UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 妊娠時の急性脂肪肝 acute fatty liver of pregnancy
2. アルコール性脂肪性肝炎およびアルコール性肝硬変の臨床症状および診断 clinical manifestations and diagnosis of alcoholic fatty liver disease and alcoholic cirrhosis
3. HIVヌクレオシド系逆転写酵素阻害剤のミトコンドリア毒性 mitochondrial toxicity of hiv nucleoside reverse transcriptase inhibitors
4. アルコール性脂肪性肝疾患およびアルコール性肝硬変の予後および治療 prognosis and management of alcoholic fatty liver disease and alcoholic cirrhosis
5. 肝生検標本の解釈 interpretation of liver biopsy specimens

English Journal

The serrated neoplasia pathway of colorectal tumors: Identification of MUC5AC hypomethylation as an early marker of polyps with malignant potential.

Renaud F1,2,3, Mariette C1,3,4, Vincent A1,3,5, Wacrenier A2, Maunoury V6, Leclerc J1,3,7, Coppin L1,3,7, Crépin M7, Van Seuningen I1,3,5, Leteurtre E1,2,3, Buisine MP1,3,7.
International journal of cancer. Journal international du cancer.Int J Cancer.2016 Mar 15;138(6):1472-81. doi: 10.1002/ijc.29891. Epub 2015 Oct 30.
The serrated neoplasia pathway accounts for 20-30% of colorectal cancers (CRC), which are characterized by extensive methylation (CpG island methylation phenotype, CIMP), frequent BRAF mutation and high microsatellite instability (MSI). We recently identified MUC5AC mucin gene hypomethylation as a s
PMID 26476272

The effect of ageing on isoniazid pharmacokinetics and hepatotoxicity in Fischer 344 rats.

Mach J1,2,3, Huizer-Pajkos A1,2, Mitchell SJ4, McKenzie C5, Phillips L6, Kane A1,2,3, Jones B3,7, de Cabo R4, Cogger V3,8, Le Couteur DG3,8, Hilmer SN1,2,3.
Fundamental & clinical pharmacology.Fundam Clin Pharmacol.2016 Feb;30(1):23-34. doi: 10.1111/fcp.12157. Epub 2015 Nov 9.
Isoniazid is the first-line treatment for tuberculosis; however, its use is limited by hepatotoxicity. Age-related differences in isoniazid pharmacokinetics and hepatotoxicity are uncertain. We aimed to investigate these in young (3 ± 0 months, n = 26) and old (23.0 ± 0.2 months, n = 27) male Fisc
PMID 26454000

Glucagon-like peptide-2 treatment improves glucose dysmetabolism in mice fed a high-fat diet.

Baldassano S1, Amato A1, Caldara GF1, Mulè F2.
Endocrine.Endocrine.2016 Jan 30. [Epub ahead of print]
Previous studies suggested that endogenous glucagon-like peptide 2 (GLP-2) is dispensable for the regulation of glucose homeostasis under normal conditions, while it can play a beneficial role in obesity conditions. The purpose of the present study was to investigate whether chronic treatment with G
PMID 26832341