Carboxyzincation Employing Carbon Dioxide and Zinc Powder: Cobalt-Catalyzed Multicomponent Coupling Reactions with Alkynes.
Nogi K1, Fujihara T1, Terao J1, Tsuji Y1.
Journal of the American Chemical Society.J Am Chem Soc.2016 May 4;138(17):5547-50. doi: 10.1021/jacs.6b02961. Epub 2016 Apr 22.
Cobalt-catalyzed carboxyzincation reactions employing carbon dioxide and zinc metal powder are developed. By using alkynes as substrates, regio- and stereodefined (Z)-β-zincated acrylates are provided. The corresponding alkenylzinc moiety can be converted to various substituents, affording multisub
Anomalous Reactivity and Selectivity in the Intermolecular Diels-Alder Reactions of Multisubstituted Acyclic Dienes with Geometrical Isomers of Enals.
Zhou JH1, Cai SH1, Xu YH1, Loh TP1,2.
Organic letters.Org Lett.2016 May 2. [Epub ahead of print]
A Lewis-acid catalyzed intermolecular Diels-Alder reaction between multisubstituted acyclic dienes and the E and Z isomers of α,β-enals was studied. It was found that the diene reacted selectively with the Z-isomer of the α,β-enal.
Angewandte Chemie (International ed. in English).Angew Chem Int Ed Engl.2016 Apr 28. doi: 10.1002/anie.201601915. [Epub ahead of print]
Taking advantage of a 6π electrocyclization-aromatization strategy, we accomplished the first and asymmetric total synthesis of rubriflordilactone B, a heptacyclic Schisandraceae bisnortriterpenoid featuring a tetrasubstituted arene moiety. The left-hand fragment was accessed through a chiral-poo
Asymmetric Synthesis of Multisubstituted Dihydrobenzofurans by Intramolecular Conjugate Addition of Short-Lived C-O Axially Chiral Enolates (Special Section : Celebrating Professor Satoshi Omura's 2015 Nobel Prize in Physiology or Medicine)
Chemical and pharmaceutical bulletin 64(7), 899-906, 2016-07
Regio- and stereoselective multisubstituted olefin synthesis via hydro/carboalumination of alkynes and subsequent iron-catalysed cross-coupling reaction with alkyl halides