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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/08 10:36:59」(JST)

Metixene, also known as methixene, is an anticholinergic used as an antiparkinsonian agent.

Schmutz, J.; 1959, U.S. Patent 2,905,590.

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English Journal

Development and application of a method to investigate drug-metabolizing enzyme inhibitors using sparteine for probe of cytochrome P450 2D6 and tris(2,2'-bipyridine)ruthenium(II)-electrogenerated chemiluminescence detection.

Shibano Y1, Taki S, Miyamoto A, Uchikura K.
Chemical & pharmaceutical bulletin.Chem Pharm Bull (Tokyo).2011;59(2):249-53.
We studied the detection of drug-metabolizing enzyme inhibitiors using column-switching high performance liquid chromatography with tris(2,2'-bipyridine)ruthenium(II) (Ru(bpy)(3)(2+))-electrogenerated chemiluminescence detection. This can be applied to evaluate the genetic diversity concerning the a
PMID 21297307

Inhibition of inositol-1,4,5-trisphosphate-5-phosphatase by chlorpromazine and related compounds.

Fowler CJ1, Brännström G.
Methods and findings in experimental and clinical pharmacology.Methods Find Exp Clin Pharmacol.1992 Oct;14(8):629-36.
The effects of chlorpromazine and related compounds upon soluble and particulate Ins(1,4,5)P3-5-phosphatase were investigated in rat GH3 pituitary and in human IMR-32 neuroblastoma cells. Chlorpromazine inhibited both soluble and particulate activities with an IC50 of 1 mM after a preincubation time
PMID 1337363

Development and Application of a Method to Investigate Drug-Metabolizing Enzyme Inhibitors Using Sparteine for Probe of Cytochrome P450 2D6 and Tris(2,2'-bipyridine)ruthenium(II)-Electrogenerated Chemiluminescence Detection

RAPID ISOLATION OF ELEVEN ATYPICAL PSYCHOPHARMACEUTICALS WITH SEP-PAK C18 CARTRIDGES AND THEIR SENSITIVEANALYSIS BY GAS CHROMATOGRAPHY WITH A FLAME THERMIONIC DETECTOR

Hattori Hideki,Takashima Eiji,Iwata Masaya,Yamada Takamichi,Suzuki Osamu
1990-12-20
… A simple and rapid method for isolation of carbamazepine, piroheptine, perlapine, chlorprothixen, metixene, clothiapine, zotepine, dosulepin, amoxapine, melitracen and mianserin from urine and plasma samples, is presented: Urine and plasma samples containing the drugs were mixed with weakly alkaline buffer solution, and poured into a pretreated Sep-Pak C18 cartridge; …
NAID 120005313991

リンク元	「メチキセン」
拡張検索	「metixene hydrochloride」

Metixene
Systematic (IUPAC) name
	1-methyl-3-(9H-thioxanthen-9-ylmethyl)piperidine
Clinical data
AHFS/Drugs.com	International Drug Names
Identifiers
CAS Registry Number	4969-02-2
ATC code	N04AA03
PubChem	CID: 4167
IUPHAR/BPS	7232
DrugBank	DB00340
ChemSpider	4023
UNII	32VY6L26ZW
KEGG	D01871
ChEMBL	CHEMBL1201342
Chemical data
Formula	C20H23NS
Molecular mass	309.469 g/mol
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