"Myofiber" redirects here. For protein structures inside cells, see Myofibril.
Overall structure of a muscle cell and neuromuscular junction:
1. Axon
2. Neuromuscular junction
3. Muscle fiber (Myocyte)
4. Myofibril
A myocyte (also known as a muscle cell or muscle fiber)[1] is the type of cell found in muscle tissue. They are long, tubular cells that arise developmentally from myoblasts to form muscles.[2] There are various specialized forms of myocytes: cardiac, skeletal, and smooth muscle cells, with various properties. Cardiac myocytes are responsible for generating the electrical impulses that control the heart rate, among other things.
Contents
- 1 Terminology
- 2 Myofibrils
- 3 Functional control
- 4 Myoblasts
- 5 See also
- 6 References
- 7 External links
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Terminology
The unusual microstructure of muscle cells has led cell biologists to create specialized terminology. However, each term specific to muscle cells has a counterpart that is used in the terminology applied to other types of cells:
Muscle cell |
Other organismal cells |
sarcoplasm |
cytoplasm |
sarcoplasmic reticulum |
smooth endoplasmic reticulum (SER) |
sarcosome |
mitochondrion |
sarcolemma |
cell membrane or plasma membrane |
Myofibrils
Main articles: Myofibril and Sarcomere
Portion of a myofibril, showing sarcomere structure:
S = Sarcomere, unit of muscle function
A = A-band, region of myosin
I = I-band, region of actin
H = H-zone, region of just myosin
Z = Z-line, sarcomere boundary
M = M-line, sarcomere center
Each myocyte contains myofibrils, which are very long chains of sarcomeres, the contractile units of the cell. A cell from the biceps brachii muscle may contain 100,000 sarcomeres.[3] The myofibrils of smooth muscle cells are not arranged into sarcomeres. The sarcomeres are composed of thin and thick filaments. Thin filaments are actin filaments, whereas thick filaments consist of an arrangement of myosin proteins. The sarcomere does not contain organelles or a nucleus. Individual muscle fibrils are surrounded by endomysium.
Within the muscle cell, the myofibrils are bound together by perimysium into bundles called fascicles; the bundles are then grouped together to form muscle tissue, which is enclosed in a sheath of epimysium. Muscle spindles are distributed throughout the muscles and provide sensory feedback information to the central nervous system.
Functional control
Kindlin-2 plays a role in elongation.[4]
GATA4 and GATA6 play a role in differentiation.[5]
Myoblasts
A myoblast is a type of embryonic progenitor cell that differentiates to give rise to muscle cells.[6]
Skeletal muscle fibers are made when myoblasts fuse together; muscle fibers therefore have multiple nuclei (each nucleus originating from a single myoblast). The fusion of myoblasts is specific to skeletal muscle (e.g., biceps brachii) and not cardiac muscle or smooth muscle.
Myoblasts that do not form muscle fibers dedifferentiate back into satellite cells. These satellite cells remain adjacent to a muscle fiber, situated between the sarcolemma and the endomysium (the connective tissue investment that divides the muscle fascicles into individual fibers).
See also
References
- ^ "myocyte" at Dorland's Medical Dictionary
- ^ Myocytes at the US National Library of Medicine Medical Subject Headings (MeSH)
- ^ Assuming that the length of biceps is 20 cm and the length of sarcomere is 2 micrometer, there are 100,000 sarcomeres along the length of biceps.
- ^ Dowling JJ, Vreede AP, Kim S, Golden J, Feldman EL (2008). "Kindlin-2 is required for myocyte elongation and is essential for myogenesis". BMC Cell Biol. 9: 36. doi:10.1186/1471-2121-9-36. PMC 2478659. PMID 18611274. http://www.biomedcentral.com/1471-2121/9/36.
- ^ Zhao R, Watt AJ, Battle MA, Li J, Bondow BJ, Duncan SA (May 2008). "Loss of both GATA4 and GATA6 blocks cardiac myocyte differentiation and results in acardia in mice". Dev. Biol. 317 (2): 614–9. doi:10.1016/j.ydbio.2008.03.013. PMC 2423416. PMID 18400219. http://linkinghub.elsevier.com/retrieve/pii/S0012-1606(08)00219-4.
- ^ page 395, Biology, Fifth Edition, Campbell, 1999
External links
- http://www.ivy-rose.co.uk/HumanBody/Muscles/Muscle_Cell.php [1]
Histology: Muscle tissue (TH H2.00.05, H3.3)
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Smooth
muscle |
Calmodulin · Vascular smooth muscle
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Striated
muscle |
Skeletal
muscle
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Costamere/
DAPC
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Membrane/
extracellular
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DAP: Sarcoglycan (SGCA, SGCB, SGCD, SGCE, SGCG, SGCZ) · Dystroglycan
Sarcospan · Laminin, alpha 2
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Intracellular
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Dystrophin · Dystrobrevin (A, B) · Syntrophin (A, B1, B2, G1, G2) · Syncoilin · Dysbindin · Synemin/desmuslin
related: NOS1 · Caveolin 3
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Sarcomere/
(a, i, and h bands;
z and m lines)
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Myofilament (thin filament/actin, thick filament/myosin, elastic filament/titin, nebulin)
Tropomyosin
Troponin (T, C, I)
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Connective tissue
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Epimysium · Fascicle · Perimysium · Endomysium · Connective tissue in skeletal muscle
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General
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Neuromuscular junction · Motor unit · Muscle spindle · Excitation-contraction coupling · Sliding filament mechanism
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Cardiac
muscle
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Myocardium · Intercalated disc · Nebulette
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Both
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Fiber
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Muscle fiber (intrafusal, extrafusal) · Myofibril · Microfilament/Myofilament · Sarcomere
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Cells
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Myoblast/Myocyte · Myosatellite cell
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Other
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Desmin · Sarcoplasm · Sarcolemma (T-tubule) · Sarcoplasmic reticulum
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Other/
ungrouped
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Myotilin · Telethonin · Dysferlin · Fukutin · Fukutin-related protein
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anat (h/n, u, t/d, a/p, l)/phys/devp/hist
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noco(m, s, c)/cong(d)/tumr, sysi/epon, injr
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Human cell types / list derived primarily from mesoderm
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Paraxial |
Cartilage/bone/
muscle
(MSC)
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OCP
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bone: Osteoblast → Osteocyte
cartilage: Chondroblast → Chondrocyte
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Myofibroblast
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Fibroblast → Fibrocyte
muscle: Myoblast → Myocyte · Myosatellite cell · Tendon cell · Cardiac muscle cell
adipose: Lipoblast → Adipocyte
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Digestive system
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Interstitial cell of Cajal
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Intermediate |
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Urinary system (RSC)
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Angioblast → Endothelial cell · Mesangial cell (Intraglomerular, Extraglomerular) · Juxtaglomerular cell · Macula densa cell
Stromal cell → Interstitial cell → Telocytes
Simple epithelial cell → Podocyte · Kidney proximal tubule brush border cell
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Reproductive system
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Sertoli cell · Leydig cell · Granulosa cell · Peg cell · (spermatozoon and ovum are germ cells)
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Lateral plate/
hemangioblast |
Blood/immune
(HSC)
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Lymphoid (CFU-L)
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see lymphocytes
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Myeloid (CFU-GEMM)
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see myeloid cells
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Circulatory system
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Endothelial progenitor cell · Endothelial stem cell · Angioblast/Mesoangioblast · Pericyte · Mural cell
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anat(c/f/k/f, u, t/p, l)/phys/devp/cell
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noco/cong/tumr, sysi/epon, injr
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noco/acba/cong/tumr, sysi/epon, urte
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proc/itvp, drug (G4B), blte, urte
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anat(a:h/u/t/a/l,v:h/u/t/a/l)/phys/devp/cell/prot
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noco/syva/cong/lyvd/tumr, sysi/epon, injr
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proc, drug(C2s+n/3/4/5/7/8/9)
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