mofezolac

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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/02/06 17:24:52」(JST)

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English Journal

  • Chemopreventive effect of mofezolac on beef tallow diet/azoxymethane-induced colon carcinogenesis in rats.
  • Miao L, Shiraishi R, Fujise T, Kuroki T, Kakimoto T, Sakata Y, Takashima T, Iwakiri R, Fujimoto K, Shi R, Li X.SourceDepartment of Internal Medicine and Gastrointestinal Endoscopy, Saga Medical School, 5-1-1 Nabeshima, Saga 849-8501, Japan.
  • Hepato-gastroenterology.Hepatogastroenterology.2011 Jan-Feb;58(105):81-8.
  • BACKGROUND/AIMS: We have previously shown that long-term consumption of 10% beef tallow diet promotes colon carcinogenesis in both saline- and azoxymethane (AOM)-treated rats. Here, we investigated the effects of mofezolac, a selective COX-1 inhibitor, on beef tallow-fed rats with saline- or AOM tre
  • PMID 21510291
  • Selective COX-1 inhibition: A therapeutic target to be reconsidered.
  • Perrone MG, Scilimati A, Simone L, Vitale P.SourceDepartment of Medicinal Chemistry, University of Bari A. Moro, Via Orabona 4, 70125 (Bari), Italy.
  • Current medicinal chemistry.Curr Med Chem.2010;17(32):3769-805.
  • Since cyclooxygenase (COX) isozymes discovery, many papers and reviews have been published to describe the structural bases of COX inhibition, and to debate on the therapeutic and adverse effects of worldwide clinically used nonsteroidal anti-inflammatory drugs (NSAIDs), included COX-2 selective inh
  • PMID 20858219

Japanese Journal

  • Suppression of azoxymethane-induced colon cancer development in rats by a cyclooxygenase-1 selective inhibitor, mofezolac
  • NIHO Naoko,KITAMURA Tomohiro,TAKAHASHI Mami,MUTOH Michihiro,SATO Hidetaka,MATSUURA Mamoru,SUGIMURA Takashi,WAKABAYASHI Keiji
  • Cancer science 97(10), 1011-1014, 2006-10-10
  • NAID 10019377864
  • Inhibitory effects of mofezolac, a cyclooxygenase-1 selective inhibitor, on intestinal carcinogenesis

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mofezolac
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非ステロイド性抗炎症薬