English Journal

Effect of oxidative stress on Rho kinase II and smooth muscle contraction in rat stomach.

Al-Shboul O1, Mustafa A.
Canadian journal of physiology and pharmacology.Can J Physiol Pharmacol.2015 Jun;93(6):405-11. doi: 10.1139/cjpp-2014-0505. Epub 2015 Jan 28.
Recent studies have shown that both Rho kinase signaling and oxidative stress are involved in the pathogenesis of a number of human diseases, such as diabetes mellitus, hypertension, and atherosclerosis. However, very little is known about the effect of oxidative stress on the gastrointestinal (GI)
PMID 25752964

Profiling and relative quantification of multiply nitrated and oxidized fatty acids.

Milic I1, Griesser E, Vemula V, Ieda N, Nakagawa H, Miyata N, Galano JM, Oger C, Durand T, Fedorova M.
Analytical and bioanalytical chemistry.Anal Bioanal Chem.2015 May 29. [Epub ahead of print]
The levels of nitro fatty acids (NO2-FA), such as nitroarachidonic, nitrolinoleic, nitrooleic, and dinitrooleic acids, are elevated under various inflammatory conditions, and this results in different anti-inflammatory effects. However, other multiply nitrated and nitro-oxidized FAs have not been st
PMID 26022093

Szuba A1, Kasprowicz-Maluśki A2, Wojtaszek P3.
Journal of proteomics.J Proteomics.2015 Apr 29;120:158-68. doi: 10.1016/j.jprot.2015.03.002. Epub 2015 Mar 21.
Nitric oxide causes numerous protein modifications including nitration of tyrosine residues. This modification, though one of the greatest biological importance, is poorly recognized in plants and is usually associated with stress conditions. In this study we analyzed nitrotyrosines from suspension
PMID 25805245

Japanese Journal

Neoechinulin A Imparts Resistance to Acute Nitrosative Stress in PC12 Cells: A Potential Link of an Elevated Cellular Reserve Capacity for Pyridine Nucleotide Redox Turnover with Cytoprotection

Akashi Soichiro,Shirai Kyo,Okada Tatsumi [他],Konishi Kanako,Takeuchi Toshifumi,Kuramochi Kouji,Takahashi Muneaki,Nakagawa Tomoya,Ogura Yuki,Fujieda Satoshi,Shibata Yasushi,Sugawara Fumio,Kobayashi Susumu,Watanabe Nobuo,Arai Takao
Biological and Pharmaceutical Bulletin 35(7), 1105-1117, 2012
… Treatment of PC12 cells with fungus-derived alkaloid neoechinulin A for more than 12 h renders the cells resistant to subsequent superoxide (O2−)/nitric oxide (NO) insults derived from 3-morpholinosydnonimine (SIN-1). …
NAID 130001872114

Geniposide Induces the Expression of Heme Oxygenase-1 via PI3K/Nrf2-Signaling to Enhance the Antioxidant Capacity in Primary Hippocampal Neurons

Yin Fei,Liu Jianhui,Zheng Xuxu [他],Guo Lixia,Xiao He
Biological and Pharmaceutical Bulletin 33(11), 1841-1846, 2010
… In this study, geniposide upregulates the expression of heme oxygenase-1 (HO-1) to attenuate the cell apoptosis induced by 3-morpholinosydnonimine hydrochloride (SIN-1) in primary cultured hippocampal neurons. …
NAID 130000402305

Inhibitory Effects of Nitrative Stress on the Sulfation of 17.BETA.-Estradiol and 4-Methoxyestradiol by Human MCF 10A Mammary Epithelial Cells

Hui Ying,Yasuda Tomoko,Yasuda Shin [他],Liu Ming-Yih,Sakakibara Yoichi,Suiko Masahito,Wall Katherine Ann,Liu Ming-Cheh
Biological and Pharmaceutical Bulletin 33(9), 1633-1637, 2010
… Metabolic labeling experiments revealed that the amount of sulfated 17β-estradiol or 4-methoxyestradiol decreased dramatically in MCF-10A mammary epithelial cells incubated in the presence of 3-morpholinosydnonimine (SIN-1) or diethylenetriamine NONOate (DETA NONOate), two nitric oxide donors commonly used to simulate nitrative stress conditions. …
NAID 130000322369