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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/19 15:33:03」(JST)
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Micronomicin
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Systematic (IUPAC) name |
(1R,2S,3S,4R,6S)-4,6-diamino-3-{[3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl]oxy}-2-hydroxycyclohexyl 2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-α-D-erythro-hexopyranoside
|
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Routes of
administration |
Eye drops, IV |
Legal status |
|
Identifiers |
CAS Number |
52093-21-7 |
ATC code |
S01AA22 (WHO) |
PubChem |
CID 107677 |
ChemSpider |
2301017 |
UNII |
S9AZ0R40QV Y |
KEGG |
D08219 Y |
Synonyms |
(2R,3R,4R,5R)-2-[(1S,2S,4S,6R)-4,6-diamino-3-[(2R,3R,6S)-3-amino-6-(methylaminomethyl)oxan-2-yl]oxy-2-hydroxycyclohexyl]oxy-5-methyl-4-methylaminooxane-3,5-diol |
Chemical data |
Formula |
C20H41N5O7 |
Molar mass |
463.56 g/mol |
SMILES
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C[C@@]1(CO[C@@H]([C@@H]([C@H]1NC)O)O[C@H]2[C@@H](C[C@@H](C([C@@H]2O)O[C@@H]3[C@@H](CC[C@H](O3)CNC)N)N)N)O
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InChI
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InChI=1S/C20H41N5O7/c1-20(28)8-29-19(14(27)17(20)25-3)32-16-12(23)6-11(22)15(13(16)26)31-18-10(21)5-4-9(30-18)7-24-2/h9-19,24-28H,4-8,21-23H2,1-3H3/t9-,10+,11-,12+,13-,14+,15+,16-,17+,18+,19+,20-/m0/s1
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Key:DNYGXMICFMACRA-XHEDQWPISA-N
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(verify) |
Micronomicin (INN) is an aminoglycoside antibiotic for use on the eye.[1][2]
References
- ^ Odakura, Y.; Kase, H.; Nakayama, K. (1983). "Sagamicin and the related aminoglycosides: Fermentation and biosynthesis. III. Isolation and characterization of Micromonospora sagamiensis mutants blocked in gentamicin C1 pathway". The Journal of antibiotics 36 (2): 125–130. doi:10.7164/antibiotics.36.125. PMID 6833127.
- ^ Fukuda, M.; Sasaki, K. (2002). "Antibiotic ophthalmic solutions evaluated by pharmacokinetic parameters of maximum concentration in the aqueous". Nippon Ganka Gakkai zasshi 106 (4): 195–200. PMID 11979978.
Antibacterials: protein synthesis inhibitors (J01A, J01B, J01F, J01G, QJ01XQ)
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30S |
Aminoglycosides
(initiation inhibitors) |
-mycin (Streptomyces) |
- Streptomycin#
- Dihydrostreptomycin
- Neomycin#
- Framycetin
- Paromomycin
- Ribostamycin
- Kanamycin#
- Amikacin
- Arbekacin
- Bekanamycin
- Dibekacin
- Tobramycin
- Spectinomycin#
- Hygromycin B
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|
-micin (Micromonospora) |
- Gentamicin#
- Netilmicin
- Sisomicin
- Isepamicin
|
|
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Tetracycline antibiotics
(tRNA binding) |
Tetracyclines |
- Doxycycline#
- Chlortetracycline
- Clomocycline
- Demeclocycline
- Lymecycline
- Meclocycline
- Metacycline
- Minocycline
- Oxytetracycline
- Penimepicycline
- Rolitetracycline
- Tetracycline
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Glycylcyclines |
|
|
|
|
50S |
Oxazolidinone
(initiation inhibitors) |
- Eperezolid
- Linezolid
- Posizolid
- Radezolid
- Ranbezolid
- Sutezolid
- Tedizolid
|
|
Peptidyl transferase |
Amphenicols |
- Chloramphenicol#
- Azidamfenicol
- Thiamphenicol
- Florfenicol
|
|
Pleuromutilins |
- Retapamulin
- Tiamulin
- Valnemulin
|
|
|
MLS (transpeptidation/translocation) |
Macrolides |
- Azithromycin#
- Clarithromycin
- Dirithromycin
- Erythromycin#
- Flurithromycin
- Josamycin
- Midecamycin
- Miocamycin
- Oleandomycin
- Rokitamycin
- Roxithromycin
- Spiramycin
- Troleandomycin
- Tylosin
- Ketolides
- Telithromycin
- Cethromycin
- Solithromycin†
|
|
Lincosamides |
- Clindamycin#
- Lincomycin
- Pirlimycin
|
|
Streptogramins |
- Pristinamycin
- Quinupristin/dalfopristin
- Virginiamycin
|
|
|
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EF-G |
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
English Journal
- Analysis of micronomicin by liquid chromatography with pulsed electrochemical detection.
- Yuan Y1, Chopra S, Deng X, Zhang M, Fan X, Hu C, Jin S, Van Schepdael A, Adams E.
- Journal of chromatography. A.J Chromatogr A.2013 Jun 21;1295:90-8. doi: 10.1016/j.chroma.2013.04.059. Epub 2013 Apr 27.
- This paper describes the separation of the main component micronomicin from its related substances using a new established liquid chromatographic method with pulsed electrochemical detection (LC-PED). The mobile phase consists of 1 volume of acetonitrile and 99 volumes of an aqueous solution contain
- PMID 23683397
- Femtosecond laser-based mutagenesis strategy for micronomicin production enhancement of Micromonospora sagamiensis ATCC 21826.
- Liu P1, Wen J, Chen Y, Jia X.
- World journal of microbiology & biotechnology.World J Microbiol Biotechnol.2013 Jun;29(6):1121-7. doi: 10.1007/s11274-013-1261-0. Epub 2013 Jan 25.
- In this work, a mutant MX3004 with improved micronomicin (MCR) production was derived from Micromonospora sagamiensis ATCC21826, which was treated with femtosecond laser under the optimized irradiation conditions of 75 mW and 180 s, with a maximum of positive mutation rate of 17.8 % and the mortalit
- PMID 23355136
- Impurity profiling of micronomicin sulfate injection by liquid chromatography-ion trap mass spectrometry.
- Yuan YZ1, Zhao X, Zhang M, Fan XL, Hu CQ, Jin SH, Van Schepdael A, Hoogmartens J, Adams E.
- Journal of pharmaceutical and biomedical analysis.J Pharm Biomed Anal.2013 Mar 5;75:94-104. doi: 10.1016/j.jpba.2012.11.029. Epub 2012 Nov 27.
- The characterization of impurities present in micronomicin sulfate injection by liquid chromatography (LC) coupled with mass spectrometry (MS) is described. A reversed phase (RP)-LC method using a C₁₈ column resistant to an alkaline (pH 11) aqueous mobile phase was developed and coupled to MS wi
- PMID 23261805
Japanese Journal
- Acetylation of Aminoglycoside Antibiotics with 6'-Methylamino Group, Istamycin B and Micronomicin, by a Novel Aminoglycoside 6'-Acetyltransferase of Actinomycete Origin
- Acetylation of Aminoglycoside Antibiotics with 6'-Methylamino Group, Istamycin B and Micronomicin, by a Novel Aminoglycoside 6'-Acetyltransferase of Actinomycete Origin.
- Double Stage Activity in Aminoglycoside Antibiotics.
Related Links
- Visit ChemicalBook To find more Micronomicin(52093-21-7) information like chemical properties,Structure,melting point,boiling point,density,molecular formula,molecular weight, physical properties,toxicity information,customs codes.
- Structure, properties, spectra, suppliers and links for: Micronomicin, 52093-21-7, 66803-19-8. ... Predicted data is generated using the US Environmental Protection Agency’s EPISuite Log Octanol-Water Partition Coef (SRC ...
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