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English Journal

Comparative Safety of Vaccine Adjuvants: A Summary of Current Evidence and Future Needs.

Petrovsky N1,2.
Drug safety.Drug Saf.2015 Nov;38(11):1059-74. doi: 10.1007/s40264-015-0350-4.
Use of highly pure antigens to improve vaccine safety has led to reduced vaccine immunogenicity and efficacy. This has led to the need to use adjuvants to improve vaccine immunogenicity. The ideal adjuvant should maximize vaccine immunogenicity without compromising tolerability or safety. Unfortunat
PMID 26446142

Short- and long-term regulation of intestinal Na+/H+ exchange by Toll-like receptors TLR4 and TLR5.

Cabral JM1, Grácio D1, Soares-da-Silva P2, Magro F3.
American journal of physiology. Gastrointestinal and liver physiology.Am J Physiol Gastrointest Liver Physiol.2015 Oct 15;309(8):G703-15. doi: 10.1152/ajpgi.00124.2015. Epub 2015 Aug 20.
Inappropriate activation of pattern recognition receptors has been described as a potential trigger in the development of inflammatory bowel disease (IBD). In this study, we evaluated the activity and expression of Na(+)/H(+) exchanger (NHE) subtypes in T84 intestinal epithelial cells during Toll-li
PMID 26294670

Design and evaluation of surface and adjuvant modified PLGA microspheres for uptake by dendritic cells to improve vaccine responses.

Salvador A1, Sandgren KJ2, Liang F3, Thompson EA3, Koup RA4, Pedraz JL1, Hernández RM1, Loré K5, Igartua M6.
International journal of pharmaceutics.Int J Pharm.2015 Oct 14. pii: S0378-5173(15)30303-3. doi: 10.1016/j.ijpharm.2015.10.037. [Epub ahead of print]
Designing strategies for targeting antigens to dendritic cells is a major goal in vaccinology. Here, PLGA (poly lactic-co-glycolic acid) microspheres and with several surface modifications that affect to their uptake by human blood primary dendritic cells and monocytes have been evaluated. Higher up
PMID 26475970