) or EWS (at 22q12.2).[1]
The specific translocation of FUS-DDIT3 is t(12;16)(q13;p11).[2]
References
- ^ Forni C, Minuzzo M, Virdis E et al. (February 2009). "Trabectedin (ET-743) promotes differentiation in myxoid liposarcoma tumors". Mol. Cancer Ther. 8 (2): 449–57. doi:10.1158/1535-7163.MCT-08-0848. PMID 19190116.
- ^ Göransson M, Andersson MK, Forni C et al. (January 2009). "The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ". Oncogene 28 (2): 270–8. doi:10.1038/onc.2008.378. PMID 18850010.
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Connective/soft tissue tumors and sarcomas (ICD-O 8800–9059) (C45–C49/D17–D21, 171/214–215)
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| Not otherwise specified |
- Soft-tissue sarcoma
- Desmoplastic small-round-cell tumor
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| Connective tissue neoplasm |
| Fibromatous |
| Fibroma/fibrosarcoma: |
- Dermatofibrosarcoma protuberans
- Desmoplastic fibroma
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| Fibroma/fibromatosis: |
- Aggressive infantile fibromatosis
- Aponeurotic fibroma
- Collagenous fibroma
- Diffuse infantile fibromatosis
- Familial myxovascular fibromas
- Fibroma of tendon sheath
- Fibromatosis colli
- Infantile digital fibromatosis
- Juvenile hyaline fibromatosis
- Plantar fibromatosis
- Pleomorphic fibroma
- Oral submucous fibrosis
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| Histiocytoma/histiocytic sarcoma: |
- Benign fibrous histiocytoma
- Malignant fibrous histiocytoma
- Atypical fibroxanthoma
- Solitary fibrous tumor
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| Myxomatous |
- Myxoma/myxosarcoma
- Cutaneous myxoma
- Superficial acral fibromyxoma
- Angiomyxoma
- Ossifying fibromyxoid tumour
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| Fibroepithelial |
- Brenner tumour
- Fibroadenoma
- Phyllodes tumor
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| Synovial-like |
- Synovial sarcoma
- Clear-cell sarcoma
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| Lipomatous |
- Lipoma/liposarcoma
- Myelolipoma
- Myxoid liposarcoma
- PEComa
- Chondroid lipoma
- Intradermal spindle cell lipoma
- Pleomorphic lipoma
- Lipoblastomatosis
- Spindle cell lipoma
- Hibernoma
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| Myomatous |
| general: |
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| smooth muscle: |
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| skeletal muscle: |
- Rhabdomyoma/rhabdomyosarcoma: Embryonal rhabdomyosarcoma
- Alveolar rhabdomyosarcoma
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- Leiomyoma
- Angioleiomyoma
- Angiolipoleiomyoma
- Genital leiomyoma
- Leiomyosarcoma
- Multiple cutaneous and uterine leiomyomatosis syndrome
- Multiple cutaneous leiomyoma
- Neural fibrolipoma
- Solitary cutaneous leiomyoma
- STUMP
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| Complex mixed and stromal |
- Adenomyoma
- Pleomorphic adenoma
- Mixed Müllerian tumor
- Mesoblastic nephroma
- Wilms' tumor
- Malignant rhabdoid tumour
- Clear-cell sarcoma of the kidney
- Hepatoblastoma
- Pancreatoblastoma
- Carcinosarcoma
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| Mesothelial |
- Mesothelioma
- Adenomatoid tumor
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Index of muscle
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| Description |
- Anatomy
- head
- neck
- arms
- chest and back
- diaphragm
- abdomen
- genital area
- legs
- Muscle tissue
- Physiology
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| Disease |
- Myopathy
- Soft tissue
- Connective tissue
- Congenital
- abdomen
- muscular dystrophy
- Neoplasms and cancer
- Injury
- Symptoms and signs
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| Treatment |
- Procedures
- Drugs
- anti-inflammatory
- muscle relaxants
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Chromosome abnormalities (Q90–Q99, 758)
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| Autosomal |
| Trisomies |
- Down syndrome
- Edwards syndrome
- Patau syndrome
- Trisomy 9
- Warkany syndrome 2
- Cat eye syndrome/Trisomy 22
- Trisomy 16
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| Monosomies/deletions |
- 1q21.1 deletion syndrome/1q21.1 duplication syndrome/TAR syndrome
- Wolf–Hirschhorn syndrome
- Cri du chat/Chromosome 5q deletion syndrome
- Williams syndrome
- Jacobsen syndrome
- Miller–Dieker syndrome/Smith–Magenis syndrome
- DiGeorge syndrome
- 22q11.2 distal deletion syndrome
- 22q13 deletion syndrome
- genomic imprinting
- Angelman syndrome/Prader–Willi syndrome (15)
- Distal 18q-/Proximal 18q-
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| X/Y linked |
| Monosomy |
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Trisomy/tetrasomy,
other karyotypes/mosaics |
- Klinefelter syndrome (47,XXY)
- 48,XXYY
- 48,XXXY
- 49,XXXYY
- 49,XXXXY
- Triple X syndrome (47,XXX)
- 48,XXXX
- 49,XXXXX
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| Translocations |
| Leukemia/lymphoma |
| Lymphoid |
- Burkitt's lymphoma t(8 MYC;14 IGH)
- Follicular lymphoma t(14 IGH;18 BCL2)
- Mantle cell lymphoma/Multiple myeloma t(11 CCND1:14 IGH)
- Anaplastic large cell lymphoma t(2 ALK;5 NPM1)
- Acute lymphoblastic leukemia
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| Myeloid |
- Philadelphia chromosome t(9 ABL; 22 BCR)
- Acute myeloblastic leukemia with maturation t(8 RUNX1T1;21 RUNX1)
- Acute promyelocytic leukemia t(15 PML,17 RARA)
- Acute megakaryoblastic leukemia t(1 RBM15;22 MKL1)
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| Other |
- Ewing's sarcoma t(11 FLI1; 22 EWS)
- Synovial sarcoma t(x SYT;18 SSX)
- Dermatofibrosarcoma protuberans t(17 COL1A1;22 PDGFB)
- Myxoid liposarcoma t(12 DDIT3; 16 FUS)
- Desmoplastic small round cell tumor t(11 WT1; 22 EWS)
- Alveolar rhabdomyosarcoma t(2 PAX3; 13 FOXO1) t (1 PAX7; 13 FOXO1)
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| Other |
- Fragile X syndrome
- Uniparental disomy
- XX male syndrome
- Ring chromosome (13; 14; 15; 20)
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Index of developmental medicine
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| Description |
- Embryology
- Cell lines
- Stem cells
- endoderm
- mesoderm
- ectoderm
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| Disease |
- Due to toxins
- Syndromes
- Chromosomal
- Neonate
- Twins
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UpToDate Contents
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English Journal
- Correlation of Classic and Molecular Cytogenetic Alterations in Soft-Tissue Sarcomas: Analysis of 46 Tumors With Emphasis on Adipocytic Tumors and Synovial Sarcoma.
- Rao UN1, Cieply K, Sherer C, Surti U, Gollin SM.
- Applied immunohistochemistry & molecular morphology : AIMM / official publication of the Society for Applied Immunohistochemistry.Appl Immunohistochem Mol Morphol.2016 Jan 22. [Epub ahead of print]
- INTRODUCTION: Sarcomas are heterogeneous, and their treatment and prognosis are driven by the morphologic subtype and the clinical stage. Classic cytogenetics and fluorescence in situ hybridization (FISH) analysis play an important role in their diagnostic work up.MATERIALS AND METHODS: Forty-six ca
- PMID 26808135
- Retroperitoneal mass presenting as recurrent inguinal hernia: A case report.
- Tardu A1, Yagci MA2, Karagul S2, Ertugrul I2, Kayaalp C2.
- International journal of surgery case reports.Int J Surg Case Rep.2016 Jan 14;20:46-48. doi: 10.1016/j.ijscr.2016.01.005. [Epub ahead of print]
- INTRODUCTION: Retroperitoneal masses presenting as an inguinal hernia are rare conditions.PRESENTATION OF CASE: A 53 year old male admitted with the symptoms of weight loss, abdominal discomfort and left sided recurrent inguinal hernia. Physical examination demonstrated an abdominal mass in the left
- PMID 26812669
- Immunohistochemical expression of p16 in lipoblastomas.
- Cappellesso R1, d'Amore ES2, Dall'Igna P3, Guzzardo V1, Vassarotto E1, Rugge M1, Alaggio R4.
- Human pathology.Hum Pathol.2016 Jan;47(1):64-9. doi: 10.1016/j.humpath.2015.08.019. Epub 2015 Sep 21.
- Lipoblastoma (LB) is a rare benign adipocytic tumor of childhood occasionally showing histological similarities to myxoid liposarcoma (ML) or well-differentiated liposarcoma (WDL). p16 immunohistochemistry has proved to be useful in distinguishing various types of liposarcomas, in particular WDL fro
- PMID 26514741
Japanese Journal
- 黒河内 顕,俵藤 正信,佐田 尚宏,山口 岳彦,仁木 利郎,永井 秀雄,安田 是和
- 日本臨床外科学会雑誌 = The journal of the Japan Surgical Association 72(8), 2129-2133, 2011-08-25
- NAID 10029614527
- Lipoblastoma Mimicking Myxoid Liposarcoma : A Clinical Report and Literature Review
- NAGANO Akihito,OHNO Takatoshi,NISHIMOTO Yutaka,HIROSE Yoshinobu,MIYAKE Satoru,SHIMIZU Katsuji
- Tohoku journal of experimental medicine 223(1), 75-78, 2011-01-01
- NAID 10027806725
Related Links
- Lipoma, myxoid liposarcoma and retroperitoneal liposarcoma are explained for patients and practitioners, with patient stories and support group listings. ... Liposarcoma was originally described by R. Virchow in 1857. In 1944, Arthur ...
- What is a Myxoid Liposarcoma? Myxiod liposarcoma tumors usually appear in the fatty tissue of the thighs or upper arms. Late-stage liposarcomas are typically treated with chemotherapy. A diagnosis of myxoid liposarcoma is ...
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