モペロン
- 関
- methylperidol、moperone hydrochloride
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/04/11 13:26:34」(JST)
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Moperone
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| Names |
| IUPAC name
1-(4-fluorophenyl)-4-[4-hydroxy-4-(4-methylphenyl)piperidin-1-yl]butan-1-one
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| Identifiers |
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CAS Number
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3D model (Jmol)
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| ChemSpider |
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| ECHA InfoCard |
100.012.625 |
| EC Number |
223-392-7 |
| KEGG |
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| UNII |
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InChI
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InChI=1S/C22H26FNO2/c1-17-4-8-19(9-5-17)22(26)12-15-24(16-13-22)14-2-3-21(25)18-6-10-20(23)11-7-18/h4-11,26H,2-3,12-16H2,1H3 N
Key: AGAHNABIDCTLHW-UHFFFAOYSA-N N
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InChI=1/C22H26FNO2/c1-17-4-8-19(9-5-17)22(26)12-15-24(16-13-22)14-2-3-21(25)18-6-10-20(23)11-7-18/h4-11,26H,2-3,12-16H2,1H3
Key: AGAHNABIDCTLHW-UHFFFAOYAM
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SMILES
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CC1=CC=C(C=C1)C2(CCN(CC2)CCCC(=O)C3=CC=C(C=C3)F)O
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| Properties |
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Chemical formula
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C22H26FNO2 |
| Molar mass |
355.445743 g/mol |
| Pharmacology |
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ATC code
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N05AD04 (WHO) |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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| N verify (what is YN ?) |
| Infobox references |
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Moperone (Luvatren, since discontinued) is a typical antipsychotic of the butyrophenone class.[1]
References
- ^ Gross, H; Kaltenbäck, E (1969). "The clinical position of moperone among the butyrophenones". Nordisk psykiatrisk tidsskrift. Nordic Journal of Psychiatry. 23 (1): 4–9. PMID 5354545.
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Antipsychotics (neuroleptics) (N05A)
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| Typical |
- Benzamides
- Levosulpiride
- Sulpiride
- Veralipride‡
- Butyrophenones
- Azaperone
- Benperidol
- Bromperidol
- Droperidol
- Fluanisone
- Haloperidol#
- Lenperone
- Moperone
- Pipamperone
- Spiperone
- Timiperone
- Trifluperidol
- Diphenylbutylpiperidines
- Clopimozide
- Fluspirilene
- Penfluridol
- Pimozide
- Phenothiazines
- Acepromazine
- Acetophenazine
- Butaperazine
- Carphenazine (carfenazine)
- Chloracizine
- Chlorproethazine
- Chlorpromazine
- Cyamemazine
- Dixyrazine
- Fluacizine
- Fluphenazine
- Levomepromazine/Methotrimeprazine
- Mesoridazine
- Perazine
- Periciazine
- Perphenazine
- Perphenazine 4-aminobutyrate
- Piperacetazine
- Pipotiazine
- Prochlorperazine
- Promazine
- Promethazine
- Sulforidazine
- Thiethylperazine
- Thiopropazate
- Thioproperazine
- Thioridazine
- Trifluoperazine
- Triflupromazine
- Thioxanthenes
- Chlorprothixene
- Clopenthixol
- Clothixamide
- Flupentixol
- Fluprothixene
- Piflutixol
- Teflutixol
- Thiothixene
- Zuclopenthixol
- Tricyclics
- Fluotracen
- Loxapine
- Trimipramine
- Others
- Butaclamol
- Prothipendyl
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| Atypical |
- Benzamides
- Amisulpride
- Nemonapride
- Remoxipride‡
- Sultopride
- Tiapride
- Butyrophenones
- Cinuperone
- Melperone
- Setoperone
- Benzo(iso)oxazolepiperidines
- Iloperidone
- Ocaperidone§
- Paliperidone
- Risperidone#
- Benzo(iso)thiazolepiperazines
- Lurasidone
- Perospirone
- Revospirone§
- Tiospirone§
- Ziprasidone
- Diphenylbutylpiperazines
- Amperozide
- Phenylpiperazines
- Aripiprazole
- Aripiprazole lauroxil
- Bifeprunox§
- Brexpiprazole
- Cariprazine
- Tricyclics
- Amoxapine
- Asenapine
- Carpipramine
- Clocapramine
- Clorotepine
- Clotiapine
- Clozapine#
- Flumezapine
- Fluperlapine
- Gevotroline
- Metitepine
- Mosapramine
- Olanzapine
- Quetiapine
- Tenilapine
- Zotepine
- Others
- Blonanserin
- Lumateperone†
- Molindone
- Pimavanserin
- RP5063†
- Sertindole
- Zicronapine§
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| Others |
- Azacyclonol
- Cannabidiol
- Oxypertine
- Reserpine
- Tetrabenazine
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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English Journal
- Automated on-line in-tube solid-phase microextraction coupled with HPLC/MS/MS for the determination of butyrophenone derivatives in human plasma.
- Kumazawa T1, Saeki K, Yanagisawa I, Uchigasaki S, Hasegawa C, Seno H, Suzuki O, Sato K.
- Analytical and bioanalytical chemistry.Anal Bioanal Chem.2009 Jun;394(4):1161-70. doi: 10.1007/s00216-009-2774-0. Epub 2009 Apr 23.
- This paper describes a fully automated on-line method combining in-tube solid-phase microextraction (SPME) in which sample clean-up and enrichment are conducted through an open tubular fused-silica capillary column and high-performance liquid chromatography (HPLC)/tandem mass spectrometry (MS/MS) de
- PMID 19387622
- Atypical properties of several classes of antipsychotic drugs on the basis of differential induction of Fos-like immunoreactivity in the rat brain.
- Oka T1, Hamamura T, Lee Y, Miyata S, Habara T, Endo S, Taoka H, Kuroda S.
- Life sciences.Life Sci.2004 Nov 26;76(2):225-37.
- Acute administration of typical and atypical antipsychotics has been reported to induce regionally distinct patterns of c-Fos expression in the rat forebrain. Furthermore, atypical index, the difference in the extent of increased Fos-like immunoreactivity (Fos-LI) in the nucleus accumbens (NAc) shel
- PMID 15519367
- High-performance liquid chromatographic determination of fluvoxamine and fluvoxamino acid in human plasma.
- Ohkubo T1, Shimoyama R, Otani K, Yoshida K, Higuchi H, Shimizu T.
- Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.Anal Sci.2003 Jun;19(6):859-64.
- A high-performance liquid chromatographic (HPLC) method has been developed for the simultaneous determination of fluvoxamine and its major metabolite fluvoxamino acid in plasma. Fluvoxamine and fluvoxamino acid in plasma were extracted using a C18 bonded-solid phase cartridge, followed by C4 reverse
- PMID 12834224
Japanese Journal
- ポリマーカラムを用いた全血中ブチロフェノン系薬物のLC/MS/MS分析
- High-Performance Liquid Chromatographic Determination of Fluvoxamine and Fluvoxamino Acid in Human Plasma
- ウサギ腎由来のカルボニル還元酵素により触媒されるアセトヘキサミドの還元反応におけるケトン性薬物の抑制効果に関する研究
- 福山大学薬学部研究年報 = Annual report of the Faculty of Pharmacy & Pharmaceutical Sciences, Fukuyama University 16, 56-57, 1998
- NAID 120005499681
Related Links
- ^Gross, H; Kaltenbäck, E (1969). "The clinical position of moperone among the butyrophenones". Nordisk psykiatrisk tidsskrift. Nordic journal of psychiatry 23 (1): 4–9. PMID 5354545.
- Moperone is a medicine available in a number of countries worldwide. A list of US medications equivalent to Moperone is available on the Drugs.com website. ... Drugs.com provides accurate and independent information on more than ...
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- 英
- moperone、methylperidol、moperone hydrochloride
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- 塩酸モペロン
-moperone
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モペロン
- 関
- moperone、moperone hydrochloride
[★]
- 関
- methylperidol、moperone