WordNet
- any malignant tumor derived from epithelial tissue; one of the four major types of cancer
PrepTutorEJDIC
- がん,がん腫
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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/01/27 12:49:12」(JST)
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| Mucoepidermoid carcinoma |
| Classification and external resources |
Micrograph of a mucoepidermoid carcinoma. FNA specimen. Pap stain. |
| ICD-O: |
M8430/3 |
| OMIM |
607536 |
| MeSH |
C04.557.470.200.025.340 |
Mucoepidermoid carcinoma is the most common type of salivary gland malignancy in adults. Mucoepidermoid carcinoma can also be found in other organs, as bronchi, lacrimal sac [1] and thyroid.
Mucicarmine staining is one stain used by pathologist for detection.[2]
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Contents
- 1 Epidemiology
- 2 Clinical Features
- 3 Histology
- 4 Molecular biology
- 5 Prognosis
- 6 Additional images
- 7 References
- 8 External links
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Epidemiology
Occurs in adults, with peak incidence from 20–40 years of age. A causal link with cytomegalovirus (CMV) has been strongly implicated in a 2011 research.[3]
Clinical Features
Presents as painless, slow-growing mass that is firm or hard. Most appear clinically as mixed tumors.
Histology
This tumor is not encapsulated and is characterized by squamous cells, mucus-secreting cells, and intermediate cells.
Molecular biology
Mucoepidermoid carcinomas of the salivary and bronchial glands are characterized by a recurrent t(11;19)(q21;p13) chromosomal translocation resulting in a MECT1-MAML2 fusion gene. The CREB-binding domain of the CREB coactivator MECT1 (also known as CRTC1, TORC1 or WAMTP1) is fused to the transactivation domain of the Notch coactivator MAML2 PMID 16444749.
A possible association with papillomavirus has been reported.[4]
Prognosis
Generally, there is a good prognosis for low-grade tumors, and a poor prognosis for high-grade tumors.
Additional images
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Histopathologic image of mucoepidermoid carcinoma of the major salivary gland. H & E stain.
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Histopathologic image of mucoepidermoid carcinoma of the major salivary gland. The same lesion as shown in a filename "Mucoepidermoid carcinoma (2) HE stain.jpg". H & E stain.
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Histopathologic image of mucoepidermoid carcinoma. Postoperative recurrence of the submandibular tumor. Alcian blue-PAS stain.
References
- ^ Elsevier Article Locator
- ^ Modern Pathology - Primary Mucoepidermoid Carcinoma and Sclerosing Mucoepidermoid Carcinoma with Eosinophilia of the Thyroid Gland: A Report of Nine Cases
- ^ Melnick M., Sedghizadeh P. P., Allen C. M., Jaskoll T. (10 November 2011). Experimental and Molecular Pathology 92 (1): 118–25. doi:10.1016/j.yexmp.2011.10.011. PMID 22101257. http://www.sciencedirect.com/science/article/pii/S0014480011001869.
- ^ Isayeva T, Said-Al-Naief N, Ren Z, Li R, Gnepp D, Brandwein-Gensler M (2012) Salivary mucoepidermoid carcinoma: Demonstration of transcriptionally active human papillomavirus 16/18. Head Neck Pathol
External links
- -489684982 at GPnotebook
- Overview at usc.edu
- Slide at jhu.edu
- mucoepidermoid carcinoma at humpath.com
- salivary mucoepidermoid carcinoma images at humpath.com
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Glandular and epithelial neoplasms (ICD-O 8010-8589)
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|
| Epithelium |
Papilloma/carcinoma
(8010-8139) |
- Small cell carcinoma
- Combined small cell carcinoma
- Verrucous carcinoma
- Squamous cell carcinoma
- Basal cell carcinoma
- Transitional cell carcinoma
- Inverted papilloma
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|
|
| Glands |
Adenomas/
adenocarcinomas
(8140-8429) |
| Gastrointestinal |
- tract: Linitis plastica
- Familial adenomatous polyposis
- pancreas
- Insulinoma
- Glucagonoma
- Gastrinoma
- VIPoma
- Somatostatinoma
- Cholangiocarcinoma
- Klatskin tumor
- Hepatocellular adenoma/Hepatocellular carcinoma
|
|
| Urogenital |
- Renal cell carcinoma
- Endometrioid tumor
- Renal oncocytoma
|
|
| Endocrine |
- Prolactinoma
- Multiple endocrine neoplasia
- Adrenocortical adenoma/Adrenocortical carcinoma
- Hurthle cell
|
|
| Other/multiple |
- Neuroendocrine tumor
- Adenoid cystic carcinoma
- Oncocytoma
- Clear cell adenocarcinoma
- Apudoma
- Cylindroma
- Papillary hidradenoma
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|
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Adnexal and
skin appendage (8390-8429) |
- sweat gland
- Syringocystadenoma papilliferum
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Cystic, mucinous,
and serous (8440-8499) |
| Cystic general |
- Cystadenoma/Cystadenocarcinoma
|
|
| Mucinous |
- Signet ring cell carcinoma
- Mucinous cystadenoma / Mucinous cystadenocarcinoma
- Mucoepidermoid carcinoma
|
|
| Serous |
- Ovarian serous cystadenoma / Pancreatic serous cystadenoma / Serous cystadenocarcinoma / Papillary serous cystadenocarcinoma
|
|
|
Ductal, lobular,
and medullary (8500-8549) |
| Ductal carcinoma |
- Mammary ductal carcinoma
- Pancreatic ductal carcinoma
- Comedocarcinoma
- Paget's disease of the breast / Extramammary Paget's disease
|
|
| Lobular carcinoma |
- Lobular carcinoma in situ
- Invasive lobular carcinoma
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| Medullary carcinoma |
- Medullary carcinoma of the breast
- Medullary thyroid cancer
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| Acinar cell (8550-8559) |
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| Other |
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| Complex epithelial (8560-8589) |
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- See also
- Template:Epithelium and epithelial tissue
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|
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Tumors of lip, oral cavity and pharynx / head and neck cancer (C00–C14/D10–D11, 140–149/210)
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| Oral cancer |
|
Salivary gland
|
malignant epithelial tumors (Acinic cell carcinoma, Mucoepidermoid carcinoma, Adenoid cystic carcinoma, Salivary duct carcinoma, Epithelial-myoepithelial carcinoma, Polymorphous low-grade adenocarcinoma, Hyalinizing clear cell carcinoma)
benign epithelial tumors (Pleomorphic adenoma, Warthin's tumor)
ungrouped: Oncocytoma
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Tongue
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Leukoplakia · Rhabdomyoma
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|
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Oropharynx
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|
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noco/cofa (c)/cogi/tumr, sysi
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UpToDate Contents
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English Journal
- Salivary gland carcinomas of the larynx: a national study in Denmark.
- Nielsen TK, Bjørndal K, Krogdahl A, Primdahl H, Kristensen CA, Andersen E, Godballe C.SourceDepartment of ENT Head and Neck Surgery, Odense University Hospital, Odense, Denmark. doctortroels@gmail.com
- Auris, nasus, larynx.Auris Nasus Larynx.2012 Dec;39(6):611-4. Epub 2012 Mar 15.
- OBJECTIVE: Salivary gland carcinomas of the larynx are rare. The purpose of this study is to present a national series of laryngeal salivary gland carcinoma patients and to bring a review of recent literature.METHODS: By merging The Danish Cancer Registry, The National Pathology Registry and The Nat
- PMID 22424720
- Clinicopathological Significance of MAML2 Gene Split in Mucoepidermoid Carcinoma.
- Noda H, Okumura Y, Nakayama T, Miyabe S, Fujiyoshi Y, Hattori H, Shimozato K, Inagaki H.SourceDepartment of Anatomic Pathology and Molecular Diagnostics, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan; Department of Maxillofacial Surgery, Aichi-Gakuin University School of Dentistry, Nagoya, Japan.
- Cancer science.Cancer Sci.2012 Oct 5. doi: 10.1111/cas.12039. [Epub ahead of print]
- CRTC1-MAML2 and CRTC3-MAML2 fusions have been associated with favorable clinicopathological features of mucoepidermoid carcinoma. However, significance of MAML2 gene split has not been fully clarified. Ninety-five mucoepidermoid carcinomas (paraffin-embedded materials) were analyzed for CRTC1-MAML2
- PMID 23035786
Japanese Journal
- 非ホジキンリンパ腫の完全寛解後に口蓋粘表皮癌を発症した異時性重複癌の1例
- 杉山 円,森 良之,末永 英之 [他]
- 日本口腔外科学会雑誌 = Japanese journal of oral and maxillofacial surgery 61(4), 222-226, 2015-04
- NAID 40020460841
- 高橋 健二郎,久下 亨,堀内 彦之,石川 博人,平川 浩明,中山 剛一,赤司 昌謙,中山 正道,奥田 康二,赤木 由人
- 膵臓 30(2), 243-249, 2015
- … 一部脾静脈および左Gerota筋膜への浸潤が疑われた．膵尾部悪性腫瘍の診断で，膵体尾部切除＋脾臓摘出術＋左Gerota筋膜部分切除＋左副腎切除＋D2リンパ節郭清を施行した．病理では粘表皮癌（mucoepidermoid carcinoma）成分，低分化腺癌および一部角化を伴う敷石状の扁平上皮癌成分が混在しており，WHO2010分類に基づいて腺扁平上皮癌，pT4N1M0 pStage IVaと診断した.術後4日目の腹部造影CTで，新たに肝S4，S5に …
- NAID 130005068118
Related Links
- Mucoepidermoid Carcinoma Mucoepidermoid carcinomas represent a distinct type of tumor. They contain three cellular elements in varying proportions: squamous cells, mucus-secreting cells, and "intermediate" cells. (1 ...
- Mucoepidermoid carcinoma is the most common type of salivary gland malignancy in adults. Mucoepidermoid carcinoma can also be found in other organs, as bronchi, lacrimal sac [1] and thyroid. Mucicarmine staining is one stain ...
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