mofezolac

モフェゾラク

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/06 17:24:52」(JST)

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Mofezolac

Systematic (IUPAC) name
[3,4-bis(4-methoxyphenyl)isoxazol-5-yl]acetic acid
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	℞ Prescription only
Routes	Oral
Identifiers
CAS number	78967-07-4 Y
ATC code	None
PubChem	CID 4237
UNII	RVJ0BV3H3Y Y
KEGG	D01718 Y
Chemical data
Formula	C19H17NO5
Mol. mass	339.34 g/mol
SMILES COC1=CC=C(C=C1)C2=C(ON=C2C3=CC=C(C=C3)OC)CC(=O)O
Y (what is this?)  (verify)

Mofezolac (INN) is a non-steroidal anti-inflammatory drug.

English Journal

• Chemopreventive effect of mofezolac on beef tallow diet/azoxymethane-induced colon carcinogenesis in rats.

• Miao L, Shiraishi R, Fujise T, Kuroki T, Kakimoto T, Sakata Y, Takashima T, Iwakiri R, Fujimoto K, Shi R, Li X.SourceDepartment of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan.
• Hepato-gastroenterology.Hepatogastroenterology.2011 Jan-Feb;58(105):81-8.
• BACKGROUND/AIMS: We have previously shown that long-term consumption of 10% beef tallow diet promotes colon carcinogenesis in both saline- and azoxymethane (AOM)-treated rats. Here, we investigated the effects of mofezolac, a selective COX-1 inhibitor, on beef tallow-fed rats with saline- or AOM tre
• PMID 21510291

• Selective COX-1 inhibition: A therapeutic target to be reconsidered.

• Perrone MG, Scilimati A, Simone L, Vitale P.SourceDepartment of Medicinal Chemistry, University of Bari A. Moro, Via Orabona 4, 70125 (Bari), Italy.
• Current medicinal chemistry.Curr Med Chem.2010;17(32):3769-805.
• Since cyclooxygenase (COX) isozymes discovery, many papers and reviews have been published to describe the structural bases of COX inhibition, and to debate on the therapeutic and adverse effects of worldwide clinically used nonsteroidal anti-inflammatory drugs (NSAIDs), included COX-2 selective inh
• PMID 20858219

Japanese Journal

• Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac

• NIHO Naoko,KITAMURA Tomohiro,TAKAHASHI Mami,MUTOH Michihiro,SATO Hidetaka,MATSUURA Mamoru,SUGIMURA Takashi,WAKABAYASHI Keiji
• Cancer science 97(10), 1011-1014, 2006-10-10
• NAID 10019377864

• Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis

• KITAMURA T
• Carcinogenesis 23, 1463-1466, 2002
• NAID 30018393519

Related Links

• モフェゾラク（Mofezolac）に関連する治療薬－処方薬検索ならQLife

モフェゾラク（Mofezolac）の検索ならお薬検索QLife（キューライフ）。お医者さんが処方する処方薬と、薬局で買える市販薬(OTC)、の効果と副作用、写真、添付文書、保管方法等を掲載。商品名だけでなく一般名や剤形、色など ...

• Mofezolac : CAS 78967-07-4

前へ戻る 入力へ戻る 化学物質の情報サイトのリンク集 （Mofezolac） 物質名 ; Mofezolac; モフェゾラク ＊＊個々の物質名をクリックするとGoogleで検索します。＊＊ 情報掲示板 :発言はありません。 CASボタンを押すと ...

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非ステロイド性抗炎症薬