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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/01/09 00:36:56」(JST)

Midecamycin is a macrolide antibiotic. Synthesized from Streptomyces mycarofaciens.

Physical Properties

Melting point vary depending on the compound type. It may also vary depending on the source consulted. Example:

For the A₁ type:

The Merck Index reports 155-156 Celsius. The Japanese Pharmacopoeia reports 153–158 Celsius.

For the A₃ type:

The Merck Index reports 122-125 Celsius.

Prevalence, toxin gene profiles, and antimicrobial resistance of Staphylococcus aureus isolated from quick-frozen dumplings.

Hao D1, Xing X2, Li G2, Wang X3, Zhang M2, Zhang W2, Xia X4, Meng J4.
Journal of food protection.J Food Prot.2015 Jan;78(1):218-23. doi: 10.4315/0362-028X.JFP-14-100.
The aim of this study was to investigate the prevalence of Staphylococcus aureus in quick-frozen dumplings and to characterize these strains. A total of 120 dumpling samples, including lamb (n = 13), vegetarian (n = 14), seafood (n = 12), and pork (n = 81) stuffing, were collected in Shaanxi provinc
PMID 25581200

[Expression of 4"-O-isovaleryltransferase gene from Streptomyces thermotolerans in Streptomyces lividans TK24].

Zhang J, Zhong J, Dai J, Wang Y, Xia H, He W.
Sheng wu gong cheng xue bao = Chinese journal of biotechnology.Sheng Wu Gong Cheng Xue Bao.2014 Sep;30(9):1390-400.
4"-O-isovaleryltransferase gene (ist) was regulated by positive regulatory genes of midecamycin 4"-O-propionyltransferase gene (mpt) in Streptomyces lividans TK24. A BamH I ~8.0 kb fragment from Streptomyces mycarofaciens 1748 was proved that it contained mpt gene and linked with two positive regula
PMID 25720154

Hydroxylation and hydrolysis: two main metabolic ways of spiramycin I in anaerobic digestion.

Zhu P1, Chen D2, Liu W2, Zhang J2, Shao L2, Li JA2, Chu J3.
Bioresource technology.Bioresour Technol.2014 Feb;153:95-100. doi: 10.1016/j.biortech.2013.11.073. Epub 2013 Dec 1.
The anaerobic degradation behaviors of five macrolides including spiramycin I, II, III, midecamycin and josamycin by sludge were investigated. Within 32days, 95% of spiramycin I, II or III was degraded, while the remove rate of midecamycin or josamycin was 75%. SPM I degradation was much higher in n
PMID 24345568

Determination of midecamycin by capillary zone electrophoresis with electrochemical detection

LIU Daxing,JIN Wenrui
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 783(2), 509-515, 2003-01-15
NAID 10012028889

Fujie Toshio,Yano Takako,Takahashi Noriaki,Tanikawa Satoshi,MASUTANI Masayuki,HORIE Takashi
肺癌 41(1), 11-19, 2001-02-20
… Methods:We chose clarithromycin(CAM) and midecamycin(MDM) as 14-and 16-membered ring macrolide antibiotics, respectively. …
NAID 110003117095

OKUBO YASUMITSU
Ｔｈｅ　Ｋｕｒｕｍｅ　Ｍｅｄｉｃａｌ　Ｊｏｕｒｎａｌ 44(2), 115-123, 1997
… We investigated the effect of some macrolides, erythromycin (EM), rokitamycin (RKM), midecamycin (MDM) on the expression of neutrophil adhesion molecule Mac-1 using LPS-stimulated human whole blood as an experimental vivo model. …
NAID 130000882856

リンク元	「ミデカマイシン」「MDM」
拡張検索	「midecamycin acetate」

Midecamycin
Systematic (IUPAC) name
	(2S,3S,4R,6S)-6-{[(2R,3S,4R,5R,6S)-4-(dimethylamino)-5-hydroxy-6-{[(4R,6S,7R,9R,10R,11E,13E,16R)-10-hydroxy-5-methoxy-9,16-dimethyl-2-oxo-7-(2-oxoethyl)-4-(propanoyloxy)-1-oxacyclohexadeca-11,13-dien-6-yl]oxy}-2-methyloxan-3-yl]oxy}-4-hydroxy-2,4-dimethyloxan-3-yl propanoate
Clinical data
AHFS/Drugs.com	International Drug Names
Legal status	?
Identifiers
CAS number	35457-80-8
ATC code	J01FA03
PubChem	CID 5382853
ChemSpider	4445365
UNII	N34Z0Y5UH7
KEGG	D01339
Chemical data
Formula	C41H67NO15
Molecular mass	813.968 g/mol
	SMILES O=CC[C@H]3C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@H](OC(=O)C[C@@H](OC(=O)CC)[C@H](OC)[C@H]3O[C@@H]2O[C@@H]([C@@H](O[C@@H]1O[C@H]([C@H](OC(=O)CC)[C@](O)(C1)C)C)[C@H](N(C)C)[C@H]2O)C)C;
	InChI InChI=1S/C41H67NO15/c1-11-30(45)54-29-21-32(47)51-24(4)16-14-13-15-17-28(44)23(3)20-27(18-19-43)37(38(29)50-10)57-40-35(48)34(42(8)9)36(25(5)53-40)56-33-22-41(7,49)39(26(6)52-33)55-31(46)12-2/h13-15,17,19,23-29,33-40,44,48-49H,11-12,16,18,20-22H2,1-10H3/b14-13+,17-15+/t23-,24-,25-,26+,27+,28+,29-,33+,34-,35-,36-,37+,38+,39+,40+,41-/m1/s1 ; Key:DMUAPQTXSSNEDD-QALJCMCCSA-N ;
Physical data
Melting point	155 to 156 °C (311 to 313 °F)
Solubility in water	Soluble in acidic/low pH water; Very soluble in methanol, chloroform, ethyl acetate, benzene, ethyl ether; Almost completely in ethanol(>95.5) mg/mL (20 °C)
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