関: myosin light chain

WordNet

very thin and insubstantial; "thin paper"; "light summer dresses"
make lighter or brighter; "This lamp lightens the room a bit" (同)illume, illumine, light_up, illuminate
a condition of spiritual awareness; divine illumination; "follow Gods light" (同)illumination
having abundant light or illumination; "they played as long as it was light"; "as long as the lighting was good" (同)lighting
(physics) electromagnetic radiation that can produce a visual sensation; "the light was filtered through a soft glass window" (同)visible_light, visible_radiation
any device serving as a source of illumination; "he stopped the car and turned off the lights" (同)light_source
the visual effect of illumination on objects or scenes as created in pictures; "he could paint the lightest light and the darkest dark" (同)lightness
a particular perspective or aspect of a situation; "although he saw it in a different light, he still did not understand"
a person regarded very fondly; "the light of my life"
a visual warning signal; "they saw the light of the beacon"; "there was a light at every corner"
an illuminated area; "he stepped into the light"
mental understanding as an enlightening experience; "he finally saw the light"; "can you shed light on this problem?"
public awareness; "it brought the scandal to light"
(used of color) having a relatively small amount of coloring agent; "light blue"; "light colors such as pastels"; "a light-colored powder" (同)light-colored
moving easily and quickly; nimble; "the dancer was light and graceful"; "a lightsome buoyant step"; "walked with a light tripping step" (同)lightsome, tripping
having relatively few calories; "diet cola"; "light (or lite) beer"; "lite (or light) mayonnaise"; "a low-cal diet" (同)lite, low-cal, calorie-free
less than the correct or legal or full amount often deliberately so; "a light pound"; "a scant cup of sugar"; "regularly gives short weight" (同)scant, short
(of sleep) easily disturbed; "in a light doze"; "a light sleeper"; "a restless wakeful night" (同)wakeful
(physics, chemistry) not having atomic weight greater than average; "light water is ordinary water"
(used of soil) loose and large-grained in consistency; "light soil"
characterized by or emitting light; "a room that is light when the shutters are open"; "the inside of the house was airy and light"
demanding little effort; not burdensome; "light housework"; "light exercise"
designed for ease of movement or to carry little weight; "light aircraft"; "a light truck"
easily assimilated in the alimentary canal; not rich or heavily seasoned; "a light diet"
having little importance; "losing his job was no light matter"
intended primarily as entertainment; not serious or profound; "light verse"; "a light comedy"
not great in degree or quantity or number; "a light sentence"; "a light accent"; "casualties were light"; "light snow was falling"; "light misty rain"; "light smoke from the chimney"
of comparatively little physical weight or density; "a light load"; "magnesium is a light metal--having a specific gravity of 1.74 at 20 degrees C"
of little intensity or power or force; "the light touch of her fingers"; "a light breeze"
of the military or industry; using (or being) relatively small or light arms or equipment; "light infantry"; "light cavalry"; "light industry"; "light weapons"
psychologically light; especially free from sadness or troubles; "a light heart"
fasten or secure with chains; "Chain the chairs together"
a unit of length
a necklace made by a stringing objects together; "a string of beads"; "a strand of pearls"; (同)string, strand
a linked or connected series of objects; "a chain of daisies"
a series of (usually metal) rings or links fitted into one another to make a flexible ligament
anything that acts as a restraint
(chemistry) a series of linked atoms (generally in an organic molecule) (同)chemical chain
a series of things depending on each other as if linked together; "the chain of command"; "a complicated concatenation of circumstances" (同)concatenation
(business) a number of similar establishments (stores or restaurants or banks or hotels or theaters) under one ownership
connect or arrange into a chain by linking
any of various controls or devices for regulating or controlling fluid flow, pressure, temperature, etc.
an official responsible for control and supervision of a particular activity or area of public interest
apparatus for supplying artificial light effects for the stage or a film
the craft of providing artificial light; "an interior decorator must understand lighting"
British biochemist (born in Germany) who isolated and purified penicillin, which had been discovered in 1928 by Sir Alexander Fleming (1906-1979) (同)Ernst Boris Chain, Sir Ernst Boris Chain

PrepTutorEJDIC

〈U〉『光,光線』;明るさ / 〈U〉夜明け;日中;日光 / 〈C〉『明かり』(太陽・灯火など光を出すもの) / 〈U〉《時にa~》光輝(brightness),(目などの)輝き / 〈C〉(点火するための)火,火花 / 〈C〉明かり採り,採光窓 / 〈C〉《通例単数形で》(絵などの)明るい部分 / 〈U〉(…についての)知識,情報,理解《+『on』+『名』》 / 〈C〉(ものを見る)観点,見地;相 / 〈C〉この世に光を与える人;指導的な人物 / …‘に'『火をつける』《+『up』+『名』+『名』+『up』》 / …‘に'『明かりをつける』,‘を'照らす《+『up』+『名,』+『名』+『up』》 / 〈人〉‘を'明かりをつけて案内する / 〈表情など〉‘を'明るくする《+『up』+『名,』+『名』+『up』》 / 〈物が〉火がつく,点火する;明かりがつく《+『up』》 / 明るくなる,晴れ晴れする《+『up』》 / 『明るい』 / (色が)『薄い』
(重量が)『軽い』 / (いろいろな事について,その程座・量が)軽い,小さい / 『軽快な』 / 軽装の / 肩のこらない;気軽な / 手軽な,骨の折れなし / (食べ物が)消化のよい,もたれない / ふらふらする,目まいのする / アルコール分の少ない / (パンなどが)ふんわりした / (重量が)軽く / (程度が)軽く,容易に;軽装で
(車・馬などから)降りる《+『from』+『名』》(alight) / (木などに)〈鳥などが〉止まる《+『on』(『upon』)+『名』》 / (…に)〈打撃・運などが〉突然ふりかかる《+『on』(『upon』)+『名』》
『鎖』;(装飾用の)鎖 / 《複数形で》『束縛』,拘束;囚人をつなぐ鎖 / (物事の)『連続』,つながり《+『of』+『名』》 / (商店・銀行・ホテルなどの)チェーン(一連の店が同一資本のもとで連携して経営される方式;その店) / チェーン(測量で用いられる単位;約21.7m) / …'を'『鎖でつなぐ』《+『up』(『together』)+『名,』+『名』+『up』(『together』)》
取り締まり人;調整者 / 調整装置
照明,点火 / 照明方法(装置)

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1. 肥大型心筋症：遺伝子変異および臨床遺伝子検査 hypertrophic cardiomyopathy gene mutations and clinical genetic testing

English Journal

Identification of novel mutations including a double mutation in patients with inherited cardiomyopathy by a targeted sequencing approach using the Ion Torrent PGM system.

Zhao Y1, Cao H2, Song Y2, Feng Y1, Ding X2, Pang M2, Zhang Y2, Zhang H2, Ding J1, Xia X1.
International journal of molecular medicine.Int J Mol Med.2016 Jun;37(6):1511-20. doi: 10.3892/ijmm.2016.2565. Epub 2016 Apr 14.
Inherited cardiomyopathy is the major cause of sudden cardiac death (SCD) and heart failure (HF). The disease is associated with extensive genetic heterogeneity; pathogenic mutations in cardiac sarcomere protein genes, cytoskeletal protein genes and nuclear envelope protein genes have been linked
PMID 27082122

Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning.

Keul P1, van Borren MM2, Ghanem A3, Müller FU4, Baartscheer A2, Verkerk AO2, Stümpel F4, Schulte JS4, Hamdani N5, Linke WA5, van Loenen P6, Matus M7, Schmitz W4, Stypmann J8, Tiemann K8, Ravesloot JH2, Alewijnse AE6, Hermann S9, Spijkers LJ6, Hiller KH10, Herr D11, Heusch G1, Schäfers M9, Peters SL6, Chun J11, Levkau B12.
Journal of the American Heart Association.J Am Heart Assoc.2016 May 20;5(5). pii: e003393.
BACKGROUND: Sphingosine-1-phosphate plays vital roles in cardiomyocyte physiology, myocardial ischemia-reperfusion injury, and ischemic preconditioning. The function of the cardiomyocyte sphingosine-1-phosphate receptor 1 (S1P1) in vivo is unknown.METHODS AND RESULTS: Cardiomyocyte-restricted delet
PMID 27207969

Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments.

Kampourakis T1, Sun YB1, Irving M2.
Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2016 May 9. pii: 201602776. [Epub ahead of print]
Contraction of heart muscle is triggered by calcium binding to the actin-containing thin filaments but modulated by structural changes in the myosin-containing thick filaments. We used phosphorylation of the myosin regulatory light chain (cRLC) by the cardiac isoform of its specific kinase to elucid
PMID 27162358

Japanese Journal

Compressive Stress Induces Dephosphorylation of the Myosin Regulatory Light Chain via RhoA Phosphorylation by the Adenylyl Cyclase/Protein Kinase A Signaling Pathway

Takemoto Kenji,Ishihara Seiichiro,Mizutai Takeomi,Kawabata Kazushige,Haga Hisashi
PLOS ONE 10(3), e0117937, 2015-03-03
… For example, stretching induces phosphorylation of the myosin regulatory light chain (MRLC) via the RhoA/RhoA-associated protein kinase (ROCK) pathway, resulting in increased cellular tension. … Compressive loading induced activation of myosin phosphatase mediated via the dephosphorylation of myosin phosphatase targeting subunit 1 (Thr853). …
NAID 120005613567

Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen Matrices

Iguchi Yuta,Ishihara Seiichiro,Uchida Yoshimi,Tajima Kaori,Mizutani Takeomi,Kawabata Kazushige,Haga Hisashi
Cell Structure and Function 40(2), 61-67, 2015
… Furthermore, di-phosphorylation of myosin regulatory light chain (MRLC) and phosphorylation of focal adhesion kinase (FAK) are inhibited in FLNb-knockdown cancer cells. …
NAID 130005086307

Filamin B enhances the invasiveness of cancer cells into 3D collagen matrices

Iguchi Yuta,Ishihara Seiichiro,Uchida Yoshimi,Tajima Kaori,Mizutani Takeomi,Kawabata Kazushige,Haga Hisashi
Cell Structure and Function advpub(0), 2015
… Furthermore, di-phosphorylation of myosin regulatory light chain (MRLC) and phosphorylation of focal adhesion kinase (FAK) are inhibited in FLNb-knockdown cancer cells. …
NAID 130005068192