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Moracizine^[1] or moricizine and sold under the trade name Ethmozine, is an antiarrhythmic of class IC.^[2] It was used for the prophylaxis and treatment of serious and life-threatening ventricular arrhythmias,^[3] but was withdrawn in 2007 for commercial reasons.^[4]

Pharmacology

Moracizine, a phenothiazine derivative, undergoes extensive first-pass metabolism and is also extensively metabolized after it has entered the circulation. It may have pharmacologically active metabolites. A clinical study has shown that moracizine is slightly less effective than encainide or flecainide in suppressing ventricular premature depolarizations.^{[citation needed]} Compared with disopyramide and quinidine, moracizine was equally or more effective in suppressing premature ventricular contractions, couplets, and nonsustained ventricular tachycardia.^{[citation needed]}

In the Cardiac Arrhythmia Suppression Trial (CAST), a large study testing the influence of antiarrhythmics on mortality, showed a statistically non-significant increase of mortality from 5.4 to 7.2% under moracizine. This is in line with other class IC antiarrhythmics.^[5]

References

^ "The use of stems in the selection of International Nonproprietary Names (INN) for pharmaceutical substances" (PDF). World Health Organization. 2009. p. 103.
^ Ahmmed, G. U.; Hisatome, I.; Kurata, Y.; Makita, N.; Tanaka, Y.; Tanaka, H.; Okamura, T.; Sonoyama, K.; Furuse, Y.; Kato, M.; Yamamoto, Y.; Ogura, K.; Shimoyama, M.; Miake, J.; Sasaki, N.; Ogino, K.; Igawa, O.; Yoshida, A.; Shigemasa, C. (2002). "Analysis of moricizine block of sodium current in isolated guinea-pig atrial myocytes. Atrioventricular difference of moricizine block". Vascular pharmacology. 38 (3): 131–141. doi:10.1016/S1537-1891(02)00213-6. PMID 12402511.
^ British National Formulary (59th ed.). British Medical Journal Publishing Group, Pharmaceutical Press. 2010.
^ "Shire Announces Ethmozine will be Available until December 31, 2007". Heart Rhythm Society.
^ Cardiac Arrhythmia Suppression Trial II Investigators (1992). "Effect of the Antiarrhythmic Agent Moricizine on Survival after Myocardial Infarction". New England Journal of Medicine. 327 (4): 227–233. doi:10.1056/NEJM199207233270403. PMID 1377359.

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UpToDate Contents

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1. 非持続性心室頻拍のマネージメント management of nonsustained ventricular tachycardia
2. 心房細動患者における洞調律維持のための抗不整脈薬：臨床試験 antiarrhythmic drugs to maintain sinus rhythm in patients with atrial fibrillation clinical trials
3. 小児における心房頻拍 atrial tachycardias in children
4. 心筋梗塞後の患者における心室性不整脈に対する抗不整脈剤の役割 role of antiarrhythmic drugs for ventricular arrhythmias in patients with a prior myocardial infarction
5. 突然の心停止における心理社会的要因 psychosocial factors in sudden cardiac arrest

English Journal

[Appearance of ECG signs of the Brugada syndrome during therapy with class 1C antiarrhythmic drug ethacizine].

Makarov LM, Komoliatova VN.
Kardiologiia.Kardiologiia.2011;51(4):93-5.
PMID 21623727

[The role of reflexotherapy and physical training in the combined treatment and the prevention of paroxysmal form of idiopathic atrial fibrillation].

Kobel'kov SN, Lebedeva OD.
Voprosy kurortologii, fizioterapii, i lechebnoĭ fizicheskoĭ kultury.Vopr Kurortol Fizioter Lech Fiz Kult.2008 Nov-Dec;(6):36-8.
PMID 19175054

Effect of drugs on defibrillation capacity.

Dopp AL1, Miller JM, Tisdale JE.
Drugs.Drugs.2008;68(5):607-30.
Over 300,000 people die of sudden cardiac death (SCD) in the US annually. Implantable cardioverter-defibrillators (ICDs) have been shown to be more effective than antiarrhythmic drugs for the prevention of SCD in specific susceptible populations. Many patients in whom ICDs have been implanted receiv
PMID 18370441

Japanese Journal

P527 組織特異性を有さないClass 1c群抗不整脈剤MoricizineのNa channel a subunit抑制作用

Japanese circulation journal 63(supple1), 581, 1999-03-01
NAID 110002574881

Moricizine と N-acetylprocainamide における心房粗動の停止および再誘発の機序無菌性心膜炎犬を用いて

東邦醫學會雜誌 = Journal of the Medical Society of Toho University 42(2), 126-139, 1995-07-01
NAID 10012227450

Simultaneous determination of moricizine and its sulphoxidation metabolites in biological fluids by high-performance liquid chromatography

Journal of chromatography. B, Biomedical applications 663(1), 172-176, 1995-01-06
NAID 10024543623

Related Pictures

File:Moricizine.png - Wikimedia Commons Moricizine; en 313; en-313; en313 Moricizine Hydrochloride, chemical of the Antiarrhythmic Agent Moricizine Heterocyclic compounds (3 rings) Category:Phenothiazines - Wikimedia File:Moricizine synthesis.png - Wikimedia

★リンクテーブル★

リンク元	「モリシジン」「moracizine」
拡張検索	「moricizine hydrochloride」

「モリシジン」

Moracizine
Clinical data
Trade names	Ethmozine
Synonyms	Moricizine (USAN US)
AHFS/Drugs.com	Consumer Drug Information
MedlinePlus	a601214
Pregnancy; category	B (U.S.);
ATC code	C01BG01 (WHO);
Pharmacokinetic data
Bioavailability	34–38%
Protein binding	95%
Biological half-life	3–4 hours (healthy volunteers), 6–13 hours (cardiac disease)
Identifiers
	IUPAC name ethyl [10-(3-morpholin-4-ylpropanoyl)-10H-phenothiazin-2-yl]carbamate;
CAS Number	31883-05-3 ;
PubChem CID	34633;
IUPHAR/BPS	7244;
DrugBank	DB00680 ;
ChemSpider	31872 ;
UNII	2GT1D0TMX1;
KEGG	D05077 ;
ChEBI	CHEBI:6997 ;
ChEMBL	CHEMBL1075 ;
ECHA InfoCard	100.046.216
Chemical and physical data
Formula	C22H25N3O4S
Molar mass	427.518 g/mol
3D model (JSmol)	Interactive image;
	SMILES O=C(OCC)Nc2cc1N(c3c(Sc1cc2)cccc3)C(=O)CCN4CCOCC4 ;
	InChI InChI=1S/C22H25N3O4S/c1-2-29-22(27)23-16-7-8-20-18(15-16)25(17-5-3-4-6-19(17)30-20)21(26)9-10-24-11-13-28-14-12-24/h3-8,15H,2,9-14H2,1H3,(H,23,27) ; Key:FUBVWMNBEHXPSU-UHFFFAOYSA-N ;
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