English Journal

The effects of cytotoxic necrotizing factor 1 expression in the uptake of Escherichia coli K1 by macrophages and the onset of meningitis in newborn mice.

Chang AC1, Krishnan S1, Prasadarao NV1,2,3.
Virulence.Virulence.2016 May 24:1-13. [Epub ahead of print]
Macrophages are a permissive niche for E. coli K1 multiplication for which the interaction of the bacterial outer membrane protein A and its cognate receptor CD64 are critical. Using in vitro immunofluorescence and live microscopy with ex vivo macrophage cultures from RFP-Lifeact mice, we show that
PMID 27221788

Rosuvastatin enhances anti-inflammatory and inhibits pro-inflammatory functions in cultured microglial cells.

Kata D1, Földesi I2, Feher LZ3, Hackler L Jr3, Puskas LG3, Gulya K4.
Neuroscience.Neuroscience.2016 Feb 9;314:47-63. doi: 10.1016/j.neuroscience.2015.11.053. Epub 2015 Nov 26.
Microglial activation results in profound morphological, functional and gene expression changes that affect the pro- and anti-inflammatory mechanisms of these cells. Although statins have beneficial effects on inflammation, they have not been thoroughly investigated for their ability to affect micro
PMID 26633263

Alternative splicing in the variable domain of CaMKIIβ affects the level of F-actin association in developing neurons.

Zheng J1, Redmond L2, Xu C3, Kuang J4, Liao W5.
International journal of clinical and experimental pathology.Int J Clin Exp Pathol.2014 May 15;7(6):2963-75. eCollection 2014.
The Ca(2+)/calmodulin (CaM)-dependent protein kinase II (CaMKII) β has an essential function in dendritic spines via binding to and reorganization of the actin cytoskeleton during plasticity events not shared by CaMKIIα isoform. CaMKIIβ and CaMKIIα isoforms have remarkable structural differences
PMID 25031715