小赤血球症、小球症

WordNet

a blood disorder characterized by the presence of microcytes (abnormally small red blood cells) in the blood; often associated with anemia
make by small short touches that together produce an even or softly graded shadow, as in paint or ink
produce a mottled effect; "The sunlight stippled the trees" (同)speckle
apply (paint) in small dots or strokes
engrave by means of dots and flicks

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/03/18 11:46:33」(JST)

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Microcytosis is a condition in which red blood cells are unusually small as measured by their mean corpuscular volume.^[1]

It is also known as "microcythemia".^[2]

When associated with anemia, it is known as microcytic anemia.

Microcytic anemia is not caused by reduced DNA synthesis (source).

Thalassemia can cause microcytosis. Depending upon how the terms are being defined, thalassemia can be considered a cause of microcytic anemia, or it can be considered a cause of microcytosis but not a cause of microcytic anemia.

There are many causes of microcytosis, which is essentially only a descriptor. Cells can be small because of mutations in the formation of blood cells (hereditary microcytosis) or because they are not filled with enough hemoglobin, as in iron-deficiency-associated microcytosis. Red blood cells can be characterised by their hemoglobin content as well as by their size. The hemoglobin content is referred to as the cell's color. Therefore, there are both "normochromic microcytotic red cells" and "hypochromic, microcytotic red cells". The normochromic cells have a normal concentration of hemoglobin, and are therefore 'red enough' while the hypochromic cells do not; thus the value of the Mean corpuscular hemoglobin concentration.

References[edit]

^ Mach-Pascual S, Darbellay R, Pilotto PA, Beris P (July 1996). "Investigation of microcytosis: a comprehensive approach". Eur. J. Haematol. 57 (1): 54–61. doi:10.1111/j.1600-0609.1996.tb00490.x. PMID 8698132.
^ "microcythemia" at Dorland's Medical Dictionary

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1. 貧血を有する成人患者に対するアプローチ approach to the adult patient with anemia
2. 平均赤血球容積 mean corpuscular volume
3. 成人における鉄欠乏性貧血の原因および診断 causes and diagnosis of iron deficiency anemia in the adult
4. サラセミアの臨床症状および診断 clinical manifestations and diagnosis of the thalassemias
5. 貧血を有する小児に対するアプローチ approach to the child with anemia

English Journal

Normal Hemoglobin at the Age of 1 Year Does not Protect Infants From Developing Iron Deficiency Anemia in the Second Year of Life.

Moser AM, Urkin J, Shalev H.Source*Department of Pediatric Hematology/Oncology, Soroka Medical Center, Ben-Gurion University of the Negev †Clalit Health Services, Southern region and Ben-Gurion University of the Negev, Be'er Sheva, Israel.
Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology.J Pediatr Hematol Oncol.2011 Aug;33(6):467-9.
BACKGROUND: Iron deficiency anemia (IDA) is the most common hematologic disorder worldwide. Measures to prevent IDA in infants have been successful with questionable sustainability.AIM: To evaluate the incidence of developing IDA in the second year of life, in infants who were nonanemic at the age o
PMID 21792044

mTOR inhibition and erythropoiesis: microcytosis or anemia?

Diekmann F, Rovira J, Diaz-Ricart M, Arellano EM, Vodenik B, Jou JM, Vives-Corrons JL, Escolar G, Campistol JM.Source1Department of Nephrology and Kidney Transplantation, Laboratori Experimental de Nefrologia i Transplantament (LENIT), Hospital Clinic, Barcelona, Spain.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.Nephrol Dial Transplant.2011 Jul 22. [Epub ahead of print]
BACKGROUND: Anemia and microcytosis are common post kidney transplantation. The aim of this study was to evaluate the potential role of mammalian target of rapamycin (mTOR) inhibition in the development of anemia and microcytosis in healthy animals and in human erythroid cultures in vitro.METHODS: R
PMID 21785038

Japanese Journal

日本人におけるサラセミアの遺伝子異常

服部幸夫
山口医学 50(3), 637-644, 2001-06-30
… Japanese individuals with thalassemia (thal) are mostly heterozygous and asymptomatic except for microcytosis. … The microcytosis which is characteristic of all thal, is well compensated for by an increased number of red blood cells. …
NAID 110002774076

Hb Gunma (β^<Gunma>) with Pulmonary Embolism

IIZUMI Toshio,SURIKI Hidehisa,SATO Fujio,HARANO Teruo
Internal medicine 34(5), 376-379, 1995-05
… A 67-year-old woman with pulmonary embolism was suspected to have β-thalassemia based on microcytosis, hemolysis and a negative red cell stability test. …
NAID 10006803837