methylnitronitrosoguanidine

メチルニトロニトロソグアニジン

関

MNNG、N-methyl-N'-nitro-N-nitrosoguanidine

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/09/25 13:46:24」(JST)

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Methylnitronitrosoguanidine

Names
IUPAC name 1-methyl-3-nitro-1-nitrosoguanidine
Other names N-Methyl-N-nitroso-N′-nitroguanidine; N-Methlyl-N′-nitro-N-nitrosoguanidine
Identifiers
CAS Registry Number	70-25-7 N
Abbreviations	MNNG
Jmol-3D images	Image
KEGG	C14592 Y
PubChem	9562060
SMILES CN(C(=N[N+](=O)[O-])N)N=O
Properties
Chemical formula	C2H5N5O3
Molar mass	147.09 g/mol
Appearance	Yellow crystals
Melting point	118 °C (244 °F; 391 K) (decomposes)
Solubility in water	reacts violently, slowly hydrolysed
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Y verify (what is: Y/N?)
Infobox references

Methylnitronitrosoguanidine (MNNG or MNG) is a biochemical tool used experimentally as a carcinogen and mutagen. It acts by adding alkyl groups to the O⁶ of guanine and O⁴ of thymine, which can lead to transition mutations between GC and AT. These changes do not cause a heavy distortion in the double helix of DNA and thus are hard to detect by the DNA mismatch repair system.

In organic chemistry, MNNG is used as a source of diazomethane when reacted with aqueous potassium hydroxide.

MNNG is a probable human carcinogen listed as an IARC Group 2A carcinogen.

References

English Journal

• Antigenotoxic activity of lactic acid bacteria, prebiotics, and products of their fermentation against selected mutagens.

• Nowak A1, Śliżewska K2, Otlewska A2.
• Regulatory toxicology and pharmacology : RTP.Regul Toxicol Pharmacol.2015 Sep 25. pii: S0273-2300(15)30070-2. doi: 10.1016/j.yrtph.2015.09.021. [Epub ahead of print]
• Dietary components such as lactic acid bacteria (LAB) and prebiotics can modulate the intestinal microbiota and are thought to be involved in the reduction of colorectal cancer risk. The presented study measured, using the comet assay, the antigenotoxic activity of both probiotic and non-probiotic L
• PMID 26404012

• Repeated dose liver and gastrointestinal tract micronucleus assays using N-methyl-N'-nitro-N-nitrosoguanidine in young adult rats.

• Takayanagi T1, Wako Y2, Kawasako K2, Hori H1, Fujii W1, Ohyama W3.
• Mutation research. Genetic toxicology and environmental mutagenesis.Mutat Res Genet Toxicol Environ Mutagen.2015 Mar;780-781:100-6. doi: 10.1016/j.mrgentox.2014.12.009. Epub 2015 Jan 4.
• N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG) is a direct-acting mutagen that induces tumors in the glandular stomach, but not in the liver or colon, of rats after oral administration. To evaluate the performance of repeated dose liver and gastrointestinal tract micronucleus (MN) assays in young adult
• PMID 25892628

• Chemoprotection of MNNG-initiated gastric cancer in rats using Iranian propolis.

• Alizadeh AM1, Afrouzan H2, Dinparast-Djadid N3, Sawaya AC4, Azizian S5, Hemmati HR5, Mohagheghi MA5, Erfani S5.
• Archives of Iranian medicine.Arch Iran Med.2015 Jan;18(1):18-23. doi: 0151801/AIM.006.
• BACKGROUND: Iranian propolis is a natural product of honeybees that has significant and varied anti-cancer benefits. The present study was designed to investigate the protective effects of Iranian propolis on gastric tissue carcinogenesis in an animal model. METHODS: Propolis samples were collected
• PMID 25556381

Japanese Journal

• Duodenogastric Reflux Increases the Penetration of N-^3H-Methyl-N-nitro-N-nitrosoguanidine into the Antral Mucosa of Rats: A Possible Role for Mucosal Erosions and Increased Cell Proliferation in Gastric Carcinogenesis

• OVREBO Kiell K.,SVANES Knut,AASE Steinar,GRONG Ketil,SORBYE Halfdan
• Japanese journal of cancer research : gann 93(5), 484-494, 2002-05-31
• NAID 50001145909

Related Links

• Methylnitronitrosoguanidine - RightDiagnosis.com

Methylnitronitrosoguanidine information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Methylnitronitrosoguanidine Description of Methylnitronitrosoguanidine ...

• URMC Research Network - Methylnitronitrosoguanidine

"Methylnitronitrosoguanidine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). ... This graph shows the total number of publications written about ...

Related Pictures

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★リンクテーブル★

リンク元	「N-methyl-N'-nitro-N-nitrosoguanidine」「メチルニトロニトロソグアニジン」「MNNG」

「N-methyl-N'-nitro-N-nitrosoguanidine」

　　[★]

N-メチル-N'-ニトロ-N-ニトロソグアニジン、メチルニトロニトロソグアニジン

関

methylnitronitrosoguanidine、MNNG

「メチルニトロニトロソグアニジン」

　　[★]

英

N-methyl-N'-nitro-N-nitrosoguanidine、methylnitronitrosoguanidine、MNNG

関

N-メチル-N'-ニトロ-N-ニトロソグアニジン

「MNNG」

　　[★]

• メチルニトロニトロソグアニジン

関

methylnitronitrosoguanidine、N-methyl-N'-nitro-N-nitrosoguanidine