Adaptive regulatory substitutions affect multiple stages in the life cycle of the bacteriophage φX174.
Brown CJ, Stancik AD, Roychoudhury P, Krone SM.SourceDepartment of Biological Sciences, University of Idaho, Moscow, ID 83844, USA. celesteb@uidaho.edu
BMC evolutionary biology.BMC Evol Biol.2013 Mar 18;13:66. doi: 10.1186/1471-2148-13-66.
BACKGROUND: Previously, we showed that adaptive substitutions in one of the three promoters of the bacteriophage φX174 improved fitness at high-temperature by decreasing transcript levels three- to four-fold. To understand how such an extreme change in gene expression might lead to an almost two-fo
Effects of an early conformational switch defect during ϕX174 morphogenesis are belatedly manifested late in the assembly pathway.
Gordon EB, Fane BA.SourceSchool of Plant Sciences and the BIO5 Institute, University of Arizona, Tucson, Arizona, USA.
Journal of virology.J Virol.2013 Mar;87(5):2518-25. doi: 10.1128/JVI.02839-12. Epub 2012 Dec 19.
C-terminal, aromatic amino acids in the ϕX174 internal scaffolding protein B mediate conformational switches in the viral coat protein. These switches direct the coat protein through early assembly. In addition to the aromatic amino acids, two acidic residues, D111 and E113, form salt bridges with
Improved virus removal in ceramic depth filters modified with MgO.
Michen B, Fritsch J, Aneziris C, Graule T.SourceLaboratory for High Performance Ceramics, EMPA, Swiss Federal Laboratories for Materials Science and Technology, Ueberlandstrasse 129, CH-8600 Duebendorf, Switzerland. b.michen@web.de
Environmental science & technology.Environ Sci Technol.2013 Feb 5;47(3):1526-33. doi: 10.1021/es303685a. Epub 2013 Jan 9.
Ceramic filters, working on the depth filtration principle, are known to improve drinking water quality by removing human pathogenic microorganisms from contaminated water. However, these microfilters show no sufficient barrier for viruses having diameters down to 20 nm. Recently, it was shown that
A knowledge resource to understand virus diversity ... VIRION Non-enveloped, round, T=1 icosahedral symmetry, about 30 nm in diameter. The capsid consists of 12 pentagonal trumpet-shaped pentomers. The virion is composed of ...
Species, Scientific Experts, Genomes and Genes, Publications, Research Topics about microvirus ... ..This study provides the greatest detail yet in combining fitness profiles with the underlying pattern of genetic changes, and the ...